A seven-year survey of management of coagulase-negative staphylococcal sepsis in the neonatal intensive care unit: Vancomycin may not be necessary as empiric therapy

Neonatology

Volumn 100, Issue 2, 2011, Pages 180-185

  Hemels, Marieke A C ^a   Van Den Hoogen, Agnes ^a   Verboon Maciolek, Malgorzata A ^a   Fleer, André ^a,b   Krediet, Tannette G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Cephalosporins; Neonatal infections; Staphylococci; Vancomycin

Indexed keywords

CEFAZOLIN; GENTAMICIN; OXACILLIN; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTERIUM ISOLATE; CATHETER REMOVAL; CENTRAL VENOUS CATHETER; COAGULASE NEGATIVE STAPHYLOCOCCUS; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EPSILOMETER TEST; FEMALE; HUMAN; INDWELLING CATHETER; INFANT; MAJOR CLINICAL STUDY; MALE; MINIMUM INHIBITORY CONCENTRATION; NEWBORN INTENSIVE CARE; NONHUMAN; PRIORITY JOURNAL; RETROSPECTIVE STUDY; REVIEW; STAPHYLOCOCCAL BACTEREMIA; SYMPTOM; TREATMENT OUTCOME; TREATMENT RESPONSE;

ANTI-BACTERIAL AGENTS; CEFAZOLIN; COAGULASE; FEMALE; HUMANS; INFANT, NEWBORN; INTENSIVE CARE UNITS, NEONATAL; LONGITUDINAL STUDIES; MALE; RETROSPECTIVE STUDIES; SEPSIS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS; TREATMENT OUTCOME; VANCOMYCIN;

STAPHYLOCOCCUS;

EID: 79953198658     PISSN: 16617800     EISSN: 16617819     Source Type: Journal    
DOI: 10.1159/000324852     Document Type: Review

References (29)

1. Stoll BJ, Hansen N: Infections in VLBW infants: Studies from the NICHD Neonatal Research Network. Semin Perinatol 2003; 27: 293-301. (Pubitemid 37099810)
2. Curtis C, Shetty N: Recent trends and prevention of infection in the neonatal intensive care unit. Curr Opin Infect Dis 2008; 21: 350-356.
3. Stoll BJ, Hansen N, Fanaroff AA, Wright LL, Carlo WA, Ehrenkranz RA, Lemons JA, Donovan EF, Stark AR, Tyson JE, Oh W, Bauer CR, Korones SB, Shankaran S, Laptook AR, Stevenson DK, Papile LA, Poole WK: Late-onset sepsis in very low birth weight neonates: The experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110: 285-291. (Pubitemid 34833012)
4. Van den Hoogen A, Gerards LJ, Verboon- Maciolek MA, Fleer A, Krediet TG: Longterm trends in the epidemiology of neonatal sepsis and antibiotic susceptibility of causative agents. Neonatology 2010; 97: 22-28.
5. Karlowicz MG, Buescher ES, Surka AE: Fulminant late-onset sepsis in a neonatal intensive care unit, 1988-1997, and the impact of avoiding empiric vancomycin therapy. Pediatrics 2000; 106: 1387-1390.
6. Makhoul IR, Sujov P, Smolkin T, Lusky A, Reichman B: Pathogen-specific early mortality in very low birth weight infants with late-onset sepsis: A national survey. Clin Infect Dis 2005; 40: 218-224. (Pubitemid 40110664)
7. Orscheln RC, Shinefield HR, St Geme JW: Staphylococcal infections; in Remington JS, Klein JO (eds): Infectious Diseases of the Fetus and Newborn Infant. Philadelphia, Elsevier Saunders, 2006, p 532.
8. Tornieporth NG, Roberts RB, John J, Hafner A, Riley LW: Risk factors associated with vancomycin-resistant Enterococcus faecium infection or colonization in 145 matched case patients and control patients. Clin Infect Dis 1996; 23: 767-772. (Pubitemid 26331122)
9. McNeeley DF, Brown AE, Noel GJ, Chung M, De Lencastre H: An investigation of vancomycin- resistant Enterococcus faecium within the pediatric service of a large urban medical center. Pediatr Infect Dis J 1998; 17: 184-188. (Pubitemid 28146057)
10. Fridkin SK: Vancomycin-intermediate and -resistant Staphylococcus aureus : What the infectious disease specialist needs to know. Clin Infect Dis 2001; 32: 108-115. (Pubitemid 32150955)
11. Krediet TG, Jones ME, Gerards LJ, Fleer A: Clinical outcome of cephalothin versus vancomycin therapy in the treatment of coagulase- negative staphylococcal septicemia in neonates: Relation to methicillin resistance and mec A gene carriage of blood isolates. Pediatrics 1999; 103:e29.
12. Palazzi DL, Klein JO, Baker CJ: Bacterial sepsis and meningitis; in Remington JS, Klein JO (eds): Infectious Diseases of the Fetus and Newborn Infant. Philadelphia, Elsevier Saunders, 2006, pp 247-295.
13. Isaacs D: Australasian Study Group for Neonatal Infections: A 10-year, multicentre study of coagulase-negative staphylococcal infections in Australasian neonatal units. Arch Dis Child Fetal Neonatal Ed 2003; 88:F89-F93. (Pubitemid 36269526)
14. Ngui-Yen JH, Bryce EA, Porter C, Smith JA: Evaluation of the E test by using selected Gram-positive bacteria. J Clin Microbial 1992; 30: 2150-2152.
15. Van den Hoogen A, Brouwer MJ, Gerards LJ, Fleer A, Krediet TG: Removal of percutaneously inserted central venous catheters in neonates is associated with the occurrence of sepsis. Acta Paediatr 2008; 97: 1250-1252.
16. Cairns PA, Wilson DC, McClure BG, Halliday HL, McReid M: Percutaneous central venous catheter use in the very low birth weight neonate. Eur J Pediatr 1995; 154: 145-147.
17. Benjamin DK Jr, Miller W, Garges H, Benjamin DK, McKinney RE Jr, Cotton M, Fisher RG, Alexander KA: Bacteremia, central catheters, and neonates: When to pull the line. Pediatrics 2001; 107: 1272-1276. (Pubitemid 32525201)
18. Mermel LA, Allon M, Bouza E, Craven DE, Flynn P, O'Grady NP, Raad II, Rijnders BJ, Sherertz RJ, Warren DK: Clinical practice guidelines for the diagnosis and management of intravascular catheter-related infection: 2009 Update by the Infectious Diseases Society of America. Clin Infect Dis 2009; 49: 1-45.
19. Flynn PM: Diagnosis and management of central venous catheter-related bloodstream infections in pediatric patients. Pediatr Infect Dis J 2009; 28: 1016-1017.
20. Krediet TG, Beurskens FJ, van Dijk H, Gerards LJ, Fleer A: Antibody responses and opsonic activity in sera of preterm neonates with coagulase-negative staphylococcal septicemia and the effect of the administration of fresh frozen plasma. Pediatr Res 1998; 43: 645-651. (Pubitemid 28196457)
21. Guignard B, Entenza JM, Moreillon P: Betalactams against methicillin-resistant Staphylococcus aureus. Curr Opin Pharmacol 2005; 5: 479-489. (Pubitemid 41258564)
22. Lim D, Strynadka NC: Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus Nat Struct Biol 2002; 9: 870-876. (Pubitemid 35257789)
23. Kollef MH: Limitations of vancomycin in the management of resistant staphylococcal infections. Clin Infect Dis 2007; 45:S191-S195. (Pubitemid 47378906)
24. Chua K, Howden BP: Treating Gram-positive infections: Vancomycin update and the whys, wherefores and evidence base for continuous infusion of anti-Gram-positive antibiotics. Curr Opin Infect Dis 2009; 22: 525-534.
25. Dehority W: Use of vancomycin in pediatrics. Pediatr Infect Dis J 2010; 29: 462-464.
26. Anderson-Berry A, Brinton B, Lyden E, Faix RG: Risk factors associated with development of persistent coagulase-negative staphylococci bacteremia in the neonate and associated short-term and discharge morbidities. Neonatology 2011; 99: 23-31.
27. Horan TC, Andrus M, Dudeck, MA: CDC/ NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008; 36: 309-332. (Pubitemid 351763841)
28. Powers RJ, Wirtschafter DW: Decreasing central line associated bloodstream infection in neonatal intensive care. Clin Perinatol 2010; 37: 247-272.
29. Guerti K, Ieven M, Mahieu L: Diagnosis of catheter-related bloodstream infection in neonates: A study on the value of differential time to positivity of paired blood cultures. Pediatr Crit Care Med 2007; 8: 470-475. (Pubitemid 47415301)