Synthesis and in vitro antimicrobial evaluation of condensed heterocyclic 6-substituted 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole and 1,3,4-oxadiazole derivatives of isoniazid

Acta Poloniae Pharmaceutica - Drug Research

Volumn 68, Issue 2, 2011, Pages 205-211

  Gilani, Sadaf Jamal ^a,b   Khan, Suroor Ahmad ^a   Alam, Ozair ^a   Siddiqui, Nadeem ^a  

^a HAMDARD UNIVERSITY   (India)

^b KRISHNA INSTITUTE OF ENGINEERING AND TECHNOLOGY   (India)

Author keywords

1,3,4 Oxadiazole; Antimicrobial activity; Isoniazid; Triazolo thiadiazole

Indexed keywords

2 (2 CHLOROPHENYL 5 (PYRIDIN 4 YL) 1,3,4 OXADIAZOLE; 2 (2,4 DICHLOROPHENYL 5 (PYRIDIN 4 YL) 1,3,4 OXADIAZOLE; 2 (4 NITROPHENYL 5 (PYRIDIN 4 YL) 1,3,4 OXADIAZOLE; 2 (5 (PYRIDIN 4 YL) 1,3,4 OXADIAZOLE 2 YL)PHENYL ACETATE; 2 (PYRIDIN 4 YL) 5 O TOLYL 1,3,4 OXADIAZOLE; 2 [3 (PYRIDIN 4 YL) 1,2,4 TRIAZOLO(3,4 B) 1,3,4 THIADIAZOL 6 YL]PHENYL ACETATE; 2 PHENOXY 5 (PYRIDIN 4 YL) 1,3,4 OXADIAZOLE; 2 PHENYL 5 (PYRIDIN 4 YL) 1,3,4 OXADIAZOLE; 3 (PYRIDIN 4 YL) 6 O TOLYL 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 6 (2 CHLOROPHENYL) 3 (PYRIDIN 4 YL) 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 6 (2,4 DICHLOROPHENYL) 3 (PYRIDIN 4 YL) 1,2,4 TRIADIAZOLE; 6 (4 NITROPHENYL) 3 (PYRIDIN 4 YL) 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 6 PHENOXY 3 (PYRIDIN 4 YL) 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; 6 PHENYL 3 (PYRIDIN 4 YL) 1,2,4 TRIAZOLO[3,4 B] 1,3,4 THIADIAZOLE; ANTIINFECTIVE AGENT; ISONIAZID DERIVATIVE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM; DRUG STRUCTURE; DRUG SYNTHESIS; FUNGAL STRAIN; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; SUBSTITUTION REACTION;

ANTI-BACTERIAL AGENTS; BACTERIA; ISONIAZID; MAGNETIC RESONANCE SPECTROSCOPY; MICROBIAL SENSITIVITY TESTS; MITOSPORIC FUNGI; MOLECULAR STRUCTURE; OXADIAZOLES; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 79953250660     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. rd edn., p. 559-582, Oxford University Press, New York 2005.
2. Zitouni T.G., Kaplancikli A.Z., Yildiz T.M., Chevallet P., Kaya D.: Eur. J. Med. Chem. 40, 607 (2005).
3. Swamy N.S., Basappa, Priya S.B., Prabhuswamy B., Doreswamy B.H., Prasad S.J., Rangappa S.: Eur. J. Med. Chem. 41, 531 (2006).
4. Karegoudar P., Prasad J. D., Ashok M., Mahalinga M., Poojary B., Holla S.B.: Eur. J. Med. Chem. 43, 808 (2008).
5. Mathew V., Keshavayya J., Vaidya P.V.: Eur. J. Med. Chem. 41, 1048 (2006).
6. Ibrahim D.A. Eur. J. Med. Chem. 44, 2776 (2009).
7. Amir M., Kumar H., Javed A. S.: Bioorg. Med. Chem. Lett. 17, 4504 (2007).
8. Mathew V., Keshavayya J.,Vaidya P.V., Giles D.: Eur. J. Med. Chem. 42, 823 (2007).
9. Mathew V., Keshavayya J., Vaidya P.V.: Eur. J. Med. Chem. 41, 1048 (2006).
10. Padmavathi V., Mohan N.V.A., Thriveni P., Shazia A.: Eur. J. Med. Chem. 44, 2313 (2009).
11. Kadi A.A., El-Brollosy R.N., Al-Deeb A.O., Habib E.E., Ibrahim M.T., El-Emam A.A.: Eur. J. Med. Chem. 42, 235 (2007).
12. Kumar H., Javed S.A., Khan S.A., Amir M.: Eur. J. Med. Chem. 43, 2688 (2008).
13. Onkol T., Dogruer S.D., Leylauzun, Adak S., Ozkan S., Sahin F.M.: J. Enz. Inh. Med. Chem. 23, 277 (2008).
14. Barry A.L.: Procedure for testing antimicrobial agents in agar media. in Antibiotics in Laboratory Medicine, Corian V.L. Ed., p. 1, Williams and Wilkins, Baltimore 1991.
15. Verma S.R., Khan K.Z., A.P. Singh P.A.: Antifungal Agents: Past, Present and Future Prospects, p. 55, National Academy of Chemistry and Biology, Lucknow, India 1998.