Comparative in vitro activities of the novel antibacterial finafloxacin against selected gram-positive and gram-negative bacteria tested in Mueller-Hinton broth and synthetic urine

Antimicrobial Agents and Chemotherapy

Volumn 55, Issue 4, 2011, Pages 1814-1818

  Dalhoff, Axel ^a   Stubbings, Will ^b   Schubert, Sabine ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^b MerLion Pharmaceuticals GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOGLYCOSIDE; CIPROFLOXACIN; CLAVULANIC ACID; FINAFLOXACIN; MACROLIDE; SULBACTAM; TAZOBACTAM; TETRACYCLINE;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BROTH DILUTION; ENTEROCOCCUS FAECALIS; ESCHERICHIA COLI; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IN VITRO STUDY; KLEBSIELLA PNEUMONIAE; MINIMUM INHIBITORY CONCENTRATION; MUELLER HINTON BROTH; NONHUMAN; OSMOLARITY; PH; PRIORITY JOURNAL; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS SAPROPHYTICUS; STREPTOCOCCUS AGALACTIAE; SYNTHETIC URINE; URINE;

ANTI-BACTERIAL AGENTS; CIPROFLOXACIN; CULTURE MEDIA; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; MICROBIAL SENSITIVITY TESTS;

EID: 79953211537     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00886-10     Document Type: Article

References (38)

1. Aagaard, J., P. O. Madsen, P. Rhodes, and T. Gasser. 1991. MICs of ciprofloxacin and trimethoprim for Escherichia coli: influence of pH, inoculum size and various body fluids. Infection 19(Suppl. 3):167-169.
2. Atkinson, S., and P. Williams. 2009. Quorum sensing and social networking in the microbial world. J. R. Soc. Interface 6:959-978.
3. Beenken, K. E., et al. 2004. Global gene expression in Staphylococcus aureus biofilms. J. Bacteriol. 186:4665-4684. (Pubitemid 38891030)
4. Bodey, G. P., V. Rodriguez, and S. Weaver. 1976. Pirbenicillin, a new semisynthetic penicillin with broad-spectrum activity. Antimicrob. Agents Chemother. 9:668-674.
5. Borrill, Z., C. Starkey, J. Vesttbo, and D. Singh. 2005. Reproducibility of exhaled breath condensate pH in chronic obstructive pulmonary disease. Eur. Respir. J. 25:269-274.
6. Clinical and Laboratory Standards Institute/NCCLS. 1999. Methods for determining bactericidal activity of antimicrobial agents, vol. 19, p. 18. Approved guideline M26-A. Clinical and Laboratory Standards Institute, Wayne, PA.
7. Clinical and Laboratory Standards Institute/NCCLS. 2001. Performance standards for antimicrobial susceptibility testing, vol. 21, p. 1. 11th informational supplement. M100-S11. Clinical and Laboratory Standards Institute, Wayne, PA.
8. Cotter, P. D., and C. Hill. 2003. Surviving the acid test: response of Gram-positive bacteria to low pH. Microbiol. Mol. Biol. Rev. 67:429-453.
9. Dalhoff, A., S. Schubert, and U. Ullmann. 2005. Effect of pH on the in vitro activity of and propensity for emergence of resistance to fluoroquinolones, macrolides, and a ketolide. Infection 33(Suppl. 2):36-43.
10. Eliopoulos, G. M., and C. T. Eliopoulos. 1993. Activity in vitro of the quinolones. In D. C. Hooper and J. S. Wolfson (ed.), Quinolone antibacterial agents, 2nd ed. ASM Press, Washington, DC.
11. Geske, G. D., J. O'Neill, and H. E. Blackwell. 2008. Expanding dialogues: from natural autoinducers to non-natural analogues that modulate quorum sensing in Gram-negative bacteria. Chem. Soc. Rev. 37:1432-1447.
12. Gitlin, N. 1990. Ascitic fluid acidosis in bacterial peritonitis: a poor prognostic sign? Hepatology 11:896-898.
13. Goodell, E. W., R. Lopez, and A. Tomasz. 1976. Suppression of lytic effect of beta-lactams on Escherichia coli and other bacteria. Proc. Natl. Acad. Sci. U. S. A. 73:3293-3297.
14. Griffith, D. P., D. M. Musher, and C. Itin. 1976. The primary cause of infection-induced urinary stones. Invest. Urol. 13:346-350.
15. Gudmundsson, A., H. Erlendsdottir, M. Gottfredsson, and S. Gudmundsson. 1991. Impact of pH and cationic supplementation on in vitro postantibiotic effect. Antimicrob. Agents Chemother. 35:2617-2624.
16. Hunt, J. F., et al. 2000. Endogenous airway acidification. Implications for asthma pathophysiology. Am. J. Respir. Crit. Care Med. 161:694-699.
17. Kalantzi, L., et al. 2006. Characterisation of the human upper gastrointestinal content under conditions simulating bioavailability/ bioequivalence studies. Pharm. Res. 23:165-176.
18. 2 and pH on inhibition of TEM-1 and other β-lactamases by penicillanic acid solutions. Antimicrob. Agents Chemother. 36:1870-1876.
19. Lorian, V. (ed.). 1996. Antibiotics in laboratory medicine, 4th ed. Williams & Wilkins Co., Baltimore, MD.
20. Miller, T., and S. Phillips. 1983. Effect of physiological manipulation on the chemotherapy of experimentally induced renal infection. Antimicrob. Agents Chemother. 23:422-428.
21. Minuth, J. N., D. M. Musher, and S. B. Thorsteinsson. 1976. Inhibition of the antibacterial activity of gentamicin by urine. J. Infect. Dis. 133:14-21.
22. Montuschi, P. 2007. Analysis of exhaled breath condensate in respiratory medicine: methodological aspects and potential clinical applications. Ther. Adv. Respir. Dis. 1:5-23.
23. Ojoo, J. C., S. A. Mulrennan, J. A. Kastelik, A. H. Morice, and A. E. Redington. 2005. Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis. Thorax 60:22-26.
24. O'Neill, E. O., et al. 2008. Novel Staphylococcus aureus biofilm phenotype mediated by the fibronectin-binding proteins, FnBPA and FnBPB. J. Bacteriol. 190:3835-3850.
25. Pandit, N. K. 2007. Introduction to the pharmaceutical sciences. Chapter 9: drug absorption. Lippincott Williams and Wilkins, Philadelphia, PA.
26. Papapetropoulou, M., J. Papavassiliou, and N. J. Legakis. 1983. Effect of the pH and osmolarity of urine on the antibacterial activity of gentamicin. J. Antimicrob. Chemother. 12:571-575.
27. Peddie, B. A., and S. T. Chambers. 1993. Effects of betaines and urine on the antibacterial activity of aminoglycosides. J. Antimicrob. Chemother. 31:481-488.
28. Resch, A., R. Rosenstein, C. Nerz, and F. Götz. 2005. Differential gene expression profiling Staphylococcus aureus cultivated under biofilm and planktonic conditions. Appl. Environ. Microbiol. 71:2663-2676.
29. Sabath, L. D. 1978. Six factors that increase the activity of antibiotics in vivo. Infection 6(Suppl. 1):67-71. (Pubitemid 9036989)
30. Sanders, C. C. 1983. Alzocillin: a new broad spectrum penicillin. J. Antimicrob. Chemother. 11(Suppl. B):21-31.
31. Sato, S., and H. Kobayashi. 2003. Bacterial responses to alkaline stress. Sci. Prog. 66:271-282.
32. Schaper, K. J., S. Schubert, and A. Dalhoff. 2005. Kinetics and quantification of anti bacterial effects of beta-lactams, macrolides, and quinolones against gram-positive and gram-negative RTI pathogens. Infection 33(Suppl. 2): 3-14.
33. Schlessinger, D. 1988. Failure of aminoglycoside antibiotics to kill anaerobic, low-pH, and resistant cultures. Clin. Microbiol. Rev. 1:54-59.
34. Schumann, W. 2007. Bacterial stress sensors. In S. K. Calderwood (ed.), Protein reviews: cell stress proteins, vol. 7. Springer Science and Business Media LLC, New York, NY.
35. Stickler, D. J., N. S. Morris, J. C. Robert, R. J. C. McLean, and C. Fuqua. 1998. Biofilms on indwelling urethral catheters produce quorum-sensing molecules in situ and in vitro. Appl. Environ. Microbiol. 64:3486-3490.
36. Thauvin-Eliopoulos, C., and G. M. Eliopoulos. 2003. Activity in vitro of the quinolones. In D. C. Hooper and J. S. Wolfson (ed.), Quinolone antibacterial agents, 3rd ed. ASM Press, Washington, DC.
37. Wisell, K. T., G. Kahlmeter, and C. G. Giskes. 2008. Trimethoprim and enterococci in urinary tract infections: new perspectives on an old issue. J. Antimicrob. Chemother. 62:35-40.
38. Yarwood, J. M., D. J. Bartels, E. M. Volper, and E. P. Greenberg. 2004. Quorum sensing in Staphylococcus aureus biofilms. J. Bacteriol. 186:1838-1850.