메뉴 건너뛰기




Volumn 63, Issue 1, 2011, Pages 157-164

Induction of P450 3A1/2 and 2C6 by gemfibrozil in Sprague-Dawley rats

Author keywords

Gemfibrozil; Induction; P450; Rat

Indexed keywords

ALPHA HYDROXYMIDAZOLAM; BEZAFIBRATE; CYTOCHROME P450 2C; CYTOCHROME P450 2C6; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; DEXTROMETHORPHAN; DEXTRORPHAN; DICLOFENAC; FLUFENAMIC ACID; GEMFIBROZIL; PROPRANOLOL; TRIAZOLAM; UNCLASSIFIED DRUG;

EID: 79953194857     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(11)70410-8     Document Type: Article
Times cited : (11)

References (25)
  • 3
    • 0042858402 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor α induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme
    • DOI 10.1074/jbc.M305361200
    • Barbier O, Duran-Sandoval D, Pineda-Torra I, Kosykh V, Fruchart JC, Staels B: Peroxisome proliferator-activated receptor α induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme. J Biol Chem, 2003, 278, 32852-32860. (Pubitemid 37055727)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.35 , pp. 32852-32860
    • Barbier, O.1    Duran-Sandoval, D.2    Pineda-Torra, I.3    Kosykh, V.4    Fruchart, J.-C.5    Staels, B.6
  • 8
    • 33645800801 scopus 로고    scopus 로고
    • Fibrates in combination with statins in the management of dyslipidemia
    • Greenwich, quiz 42-43
    • Jacobson TA, Zimmerman FH: Fibrates in combination with statins in the management of dyslipidemia. J Clin Hypertens (Greenwich), 2006, 8, 35-41; quiz 42-43.
    • (2006) J Clin Hypertens , vol.8 , pp. 35-41
    • Jacobson, T.A.1    Zimmerman, F.H.2
  • 10
    • 0036497073 scopus 로고    scopus 로고
    • Substrate specificity for rat cytochrome P450 (CYP) isoforms: Screening with cDNA-expressed systems of the rat
    • DOI 10.1016/S0006-2952(01)00843-7, PII S0006295201008437
    • Kobayashi K, Urashima K, Shimada N, Chiba K: Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat. Biochem Pharmacol, 2002, 63, 889-896. (Pubitemid 34243002)
    • (2002) Biochemical Pharmacology , vol.63 , Issue.5 , pp. 889-896
    • Kobayashi, K.1    Urashima, K.2    Shimada, N.3    Chiba, K.4
  • 11
    • 76049108649 scopus 로고    scopus 로고
    • Effect of atorvastatin and fenofibric acid on adipokine release from visceral and subcutaneous adipose tissue of patients with mixed dyslipidemia and normolipidemic subjects
    • Krysiak R, Łabuzek K, Okopień B: Effect of atorvastatin and fenofibric acid on adipokine release from visceral and subcutaneous adipose tissue of patients with mixed dyslipidemia and normolipidemic subjects. Pharmacol Rep, 2009, 61, 1134-1145.
    • (2009) Pharmacol Rep , vol.61 , pp. 1134-1145
    • Krysiak, R.1    Łabuzek, K.2    Okopień, B.3
  • 12
    • 77950855915 scopus 로고    scopus 로고
    • Metabolic and monocyte-suppressing actions of fenofibrate in patients with mixed dyslipidemia and early glucose metabolism disturbances
    • Krysiak R, Stachura-Kułach A, Okopień B: Metabolic and monocyte-suppressing actions of fenofibrate in patients with mixed dyslipidemia and early glucose metabolism disturbances. Pharmacol Rep, 2010, 62, 120-130.
    • (2010) Pharmacol Rep , vol.62 , pp. 120-130
    • Krysiak, R.1    Stachura-Kułach, A.2    Okopień, B.3
  • 13
    • 0037534010 scopus 로고    scopus 로고
    • Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance
    • DOI 10.1016/S0009-9236(03)00052-3
    • Kyrklund C, Backman JT, Neuvonen M, Neuvonen PJ: Gemfibrozil increases plasma pravastatin concentrations and reduces pravastatin renal clearance. Clin Pharmacol Ther, 2003, 73, 538-544. (Pubitemid 37249124)
    • (2003) Clinical Pharmacology and Therapeutics , vol.73 , Issue.6 , pp. 538-544
    • Kyrklund, C.1    Backman, J.T.2    Neuvonen, M.3    Neuvonen, P.J.4
  • 14
    • 60749134645 scopus 로고    scopus 로고
    • Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties
    • Liu A, Xie S, Sun H, Gonzalez FJ, Wei X, Dai R: Myotoxicity of gemfibrozil in cynomolgus monkey model and its relationship to pharmacokinetic properties. Toxicol Appl Pharmacol, 2009, 235, 287-295.
    • (2009) Toxicol Appl Pharmacol , vol.235 , pp. 287-295
    • Liu, A.1    Xie, S.2    Sun, H.3    Gonzalez, F.J.4    Wei, X.5    Dai, R.6
  • 15
    • 70749135180 scopus 로고    scopus 로고
    • An inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats
    • Mei L, Zhang L, Dai R: An inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats. J Enzyme Inhib Med Chem, 2009, 24, 753-762.
    • (2009) J Enzyme Inhib Med Chem , vol.24 , pp. 753-762
    • Mei, L.1    Zhang, L.2    Dai, R.3
  • 16
    • 29944446317 scopus 로고    scopus 로고
    • Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: Implications for drug-drug interactions
    • DOI 10.1124/dmd.105.007633
    • Ogilvie BW, Zhang D, Li W, Rodrigues AD, Gipson AE, Holsapple J, Toren P, Parkinson A: Glucuronidation converts gemfibrozil to a potent, metabolism-dependent inhibitor of CYP2C8: implications for drug-drug interactions. Drug Metab Dispos, 2006, 34, 191-197. (Pubitemid 43042661)
    • (2006) Drug Metabolism and Disposition , vol.34 , Issue.1 , pp. 191-197
    • Ogilvie, B.W.1    Zhang, D.2    Li, W.3    Rodrigues, A.D.4    Gipson, A.E.5    Holsapple, J.6    Toren, P.7    Parkinson, A.8
  • 17
    • 60749122461 scopus 로고    scopus 로고
    • Biological pathways and plasma biomarkers for muscle toxicity induced by a PPARα agonist, fenofibrate
    • Plasterer T, Hamano T, Damian D, Okada M, Jahasz P, Shimizu T, Zeng C et al.: Biological pathways and plasma biomarkers for muscle toxicity induced by a PPARα agonist, fenofibrate. Toxicol Lett, 2007, 172, 1, S54.
    • (2007) Toxicol Lett , vol.172 , Issue.1
    • Plasterer, T.1    Hamano, T.2    Damian, D.3    Okada, M.4    Jahasz, P.5    Shimizu, T.6    Zeng, C.7
  • 21
    • 4644301418 scopus 로고    scopus 로고
    • Gemfibrozil and its glucoronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)-mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: Analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil
    • DOI 10.1124/jpet.104.068536
    • Shitara Y, Hirano M, Sato H, Sugiyama Y: Gemfibrozil and its glucuronide inhibit the organic anion transporting polypeptide 2 (OATP2/OATP1B1:SLC21A6)- mediated hepatic uptake and CYP2C8-mediated metabolism of cerivastatin: analysis of the mechanism of the clinically relevant drug-drug interaction between cerivastatin and gemfibrozil. J Pharmacol Exp Ther, 2004, 311, 228-236. (Pubitemid 39287802)
    • (2004) Journal of Pharmacology and Experimental Therapeutics , vol.311 , Issue.1 , pp. 228-236
    • Shitara, Y.1    Hirano, M.2    Sato, H.3    Sugiyama, Y.4
  • 22
    • 0037310871 scopus 로고    scopus 로고
    • Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A
    • DOI 10.1124/jpet.102.041921
    • Shitara Y, Itoh T, Sato H, Li AP, Sugiyama Y: Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A. J Pharmacol Exp Ther, 2003, 304, 610-616. (Pubitemid 36152336)
    • (2003) Journal of Pharmacology and Experimental Therapeutics , vol.304 , Issue.2 , pp. 610-616
    • Shitara, Y.1    Itoh, T.2    Sato, H.3    Li, A.P.4    Sugiyama, Y.5
  • 23
    • 0037075262 scopus 로고    scopus 로고
    • Cerivastatin and reports of fatal rhabdomyolysis
    • Staffa JA, Chang J, Green L: Cerivastatin and reports of fatal rhabdomyolysis. N Engl J Med, 2002, 346, 539-540.
    • (2002) N Engl J Med , vol.346 , pp. 539-540
    • Staffa, J.A.1    Chang, J.2    Green, L.3
  • 24
    • 34047252007 scopus 로고    scopus 로고
    • Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis
    • DOI 10.1016/j.jpba.2007.02.034, PII S0731708507001471
    • Yao M, Zhu M, Sinz MW, Zhang H, Humphreys WG, Rodrigues AD, Dai R: Development and full validation of six inhibition assays for five major cytochrome P450 enzymes in human liver microsomes using an automated 96-well microplate incubation format and LC-MS/MS analysis. J Pharm Biomed Anal, 2007, 44, 211-223. (Pubitemid 46551606)
    • (2007) Journal of Pharmaceutical and Biomedical Analysis , vol.44 , Issue.1 , pp. 211-223
    • Yao, M.1    Zhu, M.2    Sinz, M.W.3    Zhang, H.4    Humphreys, W.G.5    Rodrigues, A.D.6    Dai, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.