메뉴 건너뛰기




Volumn 18, Issue 4, 2011, Pages 281-293

Formulation and development of release modulated colon targeted system of meloxicam for potential application in the prophylaxis of colorectal cancer

Author keywords

buffering agent; colon specific delivery; COX 2; polyethylene oxide; roentgenography

Indexed keywords

ACRYLIC ACID METHYL ESTER; ETHYL CELLULOSE; MACROGOL; MELOXICAM; METHACRYLIC ACID; METHACRYLIC ACID METHYL ESTER;

EID: 79953250247     PISSN: 10717544     EISSN: 15210464     Source Type: Journal    
DOI: 10.3109/10717544.2010.538447     Document Type: Article
Times cited : (45)

References (49)
  • 2
    • 13744256029 scopus 로고    scopus 로고
    • Chemoprevention of colorectal cancer: Ready for routine use
    • Ahmedin, J., Rebecca, S., Elizabeth, W., Yongping, H., Jiaquan, X., Michael, J.T. (2009). Cancer Statistics. CA Cancer J Clin. 59:225-49. Arber, N., Levin, B. (2005). Chemoprevention of colorectal cancer: Ready for routine use? Recent Results Cancer Res. 166:213-30.
    • (2005) Recent Results Cancer Res , vol.166 , pp. 213-230
    • Arber, N.1    Levin, B.2
  • 3
    • 56349110045 scopus 로고    scopus 로고
    • Design and evaluation of matrices of Eudragit with polycarbophil and carbopol for colon specific delivery
    • Asghar, L.F., Chandran, S. (2008). Design and evaluation of matrices of Eudragit with polycarbophil and carbopol for colon specific delivery. J Drug Target. 16:741-57.
    • (2008) J Drug Target , vol.16 , pp. 741-757
    • Asghar, L.F.1    Chandran, S.2
  • 5
    • 69549110194 scopus 로고    scopus 로고
    • Antitumor effects of acyclooxygenase-2 inhibitor, meloxicam, alone and in combination with radiation and/or 5-fluorouracil in cultured tumor cells
    • Ayakawa, S., Shibamoto, Y., Sugie, C., Ito, M., Ogino, H., Tomita, N., Kumagai, M., Murakami, H., Sawa, H. (2009). Antitumor effects of acyclooxygenase-2 inhibitor, meloxicam, alone and in combination with radiation and/or 5-fluorouracil in cultured tumor cells. Mol Med Repor. 2:621-5.
    • (2009) Mol Med Repor , vol.2 , pp. 621-625
    • Ayakawa, S.1    Shibamoto, Y.2    Sugie, C.3    Ito, M.4    Ogino, H.5    Tomita, N.6    Kumagai, M.7    Murakami, H.8    Sawa, H.9
  • 8
    • 0030299879 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drugs, eicosanoids, and colorectal cancer prevention
    • DOI 10.1016/S0889-8553(05)70274-0
    • DuBois, R.N., Giardiello, F.M., Smalley, W.E. (1996). Nonsteroidal anti-inflammatory drugs, eicosanoids, and colorectal cancer prevention. Gastroenterol Clin North Am. 25:773-91. (Pubitemid 27022915)
    • (1996) Gastroenterology Clinics of North America , vol.25 , Issue.4 , pp. 773-791
    • DuBois, R.N.1    Giardiello, F.M.2    Smalley, W.E.3
  • 9
    • 0034690954 scopus 로고    scopus 로고
    • Preparation of enteric coated timed release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting
    • Fukui, E., Miyamura, N., Uemura, K., Kobayashi, M. (2000). Preparation of enteric coated timed release press-coated tablets and evaluation of their function by in vitro and in vivo tests for colon targeting. Int J Pharm. 204:7-15.
    • (2000) Int J Pharm , vol.204 , pp. 7-15
    • Fukui, E.1    Miyamura, N.2    Uemura, K.3    Kobayashi, M.4
  • 11
    • 33748296312 scopus 로고    scopus 로고
    • ® FS 30 D-coated pellets
    • DOI 10.1016/j.ijpharm.2006.05.035, PII S0378517306004194
    • Gao, C., Huang, J., Jiao, Y., Shan, L., Liu, Y., Li, Y., Mei, X. (2006). In vitro release and in vivo absorption in beagle dogs of meloxicam from Eudragit® FS 30 D coated pellets. Int J Pharm. 322:104-12. (Pubitemid 44331530)
    • (2006) International Journal of Pharmaceutics , vol.322 , Issue.1-2 , pp. 104-112
    • Gao, C.1    Huang, J.2    Jiao, Y.3    Shan, L.4    Liu, Y.5    Li, Y.6    Mei, X.7
  • 12
    • 23144462417 scopus 로고    scopus 로고
    • Tablet formulation containing meloxicam and β-cyclodextrin: Mechanical characterization and bioavailability evaluation
    • Available online at, accessed 7 June 2008
    • Ghorab, M.M., Abdel-Salam, H.M., El-Sayad, M.A., Mekhel, M.M. (2004). Tablet formulation containing meloxicam and β-cyclodextrin: Mechanical characterization and bioavailability evaluation. AAPS PharmSciTech. Available online at: http://www.aapspharmscitech.org/view.asp?art=pt050459, accessed 7 June 2008.
    • (2004) AAPS PharmSciTech
    • Ghorab, M.M.1    Abdel-Salam, H.M.2    El-Sayad, M.A.3    Mekhel, M.M.4
  • 14
    • 0029147277 scopus 로고
    • The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention
    • Giardiello, F.M., Offerhaus, G.J.A., DuBois, R.N. (1995). The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention. Eur J Cancer. 31:1071-6.
    • (1995) Eur J Cancer , vol.31 , pp. 1071-1076
    • Giardiello, F.M.1    Offerhaus, G.J.A.2    DuBois, R.N.3
  • 15
    • 84890621355 scopus 로고    scopus 로고
    • Bels, V., ed. Feeding in domestic vertebrates: From structure to behavior. Oxfordshire: CABI Publishing
    • Gidenne, T., Lebas, F. (2006). Feeding behavior in rabbits. In: Bels, V., ed. Feeding in domestic vertebrates: From structure to behavior. Oxfordshire: CABI Publishing, 179-94.
    • (2006) Feeding Behavior in Rabbits , pp. 179-194
    • Gidenne, T.1    Lebas, F.2
  • 18
    • 34547561752 scopus 로고    scopus 로고
    • Cancer chemoprevention by cyclooxygenase 2 (cox-2) blockade
    • Harris, R.E., ed. Inflammation in the pathogenesis of chronic diseases: The COX-2 controversy. New York: Springer, accessed 9 February 2009
    • Harris, R.E., Beebe-Donk, J., Alshafie, G.A. (2007). Cancer chemoprevention by cyclooxygenase 2 (COX-2) blockade. In: Harris, R.E., ed. Inflammation in the pathogenesis of chronic diseases: The COX-2 controversy. New York: Springer Science, 193-212. http://www.pharma-polymers.com, accessed 9 February 2009.
    • (2007) Science , pp. 193-212
    • Harris, R.E.1    Beebe-Donk, J.2    Alshafie, G.A.3
  • 19
    • 20444447440 scopus 로고    scopus 로고
    • In vitro evaluation of coating polymers for enteric coating and human ileal targeting
    • DOI 10.1016/j.ijpharm.2005.03.032, PII S0378517305002206
    • Huyghebaert, N., Vermeire, A., Remon, J.P. (2005). In vitro evaluation of coating polymers for enteric coating and human ileal targeting. Int J Pharm. 298:26-37. (Pubitemid 40828326)
    • (2005) International Journal of Pharmaceutics , vol.298 , Issue.1 , pp. 26-37
    • Huyghebaert, N.1    Vermeire, A.2    Remon, J.P.3
  • 20
    • 0035111370 scopus 로고    scopus 로고
    • Pharmacokinetics of acetaminophen from rapidly disintegrating compressed tablet prepared using microcrystalline cellulose (PH-M-06) and spherical sugar granules
    • DOI 10.1248/cpb.49.230
    • Ishikawa, T., Koizumi, N., Mukai, B., Utoguchi, N., Fujii, M., Matsumoto, M., Endo, H., Shirotake, S., Watanabe, Y. (2001). Pharmacokinetics of acetaminophen from rapidly disintegrating compressed tablet prepared using microcrystalline cellulose (PH-M-06) and spherical sugar granules. Chem Pharm Bull. 49:230-2. (Pubitemid 32174661)
    • (2001) Chemical and Pharmaceutical Bulletin , vol.49 , Issue.2 , pp. 230-232
    • Ishikawa, T.1    Koizumi, N.2    Mukai, B.3    Utoguchi, N.4    Fujii, M.5    Matsumoto, M.6    Endo, H.7    Shirotake, S.8    Watanabe, Y.9
  • 21
    • 0032995635 scopus 로고    scopus 로고
    • A pH-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation of drug release using Eudragit® L100-55 and Eudragit® S100 combinations
    • DOI 10.1016/S0168-3659(98)00151-5, PII S0168365998001515
    • H-dependent colon targeted oral drug delivery system using methacrylic acid copolymers. I. Manipulation of drug release using Eudragit L100-55 and Eudragit S100 combinations. J Control Rel. 58:215-22. (Pubitemid 29112892)
    • (1999) Journal of Controlled Release , vol.58 , Issue.2 , pp. 215-222
    • Khan, M.Z.I.1    Prebeg, Z.2    Kurjakovic, N.3
  • 22
    • 0034005158 scopus 로고    scopus 로고
    • A pH-dependent colon-targeted oral drug delivery system using methacrylic acid copolymers. II. Manipulation of drug release using Eudragit® L100 and Eudragit S100 combinations
    • DOI 10.1081/DDC-100101266
    • H- dependent colon-targeted oral drug delivery system using methacrylic acid copolymers. II. Manipulation of drug release using Eudragit® L100 and Eudragit® S100 combinations. Drug Dev Ind Pharm. 26:549-54. (Pubitemid 30225633)
    • (2000) Drug Development and Industrial Pharmacy , vol.26 , Issue.5 , pp. 549-554
    • Khan, M.Z.I.1    Stedul, H.P.2    Kurjakovic, N.3
  • 23
    • 0037006927 scopus 로고    scopus 로고
    • Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment of amoebiasis
    • DOI 10.1016/S0378-5173(02)00006-6, PII S0378517302000066
    • Krishnaiah, Y.S., Bhaskar Reddy, P.R., Satyanarayana, V., Karthikeyan, R.S. (2002). Studies on the development of oral colon targeted drug delivery systems for metronidazole in the treatment of amoebiasis. Int J Pharm. 236:43-55. (Pubitemid 34219372)
    • (2002) International Journal of Pharmaceutics , vol.236 , Issue.1-2 , pp. 43-55
    • Krishnaiah, Y.S.R.1    Bhaskar Reddy, P.R.2    Satyanarayana, V.3    Karthikeyan, R.S.4
  • 24
    • 34248658271 scopus 로고    scopus 로고
    • Development of pH- and time-dependent oral microparticles to optimize budesonide delivery to ileum and colon
    • DOI 10.1016/j.ijpharm.2007.02.015, PII S0378517307001664
    • Hand time-dependent oral microparticles to optimize budesonide delivery to ileum and colon. Int J Pharm. 338:238-47. (Pubitemid 46777247)
    • (2007) International Journal of Pharmaceutics , vol.338 , Issue.1-2 , pp. 238-247
    • Krishnamachari, Y.1    Madan, P.2    Lin, S.3
  • 26
    • 0033014363 scopus 로고    scopus 로고
    • Regulatory aspects of stability testing in europe
    • Mathews, B.R. (1999). Regulatory aspects of stability testing in Europe. Drug Dev Ind Pharm. 25:831-56.
    • (1999) Drug Dev Ind Pharm , vol.25 , pp. 831-856
    • Mathews, B.R.1
  • 27
    • 49749094364 scopus 로고    scopus 로고
    • H and bacteria as physiological trigger mechanisms for colonic targeting in man
    • H and bacteria as physiological trigger mechanisms for colonic targeting in man. J Control Rel. 130:154-60.
    • (2008) J Control Rel , vol.130 , pp. 154-160
    • McConnell, E.L.1    Short, M.D.2    Basit, A.W.3
  • 28
    • 33644905567 scopus 로고    scopus 로고
    • Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes
    • DOI 10.1093/carcin/bgi240
    • Naruse, T., Nishida, Y., Hosono, K., Ishiguro, N. (2006). Meloxicam inhibits osteosarcoma growth, invasiveness and metastasis by COX-2-dependent and independent routes. Carcinogenesis. 27:584-92. (Pubitemid 43378898)
    • (2006) Carcinogenesis , vol.27 , Issue.3 , pp. 584-592
    • Naruse, T.1    Nishida, Y.2    Hosono, K.3    Ishiguro, N.4
  • 29
    • 0035084176 scopus 로고    scopus 로고
    • Intestinal luminal pH in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugs
    • DOI 10.1136/gut.48.4.571
    • H in inflammatory bowel disease: Possible determinants and implications for therapy with aminosalicylates and other drugs. Gut. 48:571-7. (Pubitemid 32234805)
    • (2001) Gut , vol.48 , Issue.4 , pp. 571-577
    • Nugent, S.G.1    Kumar, D.2    Rampton, D.S.3    Evans, D.F.4
  • 30
    • 79953245183 scopus 로고    scopus 로고
    • The Merck Index: An encyclopedia of chemicals, drugs and biologicals. New Jersey: Merck and Co
    • O'Neil, M.J. (2006). The Merck Index: An encyclopedia of chemicals, drugs and biologicals. New Jersey: Merck and Co., INC.
    • INC. , vol.2006
    • O'Neil, M.J.1
  • 31
    • 34548214206 scopus 로고    scopus 로고
    • Therapeutic opportunities in colon specific drug delivery system
    • Patel, M., Shah, T., Amin, A. (2007). Therapeutic opportunities in colon specific drug delivery system. Crit Rev Ther Drug Carrier Syst. 24:147-202.
    • (2007) Crit Rev Ther Drug Carrier Syst , Issue.24 , pp. 147-202
    • Patel, M.1    Shah, T.2    Amin, A.3
  • 33
    • 46949102807 scopus 로고    scopus 로고
    • Wet process-induced phase-transited drug delivery system: A means for achieving osmotic, controlled, and level A IVIVC for poorly water-soluble drug
    • DOI 10.1080/03639040801911032, PII 793987968
    • Philip, A., Pathak, K. (2008a). Wet process-induced phase-transited drug delivery system: A means for achieving osmotics, controlled and level A IVIVC for poorly water soluble drug. Drug Dev Ind Pharm. 34:735-43. (Pubitemid 351962346)
    • (2008) Drug Development and Industrial Pharmacy , vol.34 , Issue.7 , pp. 735-743
    • Philip, A.K.1    Pathak, K.2
  • 34
    • 64349120146 scopus 로고    scopus 로고
    • In situ formed phase transited drug delivery system of ketoprofen for achieving osmotic, controlled and level A in vitro in vivo correlation
    • Philip, A.K., Pathak, K. (2008b). In situ formed phase transited drug delivery system of ketoprofen for achieving osmotic, controlled and level A in vitro in vivo correlation. Indian J Pharm Sci. 70: 745-53.
    • (2008) Indian J Pharm Sci , vol.70 , pp. 745-753
    • Philip, A.K.1    Pathak, K.2
  • 35
    • 0038155213 scopus 로고    scopus 로고
    • A novel pH- and time-dependent system for colonic drug delivery
    • DOI 10.1081/DDC-120021315
    • H- and Time-Dependent system for colonic drug delivery. Drug Dev Ind Pharm. 29: 661-7. (Pubitemid 36835159)
    • (2003) Drug Development and Industrial Pharmacy , vol.29 , Issue.6 , pp. 661-667
    • Qi, M.1    Wang, P.2    Wu, D.3
  • 36
    • 0037464333 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs in colorectal cancer: From prevention to therapy
    • DOI 10.1038/sj.bjc.6600829
    • Ricchi, P., Zarrilli, R., Di Palma, A., Acquaviva, A.M. (2003). Nonsteroidal anti-inflammatory drugs in colorectal cancer: From prevention to therapy. Br J Cancer. 88:803-7. (Pubitemid 36520863)
    • (2003) British Journal of Cancer , vol.88 , Issue.6 , pp. 803-807
    • Ricchi, P.1    Zarrilli, R.2    Di Palma, A.3    Acquaviva, A.M.4
  • 37
    • 37849189719 scopus 로고    scopus 로고
    • PH-independent drug release of an extremely poorly soluble weakly acidic drug from multiparticulate extended release formulations
    • DOI 10.1016/j.ejpb.2006.07.001, PII S0939641106001615
    • H-independent drug release of an extremely poorly soluble weakly acidic drug from multiparticulate extended release formulations. Eur J Pharm Biopharm. 65:78-84. (Pubitemid 44827687)
    • (2007) European Journal of Pharmaceutics and Biopharmaceutics , vol.65 , Issue.1 , pp. 78-84
    • Riis, T.1    Bauer-Brandl, A.2    Wagner, T.3    Kranz, H.4
  • 38
    • 3242687725 scopus 로고    scopus 로고
    • Different HPMC viscosity grades as coating agents for an oral time and/or site-controlled delivery system: A study on process parameters and in vitro performances
    • DOI 10.1016/j.ejps.2004.05.002, PII S0928098704001319
    • Sangalli, M.E., Maroni, A., Foppoli, A., Zema, L., Giordano, F., Gazzaniga, A. (2004). Different HPMC viscosity grades as coating agents for an oral time and / or site-controlled delivery system: A study on process parameters and in vitro performances. Eur J Pharm Sci. 22:469-76. (Pubitemid 38953906)
    • (2004) European Journal of Pharmaceutical Sciences , vol.22 , Issue.5 , pp. 469-476
    • Sangalli, M.E.1    Maroni, A.2    Foppoli, A.3    Zema, L.4    Giordano, F.5    Gazzaniga, A.6
  • 39
    • 0035907163 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of an oral system for time and/or site-specific drug delivery
    • DOI 10.1016/S0168-3659(01)00291-7, PII S0168365901002917
    • Sangalli, M.E., Maroni, A., Zema, L., Busetti, C., Giordano, F., Gazzaniga, A. (2001). In vitro and in vivo evaluation of an oral system for time and / or site-specific drug delivery.J Control Rel. 73:103-10. (Pubitemid 32409351)
    • (2001) Journal of Controlled Release , vol.73 , Issue.1 , pp. 103-110
    • Sangalli, M.E.1    Maroni, A.2    Zema, L.3    Busetti, C.4    Giordano, F.5    Gazzaniga, A.6
  • 41
    • 38749104628 scopus 로고    scopus 로고
    • Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma
    • Seong-Hee, K., Choi, G.J., Lee, J.H., Yoon, A.H., Soo-Jeong, L., Kim, S.H. (2008). Differential effects of selective cyclooxygenase-2 inhibitors in inhibiting proliferation and induction of apoptosis in oral squamous cell carcinoma. Oncol Rep. 19:425-33. (Pubitemid 351176104)
    • (2008) Oncology Reports , vol.19 , Issue.2 , pp. 425-433
    • Ko, S.-H.1    Choi, G.J.2    Lee, J.H.3    Han, Y.A.4    Lim, S.-J.5    Kim, S.H.6
  • 43
    • 0031445902 scopus 로고    scopus 로고
    • The use of pharmacoscintigraphy to focus the development strategy for a novel 5
    • ASA colon targeting system ("TIME CLOCK®" system
    • Steed, K.P., Hooper, G., Monti, N., Benedetti, M.S., Fornasini, G., Wilding, I.R. (1997). The use of pharmacoscintigraphy to focus the development strategy for a novel 5-ASA colon targeting system ("TIME CLOCK®" system). J Control Rel. 49:115-22.
    • (1997) J Control Rel , vol.49 , pp. 115-122
    • Steed, K.P.1    Hooper, G.2    Monti, N.3    Benedetti, M.S.4    Fornasini, G.5    Wilding, I.R.6
  • 45
    • 0034600282 scopus 로고    scopus 로고
    • Preferential inhibition of cyclooxygenase-2 by meloxicam in human rheumatoid synoviocytes
    • DOI 10.1016/S0014-2999(00)00163-1, PII S0014299900001631
    • Tsubouchi, Y., Sano, H., Yamada, R., Hashiramoto, A., Kohno, M., Kusaka, Y., Kondo, M. (2000a). Preferential inhibition of cyclooxygenase-2 by meloxicam in human rheumatoid synoviocytes. Eur J Pharmacol. 395:255-63. (Pubitemid 30254376)
    • (2000) European Journal of Pharmacology , vol.395 , Issue.3 , pp. 255-263
    • Tsubouchi, Y.1    Sano, H.2    Yamada, R.3    Hashiramoto, A.4    Kohno, M.5    Kusaka, Y.6    Kondo, M.7
  • 46
    • 79953253894 scopus 로고    scopus 로고
    • Formulation development and in vivo characterization of solubility enhanced gliclazide tablets
    • Vijayalakshmi, P., Devi, V.K., Devi, K., Benson, M.K., Srinagesh, S. (2008). Formulation development and in vivo characterization of solubility enhanced gliclazide tablets. Curr trends Biotech Pharm. 2:456-61.
    • (2008) Curr trends Biotech Pharm , vol.2 , pp. 456-461
    • Vijayalakshmi, P.1    Devi, V.K.2    Devi, K.3    Benson, M.K.4    Srinagesh, S.5
  • 47
    • 38349086771 scopus 로고    scopus 로고
    • In vitro and in vivo studies of pectin/ethylcellulose film coated pellets of 5-fluorouracil for colonic targeting
    • Wei, H., Qing, D., De-Ying, C., Bai, X., Li-Fang, F. (2008). In vitro and in vivo studies of pectin/ethylcellulose film coated pellets of 5-fluorouracil for colonic targeting. J Pharm Pharmacol. 60: 35-44.
    • (2008) J Pharm Pharmacol , vol.60 , pp. 35-44
    • Wei, H.1    Qing, D.2    De-Ying, C.3    Bai, X.4    Li-Fang, F.5
  • 48
    • 0033850086 scopus 로고    scopus 로고
    • COX-1 and COX-2 products in the gut: Therapeutic impact of COX-2 inhibitors
    • Accessed 15 August 2009
    • Whittle, B.J.R. (2000). COX-1 and COX-2 products in the gut: Therapeutic impact of COX-2 inhibitors. Gut. 47:320-5. www.ich.org. Accessed 15 August 2009.
    • (2000) Gut , vol.47 , pp. 320-325
    • Whittle, B.J.R.1
  • 49
    • 34548533057 scopus 로고    scopus 로고
    • Effects of meloxicam on vascular endothelial growth factor and angiopoietin-2 expression in colon carcinoma cell line HT-29
    • Zhang, N., Tao, K., Huang, T. (2007). Effects of meloxicam on vascular endothelial growth factor and angiopoietin-2 expression in colon carcinoma cell line HT-29. J Huazhong Univ Sci Tech Med Sci. 27:399-402.
    • (2007) J Huazhong Univ Sci Tech Med Sci , vol.27 , pp. 399-402
    • Zhang, N.1    Tao, K.2    Huang, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.