Steroidogenesis in aldosterone-producing adenoma revisited by transcriptome analysis

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 12, 2005, Pages 6638-6649

  Assié, Guillaume ^a   Auzan, Colette ^a   Gasc, Jean Marie ^a   Baviera, Erno ^b   Balaton, André ^b   Elalouf, Jean Marc ^c   Jeunemaitre, Xavier ^a   Plouin, Pierre François ^d   Corvol, Pierre ^a   Clauser, Eric ^a  

^a INSERM   (France)

^b SAINT JOSEPH HOSPITAL   (France)

^c CEA SACLAY   (France)

^d HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENODOXIN; ALDOSTERONE; ALDOSTERONE SYNTHASE; ANGIOTENSIN; CHOLESTEROL; CYTOCHROME P450 REDUCTASE; HIGH DENSITY LIPOPROTEIN RECEPTOR; STEROID; STEROID 21 MONOOXYGENASE; TRANSCRIPTOME;

ADENOMA; ADULT; ALDOSTERONE PRODUCING ADENOMA; ANALYTIC METHOD; ARTICLE; CARCINOGENESIS; CIRCULATION; CLINICAL ARTICLE; CONTROLLED STUDY; ELECTRON; FEMALE; GENE EXPRESSION; GENE OVEREXPRESSION; GENOME; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SAMPLING; STEROIDOGENESIS; TISSUE DIFFERENTIATION; UNINDEXED SEQUENCE; ZONA GLOMERULOSA;

EID: 28744439005     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2005-1309     Document Type: Article

References (50)

1. Stowasser M, Gordon RD 2003 Primary aldosteronism: from genesis to genetics. Trends Endocrinol Metab 14:310-317
2. Rocha R, Funder JW 2002 The pathophysiology of aldosterone in the cardiovascular system. Ann NY Acad Sci 970:89-100
3. Sutherland DJ, Ruse JL, Laidlaw JC 1966 Hypertension, increased aldosterone secretion and low plasma renin activity relieved by dexamethasone. Can Med Assoc J 95:1109-1119
4. Lifton RP, Dluhy RG, Powers M, Rich GM, Cook S, Ulick S, Lalouel JM 1992 A chimaeric 11β-hydroxylase/aldosterone synthase gene causes glucocorticoid-remediable aldosteronism and human hypertension. Nature 355:262-265
5. Conn JW, Louis LH 1956 Primary aldosteronism, a new clinical entity. Ann Intern Med 44:1-15
6. Therien B, Mellinger RC, Caldwell JR, Howard PJ 1959 Primary aldosteronism due to adrenal hyperplasia; occurrence in a boy aged 10 years. AMA J Dis Child 98:90-99
7. Suzuki H, Shibata H, Maruyama T, Ishimura Y, Saruta T 1995 Significance of steroidogenic enzymes in the pathogenesis of hyperfunctioning and non-hyperfunctioning adrenal tumor. Steroids 60:42-47
8. Fallo F, Pezzi V, Barzon L, Mulatero P, Veglio F, Sonino N, Mathis JM 2002 Quantitative assessment of CYP11B1 and CYP11B2 expression in aldosterone-producing adenomas. Eur J Endocrinol 147:795-802
9. Wu KD, Chen YM, Chu JS, Hung KY, Hsieh TS, Hsieh BS 1995 Zona fasciculata-like cells determine the response of plasma aldosterone to metoclopramide and aldosterone synthase messenger ribonucleic acid level in aldosterone-producing adenoma. J Clin Endocrinol Metab 80:783-789
10. Bassett MH, White PC, Rainey WE 2004 The regulation of aldosterone synthase expression. Mol Cell Endocrinol 217:67-74
11. Capponi AM 2002 Regulation of cholesterol supply for mineralocorticoid biosynthesis. Trends Endocrinol Metab 13:118-121
12. 2+ influx, and protein kinase C activation in sustained cellular responses. Endocr Rev 16:649-681
13. Velculescu VE, Zhang L, Vogelstein B, Kinzler KW 1995 Serial analysis of gene expression. Science 270:484-487
14. Haning R, Tait SA, Tait JF 1970 In vitro effects of ACTH, angiotensins, serotonin and potassium on steroid output and conversion of corticosterone to aldosterone by isolated adrenal cells. Endocrinology 87:1147-1167
15. Virlon B, Cheval L, Buhler JM, Billon E, Doucet A, Elalouf JM 1999 Serial microanalysis of renal transcriptomes. Proc Natl Acad Sci USA 96:15286-15291
16. Pascoe L, Jeunemaitre X, Lebrethon MC, Curnow KM, Gomez-Sanchez CE, Gasc JM, Saez JM, Corvol P 1995 Glucocorticoid-suppressible hyperaldosteronism and adrenal tumors occurring in a single French pedigree. J Clin Invest 96:2236-2246
17. Sibony M, Commo F, Callard P, Gasc JM 1995 Enhancement of mRNA in situ hybridization signal by microwave heating. Lab Invest 73:586-591
18. Clark BJ, Stocco DM 1997 Steroidogenic acute regulatory protein: the StAR still shines brightly. Mol Cell Endocrinol 134:1-8
19. Enberg U, Farnebo LO, Wedell A, Grondal S, Thoren M, Grimelius L, Kjellman M, Backdahl M, Hamberger B 2001 In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17. World J Surg 25:957-966
20. Bassett MH, Mayhew B, Rehman K, White PC, Mantero F, Amaldi G, Stewart PM, Bujalska I, Rainey WE 2005 Expression profiles for steroidogenic enzymes in adrenocortical disease. J Clin Endocrinol Metab 90:5446-5455
21. Beuschlein F, Schulze E, Mora P, Gensheimer HP, Maser-Gluth C, Allolio B, Reincke M 1998 Steroid 21-hydroxylase mutations and 21-hydroxylase messenger ribonucleic acid expression in human adrenocortical tumors. J Clin Endocrinol Metab 83:2585-2588
22. Ogo A, Haji M, Ohashi M, Nawata H 1991 Expression of cytochrome P-450 mRNAs in steroidogenesis of adrenocortical adenomas from patients with primary aldosteronism. Mol Cell Endocrinol 76:7-12
23. Vinson GP 2004 Glomerulosa function and aldosterone synthesis in the rat. Mol Cell Endocrinol 217:59-65
24. Chu MD, Ulick S 1982 Isolation and identification of 18-hydroxycortisol from the urine of patients with primary aldosteronism. J Biol Chem 257:2218-2224
25. Reincke M, Beuschlein F, Lalli E, Arlt W, Vay S, Sassone-Corsi P, Allolio B 1998 DAX-1 expression in human adrenocortical neoplasms: implications for steroidogenesis. J Clin Endocrinol Metab 83:2597-2600
26. Zenkert S, Schubert B, Fassnacht M, Beuschlein F, Allolio B, Reincke M 2000 Steroidogenic acute regulatory protein mRNA expression in adrenal tumours. Eur J Endocrinol 142:294-299
27. + in H295R adrenocortical cells. Mol Cell Endocrinol 115:215-219
28. Cherradi N, Rossier MF, Vallotton MB, Timberg R, Friedberg I, Orly J, Wang XJ, Stocco DM, Capponi AM 1997 Submitochondrial distribution of three key steroidogenic proteins (steroidogenic acute regulatory protein and cytochrome p450scc and 3β-hydroxysteroid dehydrogenase isomerase enzymes) upon stimulation by intracellular calcium in adrenal glomerulosa cells. J Biol Chem 272:7899-7907
29. Cao PR, Bernhardt R 1999 Modulation of aldosterone biosynthesis by adrenodoxin mutants with different electron transport efficiencies. Eur J Biochem 265:152-159
30. Bernhardt R 1996 Cytochrome P450: structure, function, and generation of reactive oxygen species. Rev Physiol Biochem Pharmacol 127:137-221
31. Fluck CE, Tajima T, Pandey AV, Arlt W, Okuhara K, Verge CF, Jabs EW, Mendonca BB, Fujieda K, Miller WL 2004 Mutant P450 oxidoreductase causes disordered steroidogenesis with and without Antley-Bixler syndrome. Nat Genet 36:228-230
32. Hall PF, Osawa S, Thomasson CL 1981 A role for calmodulin in the regulation of steroidogenesis. J Cell Biol 90:402-407
33. +-mediated aldosterone secretion: lesser role of protein kinase C. Biochem Biophys Res Commun 182:254-261
34. Balla T, Spat A 1982 The effect of various calmodulin inhibitors on the response of adrenal glomerulosa cells to angiotensin II and cyclic AMP. Biochem Pharmacol 31:3705-3707
35. Wilson JX, Aguilera G, Catt KJ 1984 Inhibitory actions of calmodulin antagonists on steroidogenesis in zona glomerulosa cells. Endocrinology 115:1357-1363
36. Cook MD, Phillips MI, Cook VI, Kimura B, Wilcox CS 1993 Angiotensin II receptor subtypes on adrenal adenoma in primary hyperaldosteronism. J Am Soc Nephrol 4:111-116
37. Nawata H, Takayanagi R, Ohnaka K, Sakai Y, Imasaki K, Tanase T, Ikuyama S, Tanaka S, Ohe K 1995 Type 1 angiotensin II receptors of adrenal tumors. Steroids 60:28-34
38. Schubert B, Fassnacht M, Beuschlein F, Zenkert S, Allolio B, Reincke M 2001 Angiotensin II type 1 receptor and ACTH receptor expression in human adrenocortical neoplasms. Clin Endocrinol (Oxf) 54:627-632
39. Imai T, Hirata Y, Eguchi S, Kanno K, Akiba T, Sakamoto A, Yanagisawa M, Masaki T, Marumo F 1992 Concomitant expression of receptor subtype and isopeptide of endothelin by human adrenal gland. Biochem Biophys Res Commun 182:1115-1121
40. Rossi G, Albertin G, Belloni A, Zanin L, Biasolo MA, Prayer-Galetti T, Bader M, Nussdorfer GG, Palu G, Persina AC 1994 Gene expression, localization, and characterization of endothelin A and B receptors in the human adrenal cortex. J Clin Invest 94:1226-1234
41. Zeng Z, Tang X, Yang D, Zeng Z, Tang X, Yang D, Li H, Zhang R, Zeng O, Li M, Chen J, Lu Z, Demura H, Narrise M, Shi Y 1998 Immunoreactive endothelin-1 and its receptors in human adrenal tissues. J Cardiovasc Pharmacol 31(Suppl 1):S212-S214
42. Douglas JG, Brown GP, White C 1984 Angiotensin II receptors of human and primate adrenal fasciculata and glomerulosa: correlations of binding and steroidogenesis. Metabolism 33:685-688
43. 2+-regulated expression of aldosterone synthase is mediated by calmodulin and calmodulin-dependent protein kinases. Endocrinology 138:835-838
44. Condon JC, Pezzi V, Drummond BM, Yin S, Rainey WE 2002 Calmodulin-dependent kinase I regulates adrenal cell expression of aldosterone synthase. Endocrinology 143:3651-3657
45. 2+-regulated expression of 21-hydroxylase cytochrome P450 in H295R human adrenocortical cells. J Clin Endocrinol Metab 83:1592-1597
46. Cherradi N, Bideau M, Arnaudeau S, Demaurex N, James RW, Azhar S, Capponi AM 2001 Angiotensin II promotes selective uptake of high density lipoprotein cholesterol esters in bovine adrenal glomerulosa and human adrenocortical carcinoma cells through induction of scavenger receptor class B type I. Endocrinology 142:4540-4549
47. Kem DC, Weinberger MH, Higgins JR, Kramer NJ, Gomez-Sanchez C, Holland OB 1978 Plasma aldosterone response to ACTH in primary aldosteronism and in patients with low renin hypertension. J Clin Endocrinol Metab 46:552-560
48. Mancini T, Kola B, Mantero F, Arnaldi G 2003 Functional and nonfunctional adrenocortical tumors demonstrate a high responsiveness to low-dose adrenocorticotropin. J Clin Endocrinol Metab 88:1994-1998
49. 2+ in the action of adrenocorticotropin in cultured human adrenal glomerulosa cells. J Clin Invest 98:460-466
50. Plouin PF, Corvol P, Guyene TT, Ménard J 1997 Clinical investigation of the renin-angiotensin-aldosterone system. In: Winearls CG, Davison AM, Cameron S, Grunfeld JP, Kerr DNS, Ritz E, eds. Oxford textbook of clinical nephrology. Oxford, UK: Oxford University Press; 1425-1432