Comparative strain analysis of Anaplasma phagocytophilum infection and clinical outcomes in a canine model of granulocytic anaplasmosis

Vector-Borne and Zoonotic Diseases

Volumn 11, Issue 3, 2011, Pages 223-229

  Scorpio, Diana G ^a   Dumler, J Stephen ^a   Barat, Nicole C ^a   Cook, Judith A ^a   Barat, Christopher E ^b   Stillman, Brett A ^c   DeBisceglie, Kristen C ^c   Beall, Melissa J ^c   Chandrashekar, Ramaswamy ^c  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STEVENSON UNIVERSITY   (United States)

^c IDEXX LABORATORIES   (United States)

Author keywords

Anaplasma; Dog; Experimental infection; Persistence; Strain

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 18; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; TUMOR NECROSIS FACTOR ALPHA;

ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMATACEAE INFECTION; ANIMAL EXPERIMENT; ANIMAL LAMENESS; ANIMAL MODEL; ANOREXIA; ARTICLE; BACTERIAL LOAD; BACTERIAL STRAIN; BLOOD CELL COUNT; BLOOD CHEMISTRY; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOKINE PRODUCTION; EXPERIMENTAL DOG; FEVER; IN VITRO STUDY; LETHARGY; LEUKOPENIA; LYMPHADENOPATHY; NONHUMAN; PETECHIA; PILOT STUDY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEROCONVERSION; SEROLOGY; THROMBOCYTOPENIA; WEIGHT REDUCTION;

ANAPLASMA PHAGOCYTOPHILUM; ANAPLASMOSIS; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL LOAD; CELL-FREE SYSTEM; CYTOKINES; DISEASE MODELS, ANIMAL; DNA, BACTERIAL; DOGS; GRANULOCYTES; HL-60 CELLS; HUMANS; INJECTIONS, INTRAVENOUS; LYMPHATIC DISEASES; NEUTROPHILS; PILOT PROJECTS; REAL-TIME POLYMERASE CHAIN REACTION; SPECIFIC PATHOGEN-FREE ORGANISMS;

ANAPLASMA; ANAPLASMA PHAGOCYTOPHILUM; CANIS FAMILIARIS;

EID: 79953175992     PISSN: 15303667     EISSN: None     Source Type: Journal    
DOI: 10.1089/vbz.2009.0262     Document Type: Article

References (21)

1. Barbet, AF, Meeus, PF, Bélanger, M, Bowie, MV, et al. Expression of multiple outer membrane protein sequence variants from a single genomic locus of Anaplasma phagocytophilum. Infect Immun 2003; 71:1706-1718. (Pubitemid 36372038)
2. Blas-Machado, U, de la Fuente, J, Blouin, EF, Almazán, C, et al. Experimental infection of C3H/HeJ mice with the NY18 isolate of Anaplasma phagocytophilum. Vet Pathol 2007; 44:64-73. (Pubitemid 46074960)
3. Borjesson, DL, Barthold, SW. The mouse as a model for investigation of human granulocytic ehrlichiosis: current knowledge and future directions. Comp Med 2002; 52:403-413. (Pubitemid 35256125)
4. Choi, KS, Garyu, J, Park, J, Dumler, JS. Diminished adhesion of Anaplasma phagocytophilum-infected neutrophils to endothelial cells is associated with reduced expression of leukocyte surface selectin. Infect Immun 2003; 8:4586-4594. (Pubitemid 36919925)
5. Dumler, JS, Choi, KS, Garcia-Garcia, JC, Barat, NS, et al. Human granulocytic anaplasmosis and Anaplasma phagocytophilum. Emerg Infect Dis 2005; 11:1828-1834. (Pubitemid 43361465)
6. Dumler, JS, Trigiani, ER, Bakken, JS, Aguero-Rosenfeld, ME, Wormser, GP. Serum cytokine responses during acute human granulocytic ehrlichiosis. Clin Diagn Lab Immunol 2000; 7:6-8. (Pubitemid 30051452)
7. Egenvall, A, BjÖ ersdorff, A, LilliehÖÖ k, I, Olsson Engvall, E, et al. Early manifestations of granulocytic ehrlichiosis in dogs inoculated experimentally with a Swedish Ehrlichia species isolate. Vet Rec 1998; 143:412-417. (Pubitemid 128769365)
8. Ewing, SA, Dawson, JE, Panciera, RJ, Mathew, JS, et al. Dogs infected with a human granulocytotropic Ehrlichia spp. (Rickettsiales: Ehrlichieae). J Med Entomol 1997; 34:710-718. (Pubitemid 127460886)
9. Foley, JE, Lerche, NW, Dumler, JS, Madigan, JE. A simian model of human granulocytic ehrlichiosis. Am J Trop Med Hyg 1999; 60:987-993. (Pubitemid 29296226)
10. Franzén, P, Aspan, A, Egenvall, A, Gunnarsson, A, et al. Molecular evidence for persistence of Anaplasma phagocytophilum in the absence of clinical abnormalities in horses after recovery from acute experimental infection. J Vet Intern Med 2009; 23:636-642.
11. Greig, B, Asanovich, KM, Armstrong, PJ, Dumler, JS. Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. J Clin Microbiol 1996; 34:44-48. (Pubitemid 126506890)
12. otopp, JC, Lin, M, Madupu, R, Crabtree, J, et al. Comparative genomics of emerging human ehrlichiosis agents. PLoS Genet2006; 2:e21.
13. Hoyer, KK, Dooms, H, Barron, L, Abbas, AK. Interleukin-2 in the development and control of inflammatory disease. Immunol Rev 2008; 226:19-28.
14. Kim, HY, Mott, J, Zhi, N, Tajima, T, Rikihisa, Y. Cytokine gene expression by peripheral blood leukocytes in horses experimentally infected with Anaplasma phagocytophila. Clin Diagn Lab Immunol 2002; 9:1079-1084. (Pubitemid 34988479)
15. Lapaque, N, Walzer, T, Méresse, S, Vivier, E, Trowsdale, J. Interactions between human NK cells and macrophages in response to Salmonella infection. J Immunol 2009; 182:4339-4348.
16. Lin, Q, Rikihisa, Y, Felek, S, Wang, X, et al. Anaplasma phagocytophilum has a functional msp2 gene that is distinct from p44. Infect Immun 2004; 72:3883-3889. (Pubitemid 38821902)
17. Martin, ME, Caspersen, K, Dumler, JS. Immunopathology and ehrlichial propagation are regulated by interferon-gamma and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am J Pathol 2001; 158:1881-1888. (Pubitemid 32422953)
18. Pedra, JH, Sutterwala, FS, Sukumaran, B, Ogura, Y, et al. ASC/ PYCARD and caspase-1 regulate the IL-18/IFN-gamma axis during Anaplasma phagocytophilum infection. J Immunol 2007; 179:4783-4791.
19. Pusterla, N, Chae, JS, Kimsey, RB, Berger Pusterla, J, et al. Transmission of Anaplasma phagocytophila (human granulocytic ehrlichiosis agent) in horses using experimentally infected ticks (Ixodes scapularis). J Vet Med B Infect Dis Vet Public Health 2002; 49:484-488. (Pubitemid 36100889)
20. Scorpio, DG, Caspersen, K, Ogata, H, Park, J, Dumler, JS. Restricted changes in major surface protein-2 (msp2) transcription after prolonged in vitro passage of Anaplasma phagocytophilum. BMC Microbiol 2004; 4:1.
21. Scorpio, DG, Leutenegger, C, Berger, J, Barat, N, et al. Sequential analysis of Anaplasma phagocytophilum msp2 transcription in murine and equine models of human granulocytic anaplasmosis. Clin Vaccine Immunol 2008; 15:418-424. (Pubitemid 351967062)