-
1
-
-
76449114805
-
-
Hilton, S.; Naud, S.; Caldwell, J.; Boxall, K.; Burns, S.; Anderson, V. E.; Antoni, L.; Allen, C. E.; Pearl, L. H.; Oliver, A. W.; Aherne, G. W.; Garrett, M. D.; Collins, Ian. Bioorg. Med. Chem. 2010, 707-718
-
(2010)
Bioorg. Med. Chem.
, pp. 707-718
-
-
Hilton, S.1
Naud, S.2
Caldwell, J.3
Boxall, K.4
Burns, S.5
Anderson, V.E.6
Antoni, L.7
Allen, C.E.8
Pearl, L.H.9
Oliver, A.W.10
Aherne, G.W.11
Garrett, M.D.12
Collins, Ian.13
-
2
-
-
71849097295
-
-
WO 2010051188.
-
Burgey, C. S.; Deng, Z. J.; Nguyen, D. N.; Paone, D. V.; Shaw, A. W. PCT Int. Appl. WO 2010051188. 2010.
-
(2010)
PCT Int. Appl.
-
-
Burgey, C.S.1
Deng, Z.J.2
Nguyen, D.N.3
Paone, D.V.4
Shaw, A.W.5
-
4
-
-
33745183136
-
-
Humphries, P. S.; Bailey, S.; Do, Q. T.; Kellum, J. H.; McClellan, G. A.; Wilhite, D. M. Tetrahedron Lett. 2006, 47, 5333-5336
-
(2006)
Tetrahedron Lett.
, vol.47
, pp. 5333-5336
-
-
Humphries, P.S.1
Bailey, S.2
Do, Q.T.3
Kellum, J.H.4
McClellan, G.A.5
Wilhite, D.M.6
-
5
-
-
70249140970
-
-
Zhang, Q.; Wang, D.; Wang, X.; Ding, K. J. Org. Chem. 2009, 74, 7187-7190
-
(2009)
J. Org. Chem.
, vol.74
, pp. 7187-7190
-
-
Zhang, Q.1
Wang, D.2
Wang, X.3
Ding, K.4
-
6
-
-
65949119347
-
-
Caron, S.; Do, N. M.; Sieser, J. E.; Whritenour, D. C.; Hill, P. D. Org. Process Res. Dev. 2009, 13, 324-330
-
(2009)
Org. Process Res. Dev.
, vol.13
, pp. 324-330
-
-
Caron, S.1
Do, N.M.2
Sieser, J.E.3
Whritenour, D.C.4
Hill, P.D.5
-
7
-
-
67650087564
-
-
Sreedhar, B.; Reddy, P. S.; Reddy, M. Synthesis 2009, 10, 1732-1738
-
(2009)
Synthesis
, vol.10
, pp. 1732-1738
-
-
Sreedhar, B.1
Reddy, P.S.2
Reddy, M.3
-
8
-
-
30844466213
-
-
Stadlbauer, W.; Taeubl, A. E.; Dang, H. V.; Reidlinger, C.; Zangger, K. J. Het. Chem. 2006, 43, 117-125
-
(2006)
J. Het. Chem.
, vol.43
, pp. 117-125
-
-
Stadlbauer, W.1
Taeubl, A.E.2
Dang, H.V.3
Reidlinger, C.4
Zangger, K.5
-
11
-
-
38849209107
-
-
Storz, T.; Bartberger, M. D.; Sukits, S.; Wilde, C.; Soukup, T. Synthesis 2008, 2, 201-214
-
(2008)
Synthesis
, vol.2
, pp. 201-214
-
-
Storz, T.1
Bartberger, M.D.2
Sukits, S.3
Wilde, C.4
Soukup, T.5
-
12
-
-
34250202185
-
-
Yin, J.; Xiang, B.; Huffman, M. A.; Raab, C. E.; Davies, I. W. J. Org. Chem. 2007, 72, 4554-4557
-
(2007)
J. Org. Chem.
, vol.72
, pp. 4554-4557
-
-
Yin, J.1
Xiang, B.2
Huffman, M.A.3
Raab, C.E.4
Davies, I.W.5
-
14
-
-
1642547595
-
-
Hayashida, M.; Honda, H.; Hamana, M. Heterocycles. 1990, 31, 1325-31
-
(1990)
Heterocycles.
, vol.31
, pp. 1325-31
-
-
Hayashida, M.1
Honda, H.2
Hamana, M.3
-
15
-
-
0024311240
-
-
LaMontagne, M. P.; Blumbergs, P.; Smith, D. C. J. Med. Chem. 1989, 32, 1728-32
-
(1989)
J. Med. Chem.
, vol.32
, pp. 1728-32
-
-
Lamontagne, M.P.1
Blumbergs, P.2
Smith, D.C.3
-
16
-
-
84986505728
-
-
Brana, M. F.; Rodriguez, M. L.; Lopez; Rodriguez, C.; Garrido-Pertierra, A. J. Het. Chem. 1986, 23, 1019-22
-
(1986)
J. Het. Chem.
, vol.23
, pp. 1019-22
-
-
Brana, M.F.1
Rodriguez, M.L.2
Lopez3
Rodriguez, C.4
Garrido-Pertierra, A.5
-
17
-
-
0020385718
-
-
Yousif, M. M.; Saeki, S.; Hamana, M. Chem Pharm Bull. 1982, 30, 2326-32
-
(1982)
Chem Pharm Bull.
, vol.30
, pp. 2326-32
-
-
Yousif, M.M.1
Saeki, S.2
Hamana, M.3
-
19
-
-
79953202405
-
-
3.
-
3.
-
-
-
-
20
-
-
78449267074
-
-
Londregan, A. T.; Jennings, S.; Wei, L. Org. Lett. 2010, 12, 5254-5257
-
(2010)
Org. Lett.
, vol.12
, pp. 5254-5257
-
-
Londregan, A.T.1
Jennings, S.2
Wei, L.3
-
23
-
-
60849137210
-
-
Kang, F. A.; Sui, Z.; Murray, W. V. Eur. J. Org. Chem. 2009, 4, 461-479
-
(2009)
Eur. J. Org. Chem.
, vol.4
, pp. 461-479
-
-
Kang, F.A.1
Sui, Z.2
Murray, W.V.3
-
24
-
-
37549031766
-
-
Wan, Z.; Wacharasindhu, S.; Levins, C. G.; Lin, M.; Keiko Tabei, K.; Mansour, T. S. J. Org. Chem. 2007, 72, 10194-10210
-
(2007)
J. Org. Chem.
, vol.72
, pp. 10194-10210
-
-
Wan, Z.1
Wacharasindhu, S.2
Levins, C.G.3
Lin, M.4
Keiko Tabei, K.5
Mansour, T.S.6
-
25
-
-
14544306016
-
-
Kang, F. A.; Kodah, J.; Guan, Q.; Li, X.; Murray, W. V. J. Org. Chem. 2005, 70, 1957-1960
-
(2005)
J. Org. Chem.
, vol.70
, pp. 1957-1960
-
-
Kang, F.A.1
Kodah, J.2
Guan, Q.3
Li, X.4
Murray, W.V.5
-
26
-
-
0344887064
-
-
Equilibrium acidities discussed in this article are measured in DMSO, as reported by Bordwell. For a review, see
-
Equilibrium acidities discussed in this article are measured in DMSO, as reported by Bordwell. For a review, see: Bordwell, F. G. Acc. Chem. Res. 1988, 21, 456-463
-
(1988)
Acc. Chem. Res.
, vol.21
, pp. 456-463
-
-
Bordwell, F.G.1
-
29
-
-
0034175546
-
-
Caron, S.; Do, M. N.; Sieser, J. E. Tetrahedron Lett. 2000, 41, 2299-2302
-
(2000)
Tetrahedron Lett.
, vol.41
, pp. 2299-2302
-
-
Caron, S.1
Do, M.N.2
Sieser, J.E.3
-
30
-
-
2542507637
-
-
Ferrer, M.; Sanchez-Baeza, F.; Messeguer, A. Tetrahedron 1997, 53, 15877-15888
-
(1997)
Tetrahedron
, vol.53
, pp. 15877-15888
-
-
Ferrer, M.1
Sanchez-Baeza, F.2
Messeguer, A.3
-
31
-
-
84919924493
-
-
For a review on the regioselectivity of nucleophilic addition onto activated pyridines, see:,. Hard-hard/soft-soft interactions during the nucleophilic addition transition state are proposed to influence regioselectivity in additions onto activated pyridines, and may work in concert with the proposed charge interaction
-
For a review on the regioselectivity of nucleophilic addition onto activated pyridines, see: Poddubnyi, I. S. Chem. Heterocycl. Compd. 1995, 31, 682-714. Hard-hard/soft-soft interactions during the nucleophilic addition transition state are proposed to influence regioselectivity in additions onto activated pyridines, and may work in concert with the proposed charge interaction
-
(1995)
Chem. Heterocycl. Compd.
, vol.31
, pp. 682-714
-
-
Poddubnyi, I.S.1
-
32
-
-
36849137094
-
-
See the Supporting Information section for LUMO density calculations and further explanation.
-
See the Supporting Information section for LUMO density calculations and further explanation. Fukui, K.; Yonezawa, T.; Shingu, H. J. Chem. Phys. 1952, 20, 722-725
-
(1952)
J. Chem. Phys.
, vol.20
, pp. 722-725
-
-
Fukui, K.1
Yonezawa, T.2
Shingu, H.3
-
33
-
-
36849118220
-
-
Fukui, K.; Yonezawa, T.; Nagata, C.; Shingu, H. J. Chem. Phys. 1954, 22, 1433-1442
-
(1954)
J. Chem. Phys.
, vol.22
, pp. 1433-1442
-
-
Fukui, K.1
Yonezawa, T.2
Nagata, C.3
Shingu, H.4
-
34
-
-
79953176549
-
-
Alternative bases (NaH, NaOtBu) and solvent (THF) were screened. No reaction occurred.
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Alternative bases (NaH, NaOtBu) and solvent (THF) were screened. No reaction occurred.
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35
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Thiophenols react with the phosphorus center in 8 directly, cosuming the active species prior to 2-position addition.
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Thiophenols react with the phosphorus center in 8 directly, cosuming the active species prior to 2-position addition.
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