Probiotics and the immunological response to infant vaccinations: A prospective, placebo controlled pilot study

Archives of Disease in Childhood

Volumn 96, Issue 4, 2011, Pages 345-349

  Youngster, Ilan ^a   Kozer, Eran ^a   Lazarovitch, Zipora ^a   Broide, Efrat ^a   Goldman, Michael ^a  

^a ASSAF HAROFEH MEDICAL CENTER   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

CHICKENPOX MEASLES MUMPS RUBELLA VACCINE; DIPHTHERIA TETANUS VACCINE; HAEMOPHILUS INFLUENZAE TYPE B VACCINE; IMMUNOGLOBULIN G; PLACEBO; POLIOMYELITIS VACCINE; PRIORIX TETRA; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

ANTIBODY TITER; ARTICLE; CHICKENPOX; CONTROLLED STUDY; DIARRHEA; DIPHTHERIA; DOUBLE BLIND PROCEDURE; DRUG FEVER; FEMALE; HUMAN; IMMUNE RESPONSE; INFANT; INFLUENZA B; MAJOR CLINICAL STUDY; MALE; MEASLES; MUMPS; POLIOMYELITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESTLESSNESS; RUBELLA; SUPPLEMENTATION; TETANUS; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; VACCINATION;

ANTIBODIES, VIRAL; CHICKENPOX VACCINE; EPIDEMIOLOGIC METHODS; FEMALE; HUMANS; IMMUNIZATION SCHEDULE; IMMUNOGLOBULIN G; INFANT; MALE; MEASLES-MUMPS-RUBELLA VACCINE; PROBIOTICS;

EID: 79953200425     PISSN: 00039888     EISSN: 14682044     Source Type: Journal    
DOI: 10.1136/adc.2010.197459     Document Type: Article

References (30)

1. Arbeter AM, Starr SE, Plotkin SA. Varicella vaccine studies in healthy children and adults. Pediatrics 1986;78:748-56. (Pubitemid 16007078)
2. Kilter BJ, Weibel RE, Guess HA, et al. Oka/Merck varicella vaccine in healthy children: final report of a 2-year efficacy study and 7-year follow-up studies. Vaccine 1991;9:643-7.
3. Schrezenmeir J, de Vrese M. Probiotics, prebiotics, and synbiotics - approaching a definition. Am J Clin Nutr 2001;73:361-4S.
4. de Vrese M, Schrezenmeir J. Probiotics, prebiotics, and synbiotics. Adv Biochem Eng Biotechnol 2008;111:1-66.
5. Gill H, Prasad J. Probiotics, immunomodulation,and health benefits. Adv Exp Med Biol 2008;606:423-54.
6. Gill HS, Rutherfurd KJ, Prasad J, et al. Enhancement of natural and acquired immunity by Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019). Br J Nutr 2000;83:167-76. (Pubitemid 30093049)
7. Gill HS, Cross ML, Rutherfurd KJ, et al. Dietary probiotic supplementation to enhance cellular immunity in the elderly. Br J Biomed Sci 2001;58:94-6. (Pubitemid 32566038)
8. Haghighi HR, Gong J, Gyles CL, et al. Probiotics stimulate production of natural antibodies in chickens. Clin Vaccine Immunol 2006;13:975-80. (Pubitemid 44518964)
9. Mohamadzadeh M, Olson S, Kalina WV, et al. Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc Natl Acad Sci USA 2005;102:2880-5. (Pubitemid 40299885)
10. Mohamadzadeh M, Klaenhammer TR. Specific Lactobacillus species differentially activate Toll-like receptors and downstream signals in dendritic cells. Expert Rev Vaccines 2008;7:1155-64.
11. Paineau D, Carcano D, Leyer G, et al. Effects of seven potential probiotic strains on specific immune responses in healthy adults: a double-blind, randomized, controlled trial. FEMS Immunol Med Microbiol 2008;53:107-13. (Pubitemid 351659718)
12. Schierack P, Wieler LH, Taras D, et al. Bacillus cereus var. toyoi enhanced systemic immune response in piglets. Vet Immunol Immunopathol 2007;118:1-11. (Pubitemid 46970787)
13. Sheih YH, Chiang BL, Wang LH, et al. Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. J Am Coll Nutr 2001;20:149-56.
14. Klein A, Friedrich U, Vogelsang H, et al. Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp lactis DGCC 420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr 2008;62:584-93. (Pubitemid 351663397)
15. Boge T, Rémigy M, Vaudaine S, et al. A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine 2009;27:5677-84.
16. Bunout D, Hirsch S, Pía de la Maza M, et al. Effects of prebiotics on the immune response to vaccination in the elderly. JPEN J Parenter Enteral Nutr 2002;26:372-6. (Pubitemid 35216930)
17. de Vrese M, Winkler P, Rautenberg P, et al. Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. Vaccine 2006;24:6670-4. (Pubitemid 46107165)
18. Maeda N, Nakamura R, Hirose Y, et al. Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice. Int Immunopharmacol 2009;9:1122-5.
19. Soh SE, Ong DQ, Gerez I, et al. Effect of probiotic supplementation in the first 6 months of life on specific antibody responses to infant Hepatitis B vaccination. Vaccine 2010;28:2577-9.
20. Taylor AL, Hale J, Wiltschut J, et al. Effects of probiotic supplementation for the first 6 months of life on allergen- and vaccine-specific immune responses. Clin Exp Allergy 2006;36:1227-35. (Pubitemid 44498228)
21. West CE, Gothefors L, Granström M, et al. Effects of feeding probiotics during weaning on infections and antibody responses to diphtheria, tetanus and Hib vaccines. Pediatr Allergy Immunol 2008;19:53-60.
22. Ercan TE, Soycan LY, Apak H, et al. Antibody titers and immune response to diphtheria-tetanus-pertussis and measles-mumps-rubella vaccination in children treated for acute lymphoblastic leukemia. J Pediatr Hematol Oncol 2005;27:273-7. (Pubitemid 40705809)
23. Pérez N, Iannicelli JC, Girard-Bosch C, et al. Effect of probiotic supplementation on immunoglobulins, isoagglutinins and antibody response in children of low socio-economic status. Eur J Nutr 2010;49:173-9.
24. Mastrangeli G, Corinti S, Butteroni C, et al. Effects of live and inactivated VSL#3 probiotic preparations in the modulation of in vitro and in vivo allergen-induced Th2 responses. Int Arch Allergy Immunol 2009;150:133-43.
25. Prymula R, Siegrist CA, Chlibek R, et al. Effect of prophylactic paracetamol administration at time of vaccination on febrile reactions and antibody responses in children: two open-label, randomised controlled trials. Lancet 2009;374:1339-50.
26. Gibson RA, Barclay D, Marshall H, et al. Safety of supplementing infant formula with long-chain polyunsaturated fatty acids and Bifidobacterium lactis in term infants: a randomised controlled trial. Br J Nutr 2009;101:1706-13.
27. Kalliomäki M, Salminen S, Arvilommi H, et al. Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 2001;357:1076-9. (Pubitemid 32322538)
28. Kalliomäki M, Salminen S, Poussa T, et al. Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 2003;361:1869-71. (Pubitemid 36645184)
29. Rosenfeldt V, Benfeldt E, Nielsen SD, et al. Effect of probiotic Lactobacillus strains in children with atopic dermatitis. J Allergy Clin Immunol 2003;111:389-95. (Pubitemid 36228562)
30. Canani RB, Cirillo P, Terrin G, et al. Probiotics for treatment of acute diarrhoea in children: randomised clinical trial of five different preparations. BMJ 2007;335:340.