Identification of novel ligands for thiamine pyrophosphate (TPP) riboswitches

Biochemical Society Transactions

Volumn 39, Issue 2, 2011, Pages 652-657

  Cressina, Elena ^a   Chen, Liuhong ^a   Moulin, Michael ^a,b   Leeper, Finian J ^a   Abell, Chris ^a   Smith, Alison G ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Chemical intervention; Fragment screening; Riboswitch; Structure activity relationship; Thiamine analogue; Thiamine pyrophosphate (TPP)

Indexed keywords

APTAMER; COCARBOXYLASE; LIGAND; MESSENGER RNA;

BINDING AFFINITY; BIOPHYSICS; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN RNA BINDING; REGULATORY RNA SEQUENCE; REVIEW; RIBOSWITCH; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BASE SEQUENCE; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; LIGANDS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; RIBOSWITCH; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; THIAMINE PYROPHOSPHATE;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 79953182739     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST0390652     Document Type: Review

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