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78449306613
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Abbreviations: PyBroP = bromo-tris-pyrrolidino-phosphonium hexafluorophosphate; BroP = bromo-tris-dimethylamino-phosphonium hexafluorophosphate; PyBOP = benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate; BOP = benzotriazole-1-yl-oxy-tris-dimethylamino- phosphonium hexafluorophosphate
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Abbreviations: PyBroP = bromo-tris-pyrrolidino-phosphonium hexafluorophosphate; BroP = bromo-tris-dimethylamino-phosphonium hexafluorophosphate; PyBOP = benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate; BOP = benzotriazole-1-yl-oxy-tris-dimethylamino- phosphonium hexafluorophosphate.
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17
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37549031766
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Keiko Tabei, K.5
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78449283804
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For entry 6, as anticipated, no racemization and no protecting-group degredation occurred. Chiral purity was determined on a Chiralpak AD Column, 5% IPO/heptanes with 0.1% DEA, 210 nm, 1 mL/min flow rate, and compared to a racemic standard
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For entry 6, as anticipated, no racemization and no protecting-group degredation occurred. Chiral purity was determined on a Chiralpak AD Column, 5% IPO/heptanes with 0.1% DEA, 210 nm, 1 mL/min flow rate, and compared to a racemic standard.
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78449293005
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Examples of 1-position regioselectivity with isoquinoline- N -oxides are known
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Examples of 1-position regioselectivity with isoquinoline- N -oxides are known
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25
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2542507637
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Ferrer, M.; Sanchez-Baeza, F.; Messeguer, A. Tetrahedron 1997, 53, 15877-15888
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Ferrer, M.1
Sanchez-Baeza, F.2
Messeguer, A.3
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26
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78449303969
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For a review on the regioselectivity of nucleophilic addition onto activated pyridines see
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For a review on the regioselectivity of nucleophilic addition onto activated pyridines see
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28
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78449277839
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Hard-hard/soft-soft interactions during the nucleophilic addition transition state are proposed to influence regioselectivity in addition to activated pyridines and may work in concert with the proposed charge interaction
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Hard-hard/soft-soft interactions during the nucleophilic addition transition state are proposed to influence regioselectivity in addition to activated pyridines and may work in concert with the proposed charge interaction.
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