RelA-associated inhibitor blocks transcription of human immunodeficiency virus type 1 by inhibiting NF-κB and Sp1 actions

Journal of Virology

Volumn 76, Issue 16, 2002, Pages 8019-8030

  Takada, Norio ^a   Sanda, Takaomi ^a   Okamoto, Hiroshi ^a   Yang, Jian Ping ^a   Asamitsu, Kaori ^a   Sarol, Lilen ^a   Kimura, Genjiro ^a   Uranishi, Hiroaki ^a   Tetsuka, Toshifumi ^a   Okamoto, Takashi ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; RECOMBINANT PROTEIN; RELA ASSOCIATED INHIBITOR; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

ARTICLE; CELL LYSATE; CONTROLLED STUDY; DNA BINDING; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LONG TERMINAL REPEAT; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; TRANSCRIPTION REGULATION; VIRUS INHIBITION; VIRUS REPLICATION;

BASE SEQUENCE; CARRIER PROTEINS; CELL LINE; CELL NUCLEUS; GENE EXPRESSION; GENES, VIRAL; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, BIOLOGICAL; NF-KAPPA B; PLASMIDS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRUS REPLICATION;

EID: 0036318978     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.16.8019-8030.2002     Document Type: Article

References (40)

1. NF-κB as a frequent target for immunosuppressive and anti-inflammatory molecules
2. The NF-κB and IκB proteins: New discoveries and insights
3. Induction of SP1-p53 DNA-binding heterocomplexes during granulocyte/macrophage colony-stimulating factor dependent proliferation in human erythroleukemia cell line TF-1
4. The relinoblastoma gene product RB stimulates Sp1-mediated transcription by liberating Sp1 from a negative regulator
5. Association of p107 with Sp1: Genetically separable regions of p 107 are involved in regulation of E2F and Sp1-dependent transcription
6. The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-βB p50 homodimers
7. CREB-binding protein/p300 are transcriptional coactivators of p65
8. Structure of NF-κB p50 homodimer bound to a κ B site
9. Oxidoreductive regulation of nuclear factor κB. Involvement of a cellular reducing catalyst thioredoxin
10. Hostile takeovers: Viral approprication of the NF-κB pathway
11. Tat compeles with CIITA for the binding to P-TEFb and blockes the expression of MHC class II genes in HIV infection
12. Tackling Tat
13. Inducible expression of IKBa 1,B, repressor mutants interferes with NF-κB activity and HIV-1 replication in Jurkat T cells
14. Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription
15. Molecular mechanism for cooperation between Sp1 and steroidogenic factor-1 (SF-1) to regulate bovine CYP11A gene expression
16. Stat 1 depends on transcriptional synergy with Sp1
17. IκBα functions through direct contacts with the nuclear localization signals and the DNA binding sequences of NF-κB
18. The von Hippel-Lindau tumor suppressor gene product interacts with Sp1 to repress vascular endothelial growth factor promoter activity
19. Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II
20. Augmentation of human immunodeficiency virus type 1 gene expression by tumor necrosis factor α
21. Transcriptional activation from the long terminal repeal of human immunodeficiency virus in vitro
22. Regulation of NF-κB and disease control: Identification of a novel serine kinase and thioredoxin as effectors for signal transduction pathway for NF-κB activation
23. SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein
24. NF-κB-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro
25. An interaction between the DNA-binding domains of RelA(p65) and Sp1 mediates human immunodeficiency virus gene activation
26. Potent and stable attenuation of live-HIV-1 by gain of a proteolysis-resistant inhibitor of NF-κB (IκB-αS32/36A) and the implications for vaccine development
27. Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride
28. NF-κB: Mediator of pathogen and stress responses
29. Characterization of long terminal repeat sequences of HTLV-III
30. Autoregulation of the NF-κB transactivator RelA (p65) by multiple cytoplasmic inhibitors containing ankyrin motifs
31. Inhibition of nuclear factor-κB-mediated transcription by association with the amino-terminal enhancer of split, a groucho-related protein lacking WD40 repeats
32. Anti-rheumatic compound aurothioglucose inhibits tumor necrosis factor-α-induced HIV-1 replication in latently infected OM10.1 and Ach2 cells
33. A lipopolysaccharide-specific enhancer complex involving Ets, Elk-1, Sp1, and CREB binding protein and p300 is recruited to the tumor necrosis factor α promoter in vivo
34. The promyelocytic leukemia protein interacts with Sp1 and inhibits its transactivation of the epidermal growth factor receptor promoter
35. Sp1 increases expression of cyclooxygenase-2 in hypoxic vascular endothelium
36. Inhibition of the DNA-binding activity of NF-κB by gold compounds in vitro
37. NF-κB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2
38. Identification of a Novel inhibitor of nuclear factor-κB, RelA-associated inhibitor
39. Lipopolysaccharide induction of the tumor necrosis factor-α promoter in human monocyte cells