Gene expression profiles in aldosterone-producing adenomas and adjacent adrenal glands

European Journal of Endocrinology

Volumn 164, Issue 4, 2011, Pages 613-619

  Wang, Tao ^a,b   Satoh, Fumitoshi ^c   Morimoto, Ryo ^c   Nakamura, Yasuhiro ^c   Sasano, Hironobu ^c   Auchus, Richard J ^d   Edwards, Michael A ^a   Rainey, William E ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^c TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; ALDOSTERONE SYNTHASE; CALMODULIN BINDING PROTEIN; CYTOCHROME B5; CYTOCHROME P450 17; TESTOSTERONE 17BETA DEHYDROGENASE; TRANSCRIPTOME;

ADENOMA; ADRENAL GLAND; ADULT; AGED; AKR1C3 GENE; ALDH1A2 GENE; ALDOSTERONE PRODUCING ADENOMA; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYB5 GENE; CYP11B2 GENE; FEMALE; GENE EXPRESSION PROFILING; GENE FUNCTION; HORMONE DETERMINATION; HORMONE SYNTHESIS; HUMAN; MALE; MICROARRAY ANALYSIS; ONCOGENE; PATHOPHYSIOLOGY; PCP4 GENE; PHENOTYPE; PRIORITY JOURNAL; PRRX1 GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; UPREGULATION; VPREB3 GENE; 17ALPHA HYDROXYLASE 17,20 LYASE GENE; 17BETA HYDROXYSTEROID DEHYDROGENASE TYPE 5 GENE; ADRENAL CORTEX ADENOMA; ADRENAL MEDULLA; ALDOSTERONE RELEASE; ALDOSTERONE SYNTHASE GENE; CALMODULIN BINDING PROTEIN GENE; CYTOCHROME B5 GENE; GENE; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENETIC ASSOCIATION; HUMAN TISSUE; MOLECULAR DYNAMICS; PHENOTYPIC VARIATION; PRIMARY HYPERALDOSTERONISM; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STEROIDOGENESIS; TRANSCRIPTION INITIATION;

3-HYDROXYSTEROID DEHYDROGENASES; ADENOMA; ADRENAL GLANDS; ADULT; AGED; ALDOSTERONE; ALDOSTERONE SYNTHASE; FEMALE; GENE EXPRESSION PROFILING; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROID 17-ALPHA-HYDROXYLASE;

EID: 79953185776     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-10-1085     Document Type: Article

References (36)

1. Rossi GP, Bernini G, Caliumi C, Desideri G, Fabris B, Ferri C, Ganzaroli C, Giacchetti G, Letizia C, Maccario M, Mallamaci F, Mannelli M, Mattarello MJ, Moretti A, Palumbo G, Parenti G, Porteri E, Semplicini A, Rizzoni D, Rossi E, Boscaro M, Pessina AC & Mantero F. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. Journal of the American College of Cardiology 2006 48 2293-2300. (doi:10.1016/j.jacc.2006.07.059)
2. Gordon RD. Primary aldosteronism - actual epidemics or false alarm? Arquivos Brasileiros de Endocrinologia e Metabologia 2004 48 666-673. (doi:10.1590/S0004-27302004000500012)
3. Heymes C, Garnier A, Fuchs S, Bendall JK, Nehme J, Ambroisine ML, Robidel E, Swynghedauw B, Milliez P & Delcayre C. Aldosterone-synthase overexpression in heart: a tool to explore aldosterone's effects. Molecular and Cellular Endocrinology 2004 217 213-219. (doi:10.1016/j.mce.2003.10.022)
4. Rossi GP, Bernini G, Desideri G, Fabris B, Ferri C, Giacchetti G, Letizia C, Maccario M, Mannelli M, Matterello MJ, Montemurro D, Palumbo G, Rizzoni D, Rossi E, Pessina AC & Mantero F. Renal damage in primary aldosteronism: results of the PAPY study. Hypertension 2006 48 232-238. (doi:10.1161/01.HYP. 0000230444.01215.6a)
5. Stowasser M. Update in primary aldosteronism. Journal of Clinical Endocrinology and Metabolism 2009 94 3623-3630. (doi:10.1210/jc.2009-1399)
6. Plouin PF, Amar L & Chatellier G. Trends in the prevalence of primary aldosteronism, aldosterone-producing adenomas, and surgically correctable aldosterone-dependent hypertension. Nephrology, Dialysis, Transplantation 2004 19 774-777. (doi:10.1093/ndt/gfh112)
7. Mattsson C & Young WF Jr. Primary aldosteronism: diagnostic and treatment strategies. Nature Clinical Practice. Nephrology 2006 2 198-208 (quiz, 191 p following 230). (doi:10.1038/ncpneph0151)
8. Bassett MH, Mayhew B, Rehman K, White PC, Mantero F, Arnaldi G, Stewart PM, Bujalska I & Rainey WE. Expression profiles for steroidogenic enzymes in adrenocortical disease. Journal of Clinical Endocrinology and Metabolism 2005 90 5446-5455. (doi:10.1210/jc.2005-0836)
9. Connell JM, Fraser R, MacKenzie SM, Friel EC, Ingram MC, Holloway CD & Davies E. The impact of polymorphisms in the gene encoding aldosterone synthase (CYP11B2) on steroid synthesis and blood pressure regulation. Molecular and Cellular Endocrinology 2004 217 243-247. (doi:10.1016/j.mce.2003.10.025)
10. Ye P, Mariniello B, Mantero F, Shibata H & Rainey WE. G-protein-coupled receptors in aldosterone-producing adenomas: a potential cause of hyperaldosteronism. Journal of Endocrinology 2007 195 39-48. (doi:10.1677/JOE-07-0037)
11. Lenzini L, Seccia TM, Aldighieri E, Belloni AS, Bernante P, Giuliani L, Nussdorfer GG, Pessina AC & Rossi GP. Heterogeneity of aldosterone-producing adenomas revealed by a whole transcriptome analysis. Hypertension 2007 50 1106-1113. (doi:10.1161/HYPERTENSIONAHA.107.100438)
12. Saner-Amigh K, Mayhew BA, Mantero F, Schiavi F, White PC, Rao CV & Rainey WE. Elevated expression of luteinizing hormone receptor in aldosterone-producing adenomas. Journal of Clinical Endocrinology and Metabolism 2006 91 1136-1142. (doi:10.1210/jc.2005-1298)
13. Bassett MH,White PC & Rainey WE. The regulation of aldosterone synthase expression. Molecular and Cellular Endocrinology 2004 217 67-74. (doi:10.1016/j.mce.2003.10.011)
14. Holland OB, Carr B & Brasier AR. Aldosterone synthase gene regulation by angiotensin. Endocrine Research 1995 21 455-462. (doi:10.3109/ 07435809509030462)
15. Szekeres M, Turu G, Orient A, Szalai B, Supeki K, Cserzo M, Varnai P & Hunyady L. Mechanisms of angiotensin II-mediated regulation of aldosterone synthase expression in H295R human adrenocortical and rat adrenal glomerulosa cells. Molecular and Cellular Endocrinology 2009 302 244-253. (doi:10.1016/j.mce.2008.12.015)
16. Kempers MJ, Lenders JW, van Outheusden L, van der Wilt GJ, Schultze Kool LJ, Hermus AR & Deinum J. Systematic review: diagnostic procedures to differentiate unilateral from bilateral adrenal abnormality in primary aldosteronism. Annals of Internal Medicine 2009 151 329-337.
17. Giacchetti G, Mulatero P, Mantero F, Veglio F, Boscaro M & Fallo F. Primary aldosteronism, a major form of low renin hypertension: from screening to diagnosis. Trends in Endocrinology and Metabolism 2008 19 104-108. (doi:10.1016/j.tem.2008.01.005)
18. Slater EP, Diehl SM, Langer P, Samans B, Ramaswamy A, Zielke A & Bartsch DK. Analysis by cDNA microarrays of gene expression patterns of human adrenocortical tumors. European Journal of Endocrinology 2006 154 587-598. (doi:10.1530/eje.1.02116)
19. Pezzi V, Mathis JM, Rainey WE & Carr BR. Profiling transcript levels for steroidogenic enzymes in fetal tissues. Journal of Steroid Biochemistry and Molecular Biology 2003 87 181-189. (doi:10.1016/j.jsbmb.2003.07.006)
20. Soon PS, Gill AJ, Benn DE, Clarkson A, Robinson BG, McDonald KL & Sidhu SB. Microarray gene expression and immunohistochemistry analyses of adrenocortical tumors identify IGF2 and Ki-67 as useful in differentiating carcinomas from adenomas. Endocrine-Related Cancer 2009 16 573-583. (doi:10.1677/ERC-08-0237)
21. Suh I, Guerrero MA & Kebebew E. Gene-expression profiling of adrenocortical carcinoma. Expert Review of Molecular Diagnostics 2009 9 343-351. (doi:10.1586/erm.09.13)
22. Tacon LJ, Soon PS, Gill AJ, Chou AS, Clarkson A, Botling J, Stalberg PL, Skogseid BM, Robinson BG, Sidhu SB & Clifton-Bligh RJ. The glucocorticoid receptor is overexpressed in malignant adrenocortical tumors. Journal of Clinical Endocrinology and Metabolism 2009 94 4591-4599. (doi:10.1210/jc.2009- 0546)
23. Johanson RA, Sarau HM, Foley JJ & Slemmon JR. Calmodulin-binding peptide PEP-19 modulates activation of calmodulin kinase II in situ. Journal of Neuroscience 2000 20 2860-2866. (Pubitemid 30220311)
24. Kleerekoper QK & Putkey JA. PEP-19, an intrinsically disordered regulator of calmodulin signaling. Journal of Biological Chemistry 2009 284 7455-7464. (doi:10.1074/jbc.M808067200)
25. Spat A & Hunyady L. Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Physiological Reviews 2004 84 489-539. (doi:10.1152/physrev.00030.2003)
26. Hernandez Perera O, Marrero A & Rodriguez Perez JC. What are the Hox genes? Its importance in vascular and renal disease. Nefrologia 2006 26 195-205.
27. Noda M, Ohno S & Nakajin S. Mono-(2-ethylhexyl) phthalate (MEHP) induces nuclear receptor 4A subfamily in NCI-H295R cells: a possible mechanism of aromatase suppression by MEHP. Molecular and Cellular Endocrinology 2007 274 8-18. (doi:10.1016/j.mce.2007.05.004)
28. Boulkroun S, Samson-Couterie B, Dzib JF, Lefebvre H, Louiset E, Amar L, Plouin PF, Lalli E, Jeunemaitre X, Benecke A, Meatchi T & Zennaro MC. Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism. Hypertension 2010 56 885-892. (doi:10.1161/HYPERTENSIONAHA.110. 158543)
29. Nishimoto K, Nakagawa K, Li D, Kosaka T, Oya M, Mikami S, Shibata H, Itoh H, Mitani F, Yamazaki T, Ogishima T, Suematsu M & Mukai K. Adrenocortical zonation in humans under normal and pathological conditions. Journal of Clinical Endocrinology and Metabolism 2010 95 2296-2305. (doi:10.1210/jc.2009-2010)
30. Arakane F, Sugawara T, Nishino H, Liu Z, Holt JA, Pain D, Stocco DM, Miller WL & Strauss JF III. Steroidogenic acute regulatory protein (StAR) retains activity in the absence of its mitochondrial import sequence: implications for the mechanism of StAR action. PNAS 1996 93 13731-13736. (doi:10.1073/pnas.93.24.13731)
31. Rone MB, Fan J & Papadopoulos V. Cholesterol transport in steroid biosynthesis: role of protein-protein interactions and implications in disease states. Biochimica et Biophysica Acta 2009 1791 646-658. (doi:10.1016/j.bbalip. 2009.03.001)
32. Assie G, Auzan C, Gasc JM, Baviera E, Balaton A, Elalouf JM, Jeunemaitre X, Plouin PF, Corvol P & Clauser E. Steroidogenesis in aldosterone-producing adenoma revisited by transcriptome analysis. Journal of Clinical Endocrinology and Metabolism 2005 90 6638-6649. (doi:10.1210/jc.2005-1309)
33. Lombardi CP, Raffaelli M, Pani G, Maffione A, Princi P, Traini E, Galeotti T, Rossi ED, Fadda G & Bellantone R. Gene expression profiling of adrenal cortical tumors by cDNA macroarray analysis. Results of a preliminary study. Biomedicine and Pharmacotherapy 2006 60 186-190. (doi:10.1016/j.biopha. 2006.03.006)
34. Quackenbush J. Microarray analysis and tumor classification. New England Journal of Medicine 2006 354 2463-2472. (doi:10.1056/NEJMra042342)
35. Giordano TJ, Kuick R, Else T, Gauger PG, Vinco M, Bauersfeld J, Sanders D, Thomas DG, Doherty G & Hammer G. Molecular classification and prognostication of adrenocortical tumors by transcriptome profiling. Clinical Cancer Research 2009 15 668-676. (doi:10.1158/1078-0432.CCR-08-1067)
36. Laurell C, Velazquez-Fernandez D, Lindsten K, Juhlin C, Enberg U, Geli J, Hoog A, Kjellman M, Lundeberg J, Hamberger B, Larsson C, Nilsson P & BackdahlM. Transcriptional profiling enablesmolecular classification of adrenocortical tumours. European Journal of Endocrinology 2009 161 141-152. (doi:10.1530/EJE-09-0068)