Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 7, 2011, Pages 2136-2144

  Li, Tiehai ^a   Guo, Lina ^a   Zhang, Yan ^a   Wang, Jiajia ^a   Zhang, Zhenxing ^a   Li, Jing ^a   Zhang, Wenpeng ^b   Lin, Jianping ^a   Zhao, Wei ^a   Wang, Peng George ^a,b  

^a NANKAI UNIVERSITY   (China)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

Glycosidase; Inhibitors; Tetrahydroimidazopyridines

Indexed keywords

2 (3,3 DIMETHYLBUTYL) 5 (HYDROXYMETHYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE 6,7,8 TRIOL; 2,3,4,6 TETRA O BENZYL 1,5 DIDEOXY 1 [(2',2' DIMETHOXYETHYL)IMINO] 1,5 IMINO DEXTRO GLUCITOL; 2,3,4,6 TETRA O BENZYL 5 DEHYDRO 5 OXO DEXTRO GLUCONAMIDE; 2,3,4,6 TETRA O BENZYL DEXTRO GLUCONAMIDE; 2,3,4,6 TETRA O BENZYL DEXTRO GLUCONOLACTAM; 2,3,4,6 TETRA O BENZYL DEXTRO GLUCONOLACTONE; 2,3,4,6 TETRA O BENZYL DEXTRO GLUCOPYRANOSIDE; 2,3,4,6 TETRA O BENZYL DEXTRO GLUCOTHIONOLACTAM; 5 (HYDROXYMETHYL) 2 (2 PHENYLETHYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE 6,7,8 TRIOL; 5 (HYDROXYMETHYL) 2 (4 METHOXYPHENETHYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE 6,7,8 TRIOL; 5 (HYDROXYMETHYL) 2 OCTYL 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE 6,7,8 TRIOL; 5 (HYDROXYMETHYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE 6,7,8 TRIOL; 6,7,8 TRIS(BENZYLOXY) 5 (BENZYLOXYMETHYL) 2 (BIPHENYL 4 YLETHYNYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 (BENZYLOXYMETHYL) 2 (OCT 1 YNYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 (BENZYLOXYMETHYL) 2 [(4 FLUOROPHENYL)ETHYNYL] 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 (BENZYLOXYMETHYL) 2 [(4 METHOXYPHENYL)ETHYNYL] 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 (BENZYLOXYMETHYL) 2 [(4 METHYLPHENYL)ETHYNYL] 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 [(BENZYLOXY)METHYL] 2 (2 PHENYLETHYNYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 [(BENZYLOXY)METHYL] 2 (3,3 DIMETHYLBUT 1 YNYL) 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 [(BENZYLOXY)METHYL] 2 IODO 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; 6,7,8 TRIS(BENZYLOXY) 5 [(BENZYLOXY)METHYL] 5,6,7,8 TETRAHYDROIMIDAZO[1,2 A]PYRIDINE; BETA GLYCOSIDASE; BETA GLYCOSIDASE INHIBITOR; GLUCOSE DERIVATIVE; GLYCOSIDASE; GLYCOSIDASE INHIBITOR; IMIDAZOPYRIDINE DERIVATIVE; METHYL 2,3,4,6 TETRA O BENZYL ALPHA DEXTRO GLUCOPYRANOSIDE; TETRAHYDROIMIDAZOPYRIDINE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME INHIBITION; MOLECULAR DOCKING; STRUCTURE ACTIVITY RELATION;

BETA-GLUCOSIDASE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; IMIDAZOLES; KINETICS; MODELS, MOLECULAR; PLANT EXTRACTS; PRUNUS; PYRIDINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953215968     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.02.043     Document Type: Article

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