Restricted changes in major surface protein-2 (msp2) transcription after prolonged in vitro passage of Anaplasma phagocytophilum

BMC Microbiology

Volumn 4, Issue , 2004, Pages 1-8

  Scorpio, Diana G ^a   Caspersen, Karen ^a   Ogata, Hiroyuki ^b   Park, Jinho ^a,c   Dumler, J Stephen ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CNRS Aix Marseille University   (France)

^c Chonbuk National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; MAJOR SURFACE PROTEIN 2; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; PRIMER DNA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANAPLASMA PHAGOCYTOPHILUM; ANTIGENIC VARIATION; ARTICLE; BACTERIAL STRAIN; CONSENSUS SEQUENCE; CONSERVATION GENETICS; CONTROLLED STUDY; GENE CONVERSION; GENE LOCUS; GENETIC HETEROGENEITY; HISTOGRAM; IMMUNOBLOTTING; IN VITRO STUDY; NONHUMAN; PARALOGY; PROTEIN DOMAIN; RNA TRANSCRIPTION; STRAIN DIFFERENCE;

ANAPLASMA; ANAPLASMA PHAGOCYTOPHILUM; BACTERIA (MICROORGANISMS);

EID: 2942596226     PISSN: 14712180     EISSN: 14712180     Source Type: Journal    
DOI: 10.1186/1471-2180-4-1     Document Type: Article

References (36)

1. Greig B, Asanovich KM, Armstrong PJ, Dumler JS: Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. J Clin Microbiol 1996, 34:44-48.
2. Madigan JE, Gribble D: Equine ehrlichiosis in northern California: 49 cases (1968-1981). J Am Vet Med Assoc 1987, 190:445-448.
3. Bakken JS, Krueth J, Wilson-Nordskog C, Tilden RL, Asanovich K, Dumler JS: Clinical and laboratory characteristics of human granulocytic ehrlichiosis. JAMA 1996, 275:199-205.
4. Stafford KC, Massung RF, Magnarelli LA, IJdo JW, Anderson JF: Infection with agents of human granulocytic ehrlichiosis, Lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut. J Clin Microbiol 1999, 37:2887-2892.
5. Stuen S, Engvall EO, Artursson K: Persistence of Ehrlichia phagocytophila infection in lambs in relation to clinical parameters and antibody responses. Vet Rec 1998, 143:553-555.
6. Asanovich KM, Bakken JS, Madigan JE, Aguero-Rosenfeld M, Wormser GP, Dumler JS: Antigenic diversity of granulocytic Ehrlichia species isolates from humans in Wisconsin, New York, and a California horse. J Infect Dis 1997, 176:1029-1034.
7. Barbet AF, Lundgren A, Yi J, Rurangirwa FR, Palmer GH: Antigenic variation of the ehrlichia Anaplasma marginaleby expression of MSP2 sequence mosaics. Infect Immun 2000, 68:6133-6138.
8. Brayton KA, Knowles DP, McGuire TC, Palmer GH: Efficient use of a small genome to generate antigenic diversity in tick-borne ehrlichial pathogens. Proc Natl Acad Sci USA 2001, 98:4130-4135.
9. French DM, Brown WC, Palmer GH: Emergence of Anaplasma marginale antigenic variants during persistent rickettsemia. Infect Immun 1999, 67:5834-5840.
10. Murphy CL, Storey JR, Recchia J, Doros-Richert LA, Gingrich-Baker C, Munroe K, Bakken JS, Coughlin RT, Beltz GA: Major antigenic proteins of the agent of human granulocytic ehrlichiosis are encoded by members of a multigene family. Infect Immun 1998, 66:3711-3718.
11. IJdo JW, Zhang Y, Magnarelli LA, Fikrig E: Cloning of the gene encoding the 44-kilodalton antigen of the agent of human granulocytic ehrlichiosis and characterization of the humoral response. Infect Immun 1998, 66:3264-3269.
12. Zhi N, Ohasi N, Rikihisa Y: Multiple p44 genes encoding major membrane proteins are expressed in human granulocytic ehrlichiosis agent. J Biol Chem 1999, 274:17828-17836.
13. IJdo JW, Wu C, Telford SR III, Fikrig E: Differential expression of the p44 gene family in the agent of human granulocytic ehrlichiosis. Infect Immun 2002, 70:5295-5298.
14. Zhi N, Ohashi N, Tajima T, Mott J, Stich RW, Grover D, Telford SR III, Lin Q, Rikihisa Y: Transcript heterogeneity of the p44 multigene family in a human granulocytic ehrlichiosis agent transmitted by ticks. Infect Immun 2002, 70:1175-1184.
15. Caspersen K, Park J, Patil S, Dumler JS: Genetic variability and stability of Anaplasma phagocytophila msp2 (p44). Infect Immun 2002, 70:1230-1234.
16. Boeckmann B, Bairoch A, Apweiler R, Blatter MC, Estreicher A, Gasteiger E, Martin MJ, Michoud K, O'Donovan C, Phan I, Pilbout S, Schneider M: The SWISS-PROT protein knowledgebase and its supplement TrEMBL in 2003. Nucleic Acids Res 2003, 31:365-370.
17. Palmer GH, Rurangirwa FR, McElwain TF: Strain composition of the ehrlichia Anaplasma marginale within persistently infected cattle, a mammalian reservoir for tick transmission. J Clin Microbiol 2001, 39:631-635.
18. Rurangirwa FR, Stiller D, Palmer GH: Strain diversity in major surface protein 2 during tick transmission of Anaplasma marginale. Infect Immun 2000, 68:3023-3027.
19. Walls JJ, Asanovich KM, Bakken JS, Dumler JS: Serologic evidence of a natural infection of white-tailed deer with the agent of human granulocytic ehrlichiosis in Wisconsin and Maryland. Clin Diagn Lab Immunol 1998, 5:762-765.
20. Barbour AG, Restrepo BI: Antigenic variation in vector-borne pathogens. Emerg Infect Dis 2000, 6:449-457.
21. Brayton KA, Palmer GH, Lundgren A, Yi J, Barbet AF: Antigenic variation of Anaplasma marginale msp2 occurs by combinatorial gene conversion. Mol Microbiol 2002, 43:1151-1159.
22. Reddy GR, Sulsona CR, Barbet AF, Mahan SM, Burridge MJ, Alleman AR: Molecular characterization of a 28 kDa surface antigen gene family of the tribe Ehrlichieae. Biophys Res Comm 1998, 247:636-643.
23. Reddy GR, Streck CP: Variation in the 28 kDa surface antigen protein multigene locus of isolates of the emerging disease agent Ehrlichia chaffeensis suggests that it plays a role in immune evasion. Mol Cell Biol Res Comm 1999, 1:167-175.
24. Taylor-Robinson A, Phillips RS: Protective CD4+ T-cell lines raised against Plasmodium chabaudi show characteristics of either Th1 or Th2 cells. Parasit Immunol 1993, 15:301-310.
25. Barbet AF, Meeus PF, Belanger M, Bowie MV, Yi J, Lundgren AM, Alleman AR, Wong SJ, Chu FK, Munderloh UG, Jauron SD: Expression of multiple outer membrane protein sequence variants from a single genomic locus of Anaplasma phagocytophilum. Infect Immun 2003, 71:1706-1718.
26. Carlyon JA, Akkoyunlu M, Xia L, Yago T, Wang T, Cummings RD, McEver RP, Fikrig E: Murine neutrophils require α1,3-fucosylation but not PSGL-1 for productive infection with Anaplasma phagocytophilum. Blood 2003, 102:3387-3395.
27. McGarey DJ, Allred DR: Characterization of hemagglutinating components on the Anaplasma marginale initial body surface and identification of possible adhesins. Infect Immun 1994, 62:4587-4593.
28. McGarey DJ, Barbet AF, Palmer GH, McGuire TC, Allred DR: Putative adhesins of Anaplasma marginale: major surface polypeptides 1a and 1b. Infect Immun 1994, 62:4594-4601.
29. Park J, Choi KS, Dumler JS: Major surface protein 2 of Anaplasma phagocytophilum facilitates adherence to granulocytes. Infect Immun 2003, 71:4018-4025.
30. Pusterla N, Madigan JE, Asanovich KM, Chae J-S, DeRock E, Berger-Pusterla J, Lutz H, Dumler JS: Experimental transmission of human granulocytic ehrlichia agent derived from high and low passage cell culture in horses. J Clin Microbiol 2000, 38:1276-1278.
31. Foley JE, Leutenegger CM, Dumler JS, Pedersen NC, Madigan JE: Evidence for modulated immune response to Anaplasma phagocytophila sensu lato in cats with FIV-induced immunosuppression. Comp Immunol Micobiol Infect Dis 2003, 26:103-113.
32. Martin ME, Caspersen K, Dumler JS: Immunopathology and ehrlichial propagation are regulated by interferon-γ and interleukin-10 in a murine model of human granulocytic ehrlichiosis. Am J Pathol 2001, 158:1881-1888.
33. Thompson JD, Higgins DG, Gibson TJ: CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 1994, 22:4673-4680.
34. Page RDM: TREEVIEW: An application to display phylogenetic trees on personal computers. Comput Appl Biosci 1996, 12:357-358.
35. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ: Basic local alignment search tool. J Mol Biol 1990, 215:403-410.
36. Kneller DG, Cohen FE, Langridge R: Improvements in protein secondary structure prediction by an enhanced neural network. J Mol Biol 1990, 214:171-182.