Extrasynaptic GABAA receptors in the nucleus accumbens are necessary for alcohol drinking

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 12, 2011, Pages 4699-4700

  Olsen, Richard W ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; MESSENGER RNA; SMALL INTERFERING RNA; SUCROSE;

DOPAMINERGIC NERVE CELL; DRINKING BEHAVIOR; GENE DELETION; GENETIC ENGINEERING; HUMAN; NONHUMAN; NOTE; NUCLEUS ACCUMBENS; PHENOTYPE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; VENTRAL TEGMENTUM; ADENOVIRUS; ANIMAL; GENE SILENCING; GENETICS; LONG EVANS RAT; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; RAT; REPRODUCIBILITY; SYNAPSE; THALAMUS DORSOMEDIAL NUCLEUS;

ADENOVIRIDAE; ADMINISTRATION, ORAL; ALCOHOL DRINKING; ANIMALS; GENE KNOCKDOWN TECHNIQUES; MALE; MEDIODORSAL THALAMIC NUCLEUS; NUCLEUS ACCUMBENS; RATS; RATS, LONG-EVANS; RECEPTORS, GABA-A; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; RNA, SMALL INTERFERING; SUCROSE; SYNAPSES;

EID: 79953223353     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1102818108     Document Type: Note

References (20)

1. A receptors in the nucleus accumbens dorsomedial shell contribute to alcohol intake. Proc Natl Acad Sci USA 108:4459-4464.
2. Rewal M, et al. (2009) Alpha4-containing GABA(A) receptors in the nucleus accumbens mediate moderate intake of alcohol. J Neurosci 29:543-549.
3. Jeanblanc J, et al. (2009) Endogenous BDNF in the dorsolateral striatum gates alcohol drinking. J Neurosci 29:13494-13502.
4. Sundstrom-Poromaa I, et al. (2002) Hormonally regulated alpha(4)beta(2)delta GABA(A) receptors are a target for alcohol. Nat Neurosci 5:721-722.
5. Wallner M, Hanchar HJ, Olsen RW (2003) Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc Natl Acad Sci USA 100:15218-15223. (Pubitemid 37518043)
6. Wei W, Faria LC, Mody I (2004) Low ethanol concentrations selectively augment the tonic inhibition mediated by delta subunit-containing GABA(A) receptors in hippocampal neurons. J Neurosci 24:8379-8382. (Pubitemid 39280816)
7. Wallner M, Hanchar HJ, Olsen RW (2006) Low dose acute alcohol effects on GABA. A receptor subtypes. Pharmacol Ther 112:513-528.
8. Liang J, et al. (2007) Mechanisms of reversible GABA(A) receptor plasticity after ethanol intoxication. J Neurosci 27:12367-12377. (Pubitemid 350085483)
9. Santhakumar V, Wallner M, Otis TS (2007) Ethanol acts directly on extrasynaptic subtypes of GABA(A) receptors to increase tonic inhibition. Alcohol 41:211-221. (Pubitemid 46970812)
10. Paul SM (2006) Alcohol-sensitive GABA receptors and alcohol antagonists. Proc Natl Acad Sci USA 103:8307-8308.
11. Homanics GE, et al. (1997) Gene knockout of the alpha6 subunit of the gamma-aminobutyric acid type A receptor: Lack of effect on responses to ethanol, pentobarbital, and general anesthetics. Mol Pharmacol 51:588-596. (Pubitemid 27172985)
12. Mihalek RM, et al. (2001) GABA(A)-receptor δ subunit knockout mice have multiple defects in behavioral responses to ethanol. Alcohol Clin Exp Res 25:1708-1718. (Pubitemid 34033139)
13. Chandra D, et al. (2006) GABA(A) receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci USA 103:15230-15235. (Pubitemid 44583193)
14. Chandra D, et al. (2008) Normal acute behavioral responses to moderate/high dose ethanol in GABA(A) receptor alpha 4 subunit knockout mice. Alcohol Clin Exp Res 32:10-18. (Pubitemid 350293908)
15. Brickley SG, Revilla V, Cull-Candy SG, Wisden W, Farrant M (2001) Adaptive regulation of neuronal excitability by a voltage-independent potassium conductance. Nature 409:88-92. (Pubitemid 32098630)
16. Tan KR, et al. (2010) Neural bases for addictive properties of benzodiazepines. Nature 463:769-774.
17. Lüscher C, Ungless MA (2006) The mechanistic classification of addictive drugs. PLoS Med 3:e437.
18. Koob GF, et al. (1998) Neurocircuitry targets in ethanol reward and dependence. Alcohol Clin Exp Res 22:3-9. (Pubitemid 28139190)
19. Saal D, Dong Y, Bonci A, Malenka RC (2003) Drugs of abuse and stress trigger a common synaptic adaptation in dopamine neurons. Neuron 37:577-582. (Pubitemid 36262980)
20. Heikkinen AE, Moykkynen TP, Korpi ER (2009) Long-lasting modulation of glutamatergic transmission in VTA dopamine neurons after a single does of benzodiazepine agonists. Neuropsychopharmacology 34:290-298.