Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro

European Journal of Medicinal Chemistry

Volumn 46, Issue 5, 2011, Pages 1701-1705

  Pang, Xiaodong ^a   Zhang, Mingjun ^b   Zhou, Linxiang ^a   Xie, Fang ^b   Lu, Hong ^c   He, Wu ^c   Jiang, Shibo ^a,c   Yu, Long ^b   Zhang, Xinyi ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

^c NEW YORK BLOOD CENTER   (United States)

Author keywords

HIV 1IIIB infection; Peptidic inhibitor; PPIase activity; Surface plasmon resonance analysis; Virtual screening

Indexed keywords

CYCLOPHILIN INHIBITOR; PEPTIDYLPROLYL ISOMERASE; TRYPTOPHANYLGLYCYLPROLYL; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME ACTIVITY; HYDROGEN BOND; IC 50;

BINDING SITES; CELL LINE, TRANSFORMED; CYCLOPHILIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DISCOVERY; HIV INFECTIONS; HIV-1; HUMANS; MODELS, MOLECULAR; OLIGOPEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 79953214376     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.02.023     Document Type: Article

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