Different risk factor profiles between silent brain infarction and symptomatic lacunar infarction

European Neurology

Volumn 65, Issue 5, 2011, Pages 250-256

  Kim, Mi Hwa ^a   Moon, Ju Sun ^a   Park, So Young ^a   An, Se A ^a   Kim, Ok Joon ^a   Kim, Nam Keun ^a   Oh, Seung Hun ^a  

^a CHA University   (South Korea)

Author keywords

Homocysteine; Lacunar infarction; Pathogenesis; Risk factor; Silent brain infarction

Indexed keywords

CREATININE; GLUCOSE; HOMOCYSTEINE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; BODY MASS; BRAIN INFARCTION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIASTOLIC BLOOD PRESSURE; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HEART ATRIUM FIBRILLATION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; ISCHEMIC HEART DISEASE; LACUNAR INFARCTION; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; NUCLEAR MAGNETIC RESONANCE IMAGING; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; SILENT BRAIN INFARCTION; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; AGED, 80 AND OVER; BRAIN; BRAIN INFARCTION; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PREVALENCE; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS;

EID: 79953256297     PISSN: 00143022     EISSN: 14219913     Source Type: Journal    
DOI: 10.1159/000324335     Document Type: Article

References (33)

1. Vermeer SE, Longstreth WT Jr, Koudstaal PJ: Silent brain infarcts: A systematic review. Lancet Neurol 2007; 6: 611-619. (Pubitemid 46921055)
2. Bernick C, Kuller L, Dulberg C, Longstreth WT Jr, Manolio T, Beauchamp N, Price T: Silent MRI infarcts and the risk of future stroke: The Cardiovascular Health Study. Neurology 2001; 57: 1222-1229. (Pubitemid 32947380)
3. Vermeer SE, Hollander M, van Dijk EJ, Hofman A, Koudstaal PJ, Breteler MM: Silent brain infarcts and white matter lesions increase stroke risk in the general population: The Rotterdam Scan Study. Stroke 2003; 34: 1126-1129. (Pubitemid 36547501)
4. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MM: Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med 2003; 348: 1215-1222. (Pubitemid 36359297)
5. Wardlaw JM: What is a lacune? Stroke 2008; 39: 2921-2922.
6. Song YM: Distinct location of subcortical silent infarcts compared with symptomatic lacunar infarcts. J Neurol Sci 2009; 287: 197-199.
7. Fisher CM: The arterial lesions underlying lacunes. Acta Neuropathol 1968; 12: 1-15.
8. Boiten J, Lodder J, Kessels F: Two clinically distinct lacunar infarct entities? A hypothesis. Stroke 1993; 24: 652-656. (Pubitemid 23134281)
9. Prabhakaran S, Wright CB, Yoshita M, Delapaz R, Brown T, DeCarli C, Sacco RL: Prevalence and determinants of subclinical brain infarction: The Northern Manhattan Study. Neurology 2008; 70: 425-430.
10. Gouw AA, van der Flier WM, Fazekas F, van Straaten EC, Pantoni L, Poggesi A, Inzitari D, Erkinjuntti T, Wahlund LO, Waldemar G, Schmidt R, Scheltens P, Barkhof F, LADIS Study Group: Progression of white matter hyperintensities and incidence of new lacunes over a 3-year period: The Leukoarai - osis and Disability Study. Stroke 2008; 39: 1414-1420.
11. Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O'Donnell CJ, Yoshita M, D'Agostino RB Sr, DeCarli C, Wolf PA: Prevalence and correlates of silent cerebral infarcts in the Framingham Offspring Study. Stroke 2008; 39: 2929-2935.
12. Khan U, Porteous L, Hassan A, Markus HS: Risk factor profile of cerebral small vessel disease and its subtypes. J Neurol Neurosurg Psychiatry 2007; 78: 702-706. (Pubitemid 46998839)
13. Vermeer SE, Koudstaal PJ, Oudkerk M, Hofman A, Breteler MM: Prevalence and risk factors of silent brain infarcts in the population- based Rotterdam Scan Study. Stroke 2002; 33: 21-25. (Pubitemid 34052178)
14. Notsu Y, Nabika T, Park HY, Masuda J, Kobayashi S: Evaluation of genetic risk factors for silent brain infarction. Stroke 1999; 30: 1881-1886. (Pubitemid 29411831)
15. Fazekas F, Chawluk JB, Alavi A, Hurtig HI, Zimmerman RA: MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging. AJR 1987; 149: 351-356. (Pubitemid 17104996)
16. Longstreth WT Jr, Dulberg C, Manolio TA, Lewis MR, Beauchamp NJ Jr, O'Leary D, Carr J, Furberg CD: Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: The Cardiovascular Health Study. Stroke 2002; 33: 2376-2382.
17. Longstreth WT Jr, Bernick C, Manolio TA, Bryan N, Jungreis CA, Price TR: Lacunar infarcts defined by magnetic resonance imaging of 3,660 elderly people: The Cardiovascular Health Study. Arch Neurol 1998; 55: 1217-1225.
18. Lee SC, Park SJ, Ki HK, Gwon HC, Chung CS, Byun HS, Shin KJ, Shin MH, Lee WR: Prevalence and risk factors of silent cerebral infarction in apparently normal adults. Hypertension 2000; 36: 73-77. (Pubitemid 30602155)
19. Jackson C, Sudlow C: Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts. Stroke 2005; 36: 891-901.
20. Howard G, Wagenknecht LE, Cai J, Cooper L, Kraut MA, Toole JF: Cigarette smoking and other risk factors for silent cerebral infarction in the general population. Stroke 1998; 29: 913-917. (Pubitemid 28228148)
21. Imamura T, Doi Y, Arima H, Yonemoto K, Hata J, Kubo M, Tanizaki Y, Ibayashi S, Iida M, Kiyohara Y: LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: The Hisayama Study. Stroke 2009; 40: 382-388.
22. Jackson CA, Hutchison A, Dennis MS, Wardlaw JM, Lindgren A, Norrving B, Anderson CS, Hankey GJ, Jamrozik K, Appelros P, Sudlow CL: Differing risk factor profiles of ischemic stroke subtypes: Evidence for a distinct lacunar arteriopathy? Stroke 2010; 41: 624-629.
23. Bejot Y, Osseby GV, Gremeaux V, Durier J, Rouaud O, Moreau T, Giroud M: Changes in risk factors and preventive treatments by stroke subtypes over 20 years: A populationbased study. J Neurol Sci 2009; 287: 84-88.
24. Hoshide S, Kario K, Mitsuhashi T, Sato Y, Umeda Y, Katsuki T, Shimada K: Different patterns of silent cerebral infarct in patients with coronary artery disease or hypertension. Am J Hypertens 2001; 14: 509-515. (Pubitemid 32506723)
25. Choi BO, Kim NK, Kim SH, Kang MS, Lee S, Ahn JY, Kim OJ, Kim S, Oh D: Homozygous C677T mutation in the MTHFR gene as an independent risk factor for multiple smallartery occlusions. Thromb Res 2003; 111: 39-44. (Pubitemid 37485924)
26. Sasaki T, Watanabe M, Nagai Y, Hoshi T, Takasawa M, Nukata M, Taguchi A, Kitagawa K, Kinoshita N, Matsumoto M: Association of plasma homocysteine concentration with atherosclerotic carotid plaques and lacunar infarction. Stroke 2002; 33: 1493-1496. (Pubitemid 34619945)
27. Vermeer SE, van Dijk EJ, Koudstaal PJ, Oudkerk M, Hofman A, Clarke R, Breteler MM: Homocysteine, silent brain infarcts, and white matter lesions: The Rotterdam Scan Study. Ann Neurol 2002; 51: 285-289. (Pubitemid 34206283)
28. Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, Yoshita M, Rosenberg IH, D'Agostino RB, DeCarli C: Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol 2008; 65: 642-649. (Pubitemid 351679660)
29. Howard VJ, Sides EG, Newman GC, Cohen SN, Howard G, Malinow MR, Toole JF: Changes in plasma homocyst(e)ine in the acute phase after stroke. Stroke 2002; 33: 473-478. (Pubitemid 34123390)
30. Lentz SR: Mechanisms of homocysteineinduced atherothrombosis. J Thromb Haemost 2005; 3: 1646-1654.
31. Hassan A, Hunt BJ, O'Sullivan M, Parmar K, Bamford JM, Briley D, Brown MM, Thomas DJ, Markus HS: Markers of endothelial dysfunction in lacunar infarction and ischaemic leukoaraiosis. Brain 2003; 126: 424-432. (Pubitemid 36172746)
32. Liao D, Cooper L, Cai J, Toole J, Bryan N, Burke G, Shahar E, Nieto J, Mosley T, Heiss G: The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: The ARIC Study. Neuroepidemiology 1997; 16: 149-162. (Pubitemid 27215864)
33. Longstreth WT Jr, Manolio TA, Arnold A, Burke GL, Bryan N, Jungreis CA, Enright PL, O'Leary D, Fried L: Clinical correlates of white matter findings on cranial magnetic resonance imaging of 3,301 elderly people: The Cardiovascular Health Study. Stroke 1996; 27: 1274-1282. (Pubitemid 26286152)