Prevalence of molecular markers of anti-malarial drug resistance in Plasmodium vivax and Plasmodium falciparum in two districts of Nepal

Malaria Journal

Volumn 10, Issue , 2011, Pages

  Ranjitkar, Samir ^a   Schousboe, Mette L ^a   Thomsen, Thomas Thyge ^a   Adhikari, Madhav ^b   Kapel, Christian Mo ^c   Bygbjerg, Ib C ^a   Alifrangis, Michael ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b TRIBHUVAN UNIVERSITY   (Nepal)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; MOLECULAR MARKER; PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; PROTOZOAL PROTEIN; PYRIMETHAMINE; SULFADOXINE; SULFADOXINE-PYRIMETHAMINE;

ADOLESCENT; ADULT; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; BLOOD SAMPLING; CHILD; FEMALE; GENE MUTATION; HAPLOTYPE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NEPAL; NONHUMAN; PARASITE; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM VIVAX MALARIA; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; PREVALENCE; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; DRUG COMBINATION; DRUG EFFECT; DRUG RESISTANCE; GENETICS; ISOLATION AND PURIFICATION; PARASITOLOGY;

ANTIMALARIALS; ARTEMISININS; CHLOROQUINE; DRUG COMBINATIONS; DRUG RESISTANCE; HUMANS; MALARIA, FALCIPARUM; MALARIA, VIVAX; NEPAL; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; POLYMERASE CHAIN REACTION; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS; PYRIMETHAMINE; SULFADOXINE;

EID: 79953239538     PISSN: None     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-10-75     Document Type: Article

References (54)

1. Malaria-Disease Burden in SEA Region. http://www.searo.who.int/EN/ Section10/Section21/Section340-4018.htm
2. Ranking of elimination feasibility between malaria-endemic countries. AJ Tatem DL Smith PW Gething CW Kabaria RW Snow SI Hay, Lancet 2010 376 1579 1591 10.1016/S0140-6736(10)61301-3 21035838
3. Nepal-Malaria Situation in SEAR Countries. http://www.searo.who.int/en/ Section10/Section21/Section340.htm
4. National Malaria Treatment Protocol. Epidemiology & Disease Control Division, Department of Health Services, Ministry of Health & Population, Government of Nepal, 2009
5. The Internal assessment of Malaria and Kala-azar Control Activities 2004, 2005 and 2006. Epidemiology & Disease Control Division, Department of Health Services, Ministry of Health & Population, Government of Nepal, 2007
6. Drug resistance in malaria. U Farooq RC Mahajan, J Vector Borne Dis 2004 41 45 53 15672556 (Pubitemid 40091456)
7. Antimalarial drug resistance. NJ White, J Clin Invest 2004 113 1084 1092 15085184 (Pubitemid 38544090)
8. Epidemiology of drug-resistant malaria. C Wongsrichanalai AL Pickard WH Wernsdorfer SR Meshnick, Lancet Infect Dis 2002 2 209 218 10.1016/S1473-3099(02) 00239-6 11937421 (Pubitemid 34464751)
9. An inventory on malaria drug resistance in Bangladesh, Bhutan, India and Nepal. PM Wijeyaratne N Valecha AB Joshi D Singh S Pandey, Environment Health Project Activity Report 2005 130 1 43
10. Assessment of therapeutic efficacy of anti-malarial drug against uncomplicated Plasmodium falciparum malaria in the Indo-Nepal Border Jhapa district (Nepal) & Darjeeling district, West Bengal (India). PB Chand PM Wijeyaratne S Pandey MA Ansari N Valecha, Journal of Nepal Health Research Council 2003 1 59
11. Molecular markers of in vivo Plasmodium vivax resistance to amodiaquine plus sulfadoxine-pyrimethamine: mutations in pvdhfr and pvmdr1. J Marfurt F de Monbrison S Brega L Barbollat A Sie M Goroti JC Reeder HP Beck S Picot B Genton, J Infect Dis 2008 198 409 417 10.1086/589882 18582193
12. Analysis of pfcrt point mutations and chloroquine susceptibility in isolates of Plasmodium falciparum. R Durand S Jafari J Vauzelle JF Delabre Z Jesic J Le Bras, Mol Biochem Parasitol 2001 114 95 102 10.1016/S0166-6851(01) 00247-X 11356518 (Pubitemid 32453219)
13. A molecular marker for chloroquine-resistant falciparum malaria. A Djimde OK Doumbo JF Cortese K Kayentao S Doumbo Y Diourte A Dicko X Su T Nomura DA Fidock, NEJM 2001 344 257 263 10.1056/NEJM200101253440403 11172152 (Pubitemid 32108530)
14. Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine. DC Warhurst, Malar J 2003 2 31 10.1186/1475-2875-2-31 14599295
15. The mechanisms of resistance to antimalarial drugs in Plasmodium falciparum. J Le Bras R Durand, Fundamental & Clinical Pharmacology 2003 17 147 153 (Pubitemid 36513205)
16. Analysis of the Plasmodium vivax dihydrofolate reductase-thymidylate synthase gene sequence. P Eldin de Pqcoulas LK Basco R Tahar T Ouatas A Mazabraud, Gene 1998 211 177 185 10.1016/S0378-1119(98)00118-8 9573357 (Pubitemid 28200939)
17. Sulfadoxine resistance in Plasmodium vivax is associated with a specific amino acid in dihydropteroate synthase at the putative sulfadoxine-binding site. M Korsinczky K Fischer N Chen J Baker K Rieckmann Q Cheng, Antimicrob Agents Chemother 2004 48 2214 2222 10.1128/AAC.48.6.2214-2222.2004 15155224 (Pubitemid 38691621)
18. Amino acid changes linked to pyrimethamine resistance in the dihydrofolate reductase-thymidylate synthase gene of Plasmodium falciparum. AF Cowman MJ Morry BA Biggs GA Cross SJ Foote, Proc Natl Acad Sci USA 1988 85 9109 9113 10.1073/pnas.85.23.9109 3057499 (Pubitemid 19001849)
19. Sulfadoxine resistance in the human malaria parasite Plasmodium falciparum is determined by mutations in dihydropteroate synthetase and an additional factor associated with folate utilization. P Wang M Read PFG Sims JE Hyde, Mol Microbiol 1997 23 979 986 10.1046/j.1365-2958.1997.2821646.x 9076734 (Pubitemid 27096733)
20. Antifolates can have a role in the treatment of Plasmodium vivax. VN Hawkins H Joshi K Rungsihirunrat K Na-Bangchang CH Sibley, Trends Parasitol 2007 23 213 222 10.1016/j.pt.2007.03.002 17368986 (Pubitemid 46621225)
21. Short Report: Prevalence of antimalarial drug resistance mutations in Plasmodium vivax and P. falciparum from a malaria-endemic area of Pakistan. L Khatoon FN Baliraine M Bonizzoni SA Malik G Yan, Am J Trop Med Hyg 2009 81 525 528 19706926
22. Therapeutic efficacy of chloroquine in Plasmodium vivax from areas with different epidemiological patterns in India and their Pvdhfr gene mutation pattern. N Valecha H Joshi A Eapen J Ravinderan A Kumar KP Surendra P Ringwald, Trans R Soc Trop Med Hyg 2006 100 831 837 10.1016/j.trstmh.2005.11.012 16513151 (Pubitemid 43986288)
23. Plasmodium vivax dhfr and dhps mutations in isolates from Madagascar and therapeutic response to sulphadoxine-pyrimethamine. C Barnadas M Tichit C Bouchier A Ratsimbasoa L Randrianasolo R Raherinjafy M Jahevitra S Picot D Ménard, Malar J 2008 7 1 11 10.1186/1475-2875-7-35 18173836
24. Amino acid mutations in Plasmodium vivax DHFR and DHPS from several geographical regions and susceptibility to antifolate drugs. A Auliff DW Wilson B Russel QI Goa N Chen L Anh J Maguire D Bel MT O'Neil QIN CCheng, Am J Trop Med Hyg 2006 75 617 621 17038682 (Pubitemid 46941264)
25. Increasing prevalence of wildtypes in the dihydrofolate reductase gene of Plasmodium falciparum in an area with high levels of sulfadoxine/pyrimethamine resistance after introduction of treated bed nets. M Alifrangis MM Lemnge AM Ronn, Am J Trop Med Hyg 2003 69 238 243 14628937
26. Comparison of artemether-lumefantrine with sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Eastern Nepal. S Thapa J Hollander M Linehan J Cox-Singh MB Bista GD Thakur WA Davis TME Davis, Am J Trop Med Hyg 2007 77 423 430 17827354 (Pubitemid 351844313)
27. PCR and strain identification in Plasmodium falciparum. J Wooden S Kyes CH Sibley, Parasitol Today 1993 9 303 305 10.1016/0169-4758(93)90131-X 15463789 (Pubitemid 23217730)
28. Stained smears as a source of DNA. J Alger MC Acosta C Lozano C Velasquez LA Labrada, Mem Inst Oswaldo Cruz 1996 91 589 591 10.1590/S0074- 02761996000500009 9137743
29. Pre-elimination stage of malaria in Sri Lanka: assessing the level of hidden parasites in the population. R Rupika A Michael A Priyanie K Flemming, Malar J 2010 9 1 6 10.1186/1475-2875-9-1 20043863
30. High sensitivity of detection of human malaria parasites by the use of nested polymerase chain reaction. G Snounou S Thaithongc KN Browna, Mol Biochem Parasitol 1993 61 315 320 10.1016/0166-6851(93)90077-B 8264734
31. Chloroquine resistant Plasmodium vivax: in vitro characterisation and association with molecular polymorphisms. R Suwanarusk B Russell M Chavchich F Chalfein E Kenangalem V Kosaisavee B Prasetyorini KA Piera M Barends A Brockman, PLoS One 2007 2 1 9 10.1371/journal.pone.0001089 (Pubitemid 351566688)
32. Island-wide diversity in single nucleotide polymorphisms of the Plasmodium vivax dihydrofolate reductase and dihydropteroate synthetase genes in Sri Lanka. ML Schousboe RS Rajakaruna A Salanti HC Hapuarachchi GN Galappaththy IC Bygbjerg PH Amerasinghe F Konradsen M Alifrangis, Malar J 2007 6 28 10.1186/1475-2875-6-28 17349045
33. A simple, high-throughput method to detect Plasmodium falciparum single nucleotide polymorphisms in the dihydrofolate reductase, dihydropteroate synthase, and P. falciparum chloroquine resistance transporter genes using polymerase chain reaction-and enzyme-linked immunosorbent assay-based technology. M Alifrangis S Enosse R Pearce C Drakeley C Roper IF Khalil WMMM Nkya AM Ronn TG Theander IC Bygbjerg, Am J Trop Med Hyg 2005 72 155 162 15741552 (Pubitemid 41278900)
34. Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum. MT Duraisingh C Roper D Walliker DC Warhurst, Mol Microbiol 2000 36 955 961 10.1046/j.1365-2958.2000.01914.x 10844681 (Pubitemid 30326539)
35. Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria. GS Humphreys I Merinopoulos J Ahmed CJM Whitty TK Mutabingwa CJ Sutherland RL Hallett, Antimicrob Agents Chemother 2007 51 991 997 10.1128/AAC.00875-06 17194834 (Pubitemid 46355285)
36. Malaria-Drug Resistance. http://www.searo.who.int/EN/Section10/Section21/ Section340-4039.htm
37. Real-time PCR assay for rapid detection and analysis of PfCRT haplotypes of chloroquine-resistant Plasmodium falciparum isolates from India. J Keen GA Farcas K Zhong S Yohanna MW Dunne KC Kain, J Clin Microbiol 2007 45 2889 2893 10.1128/JCM.02291-06 17609321 (Pubitemid 47417331)
38. Return of chloroquine antimalarial efficacy in Malawi. MK Laufer PC Thesing ND Eddington R Masonga FK Dzinjalamala SL Takala TE Taylor CV Plowe, NEJM 2006 355 1959 1966 10.1056/NEJMoa062032 17093247 (Pubitemid 44708015)
39. Five-year surveillance of molecular markers of Plasmodium falciparum antimalarial drug resistance in Korogwe District, Tanzania: accumulation of the 581G mutation in the P. falciparum dihydropteroate synthase gene. M Alifrangis JP Lusingu B Mmbando MB Dalgaard LS Vestergaard D Ishengoma IF Khalil TG Theander MM Lemnge IC Bygbjerg, Am J Trop Med Hyg 2009 80 523 527 19346369
40. The role of pfmdr1 in Plasmodium falciparum tolerance to artemether lumefantrine in Africa. C Sisowath PE Ferreira LY Bustamante S Dahlstrom A Martensson A Bjorkman S Krishna JP Gil, Trop Med Int Health 2007 12 736 742 10.1111/j.1365-3156.2007.01843.x 17550470 (Pubitemid 46872790)
41. Characterisation of pvmdr1 and pvdhfr genes associated with chemoresistance in Brazilian Plasmodium vivax isolates. BE Gama NKA Oliveira JM Souza CT Daniel-Ribeiro MF Ferreira-da-Cruz, Mem Inst Oswaldo Cruz 2009 104 1009 1011 10.1590/S0074-02762009000700012 20027469
42. Plasmodium vivax resistance to chloroquine in Madagascar: clinical efficacy and polymorphisms in pvmdr1 and pvcrt-o genes. C Barnadas A Ratsimbasoa M Tichit C Bouchier M Jahevitra S Picot D Ménard, Antimicrob Agents Chemother 2008 52 4233 10.1128/AAC.00578-08 18809933
43. Plasmodium falciparum isolates in India exhibit a progressive increase in mutations associated with sulfadoxine-pyrimethamine resistance. A Ahmed D Bararia S Vinayak M Yameen S Biswas V Dev A Kumar MA Ansari YD Sharma, Antimicrob Agents Chemother 2004 48 879 889 10.1128/AAC.48.3.879-889.2004 14982779 (Pubitemid 38280339)
44. Prevalence of mutations associated with higher levels of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Car Nicobar Island and Assam, India. A Ahmed V Lumb MK Das V Dev, Antimicrob Agents Chemother 2006 50 3934 3938 10.1128/AAC.00732-06 16982787 (Pubitemid 44684921)
45. A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria. S Picot P Olliaro F de Monbrison AL Bienvenu RN Price P Ringwald, Malar J 2009 8 89 10.1186/1475-2875-8-89 19413906
46. Novel point mutations in sulfadoxine resistance genes of Plasmodium falciparum from India. S Garg V Saxena S Kanchan P Sharma S Mahajan D Kochar A Das, Acta Trop 2009 110 75 79 10.1016/j.actatropica.2009.01.009 19283899
47. Prevalence of mutations associated with antimalarial drugs in Plasmodium falciparum isolates prior to the introduction of sulphadoxine-pyrimethamine as first-line treatment in Iran. Z Sedigheh A Mandana R Ahmad D Navid, Malar J 2007 6 148 10.1186/1475-2875-6-148 17999755
48. Therapeutic efficacy of antimalarial drugs along the eastern Indo-Nepal border: a cross-border collaborative study. PM Wijeyaratne PB Chand N Valecha B Shahi T Adak MA Ansari J Jha S Pandey S Bannerjee MB Bista, Trans R Soc Trop Med Hyg 2005 99 423 429 10.1016/j.trstmh.2004.09.011 15837354 (Pubitemid 40521340)
49. Similar trends of pyrimethamine resistance-associated mutations in Plasmodium vivax and P. falciparum. MT Alam H Bora PK Bharti MA Saifi MK Das V Dev A Kumar N Singh AP Dash B Das, Antimicrob Agents Chemother 2007 51 857 863 10.1128/AAC.01200-06 17194833 (Pubitemid 46355267)
50. Association of genetic mutations in Plasmodium vivax dhfr with resistance to sulfadoxine-pyrimethamine: geographical and clinical correlates. M Imwong S Pukrittakayamee S Looareesuwan G Pasvol J Poirreiz NJ White G Snounou, Antimicrob Agents Chemother 2001 45 3122 3127 10.1128/AAC.45.11.3122-3127.2001 11600366 (Pubitemid 32988838)
51. Comparative evaluation of microscopy and polymerase chain reaction (PCR) for the diagnosis in suspected malaria patients of Nepal. K Parajuli S Hanchana M Imwong S Pukrittayakayamee P Ghimire, Nepal Med Coll J 2009 11 23 27 19769232
52. Characteristics and risk factors of Plasmodium falciparum malaria in Eastern and Central Nepal. MR Banjara W Sirawaraporn S Petmitr M Imwong AB Joshi P Chavalitshewinkoon-Petmitr, Kathmandu University Medical Journal 2010 7 378 382 10.3126/kumj.v7i4.2758
53. Nepal-Malaria Situation in SEAR Countries. http://www.who.int/malaria/ publications/country-profiles/2008/mal2008-nepal-en.pdf
54. Department of Health Services, Ministry of Health & Population, Government of Nepal, 2010 Annual Report 2008/2009