Energy restriction-mimetic agents induce apoptosis in prostate cancer cells in part through epigenetic activation of KLF6 tumor suppressor gene expression

Journal of Biological Chemistry

Volumn 286, Issue 12, 2011, Pages 9968-9976

  Chen, Chun Han ^a,b   Huang, Po Hsien ^a   Chu, Po Chen ^a   Chen, Mei Chuan ^a,b   Chou, Chih Chien ^a   Wang, Dasheng ^a   Kulp, Samuel K ^a   Teng, Che Ming ^b   Wang, Qianben ^a   Chen, Ching Shih ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS; BINDING ELEMENTS; CANCER PREVENTION; CHROMATIN IMMUNOPRECIPITATION ANALYSIS; ENHANCING EFFECT; EPIGENETIC REGULATION; GLUCOSE DEPRIVATION; HISTONE DEACETYLASES; HISTONE H3; INDUCED APOPTOSIS; KRUPPEL-LIKE FACTOR 6; LUCIFERASE REPORTER ASSAYS; NOVEL STRATEGIES; PRO-APOPTOTIC GENES; PROMOTER ACTIVITIES; PROMOTER REGION; PROSTATE CANCER CELLS; PROSTATE CANCERS; SITE DIRECTED MUTAGENESIS; SP1 BINDING SITES; THIAZOLIDINEDIONES; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL REPRESSION; TRIMETHYLATION; TUMOR SUPPRESSOR GENES;

ACETYLATION; ACTIVATION ANALYSIS; AMINO ACIDS; BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; CATALYSTS; CELL DEATH; DISEASES; ENZYMES; GENE EXPRESSION; GENE THERAPY; GLUCOSE; TUMORS;

GENE EXPRESSION REGULATION;

2,4 THIAZOLIDINEDIONE DERIVATIVE; CG 12; ENERGY RESTRICTION MIMETIC AGENT; HISTONE DEACETYLASE; HISTONE H3; HISTONE H3 LYSINE 4; HISTONE H3 LYSINE 4 DEACETYLASE; TRANSCRIPTION FACTOR SP1; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BINDING SITE; CANCER CELL; CELL STRAIN LNCAP; CONTROLLED STUDY; DOWN REGULATION; ENERGY RESTRICTION; EPIGENETICS; GENE EXPRESSION REGULATION; GENE REPRESSION; HISTONE ACETYLATION; KRUPPEL LIKE FACTOR 6 GENE; PRIORITY JOURNAL; PROMOTER REGION; STARVATION; TRANSCRIPTION INITIATION; TUMOR SUPPRESSOR GENE;

ACETYLATION; APOPTOSIS; CELL LINE, TUMOR; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HISTONE DEACETYLASES; HISTONES; HUMANS; HYPOGLYCEMIC AGENTS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MALE; METHYLATION; PROSTATIC NEOPLASMS; PROTO-ONCOGENE PROTEINS; RESPONSE ELEMENTS; SP1 TRANSCRIPTION FACTOR; THIAZOLIDINEDIONES; TUMOR SUPPRESSOR PROTEINS;

EID: 79953166505     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.203240     Document Type: Article

References (38)

1. Kroemer, G., and Pouyssegur, J. (2008) Cancer Cell 13, 472-482
2. Kim, J. W., and Dang, C. V. (2006) Cancer Res. 66, 8927-8930
3. Denko, N. C. (2008) Nat. Rev. Cancer 8, 705-713
4. Elstrom, R. L., Bauer, D. E., Buzzai, M., Karnauskas, R., Harris, M. H., Plas, D. R., Zhuang, H., Cinalli, R. M., Alavi, A., Rudin, C. M., and Thompson, C. B. (2004) Cancer Res. 64, 3892-3899
5. Osthus, R. C., Shim, H., Kim, S., Li, Q., Reddy, R., Mukherjee, M., Xu, Y., Wonsey, D., Lee, L. A., and Dang, C. V. (2000) J. Biol. Chem. 275, 21797-21800
6. Matoba, S., Kang, J. G., Patino, W. D., Wragg, A., Boehm, M., Gavrilova, O., Hurley, P. J., Bunz, F., and Hwang, P. M. (2006) Science 312, 1650-1653
7. Kelloff, G. J., Hoffman, J. M., Johnson, B., Scher, H. I., Siegel, B. A., Cheng, E. Y., Cheson, B. D., O'Shaughnessy, J., Guyton, K. Z., Mankoff, D. A., Shankar, L., Larson, S. M., Sigman, C. C., Schilsky, R. L., and Sullivan, D. C. (2005) Clin. Cancer Res. 11, 2785-2808
8. Wei, S., Kulp, S. K., and Chen, C. S. (2010) J. Biol. Chem. 285, 9780-9791
9. DiFeo, A., Martignetti, J. A., and Narla, G. (2009) Drug Resist. Updates 12, 1-7
10. Narla, G., Heath, K. E., Reeves, H. L., Li, D., Giono, L. E., Kimmelman, A. C., Glucksman, M. J., Narla, J., Eng, F. J., Chan, A. M., Ferrari, A. C., Martignetti, J. A., and Friedman, S. L. (2001) Science 294, 2563-2566
11. Chen, C., Hyytinen, E. R., Sun, X., Helin, H. J., Koivisto, P. A., Frierson, H. F., Jr., Vessella, R. L., and Dong, J. T. (2003) Am. J. Pathol. 162, 1349-1354
12. Kremer-Tal, S., Narla, G., Chen, Y., Hod, E., DiFeo, A., Yea, S., Lee, J. S., Schwartz, M., Thung, S. N., Fiel, I. M., Banck, M., Zimran, E., Thorgeirsson, S. S., Mazzaferro, V., Bruix, J., Martignetti, J. A., Llovet, J. M., and Friedman, S. L. (2007) J. Hepatol. 46, 645-654
13. Ito, G., Uchiyama, M., Kondo, M., Mori, S., Usami, N., Maeda, O., Kawabe, T., Hasegawa, Y., Shimokata, K., and Sekido, Y. (2004) Cancer Res. 64, 3838-3843
14. Reeves, H. L., Narla, G., Ogunbiyi, O., Haq, A. I., Katz, A., Benzeno, S., Hod, E., Harpaz, N., Goldberg, S., Tal-Kremer, S., Eng, F. J., Arthur, M. J., Martignetti, J. A., and Friedman, S. L. (2004) Gastroenterology 126, 1090-1103
15. DiFeo, A., Narla, G., Camacho-Vanegas, O., Nishio, H., Rose, S. L., Buller, R. E., Friedman, S. L., Walsh, M. J., and Martignetti, J. A. (2006) Oncogene 25, 6026-6031
16. Camacho-Vanegas, O., Narla, G., Teixeira, M. S., DiFeo, A., Misra, A., Singh, G., Chan, A. M., Friedman, S. L., Feuerstein, B. G., and Martignetti, J. A. (2007) Int. J. Cancer 121, 1390-1395
17. Sangodkar, J., Shi, J., DiFeo, A., Schwartz, R., Bromberg, R., Choudhri, A., McClinch, K., Hatami, R., Scheer, E., Kremer-Tal, S., Martignetti, J. A., Hui, A., Leung, W. K., Friedman, S. L., and Narla, G. (2009) Eur. J. Cancer 45, 666-676
18. Teixeira, M. S., Camacho-Vanegas, O., Fernandez, Y., Narla, G., DiFeo, A., Lee, B., Kalir, T., Friedman, S. L., Schlecht, N. F., Genden, E. M., Urken, M., Brandwein-Gensler, M., and Martignetti, J. A. (2007) Int. J. Cancer 121, 1976-1983
19. Yang, J., Wei, S., Wang, D. S., Wang, Y. C., Kulp, S. K., and Chen, C. S. (2008) J. Med. Chem. 51, 2100-2107
20. Wei, S., Chuang, H. C., Tsai, W. C., Yang, H. C., Ho, S. R., Paterson, A. J., Kulp, S. K., and Chen, C. S. (2009) Mol. Pharmacol. 76, 47-57
21. Livak, K. J., and Schmittgen, T. D. (2001) Methods 25, 402-408
22. Wang, Q., Carroll, J. S., and Brown, M. (2005) Mol. Cell 19, 631-642
23. Britschgi, A., Trinh, E., Rizzi, M., Jenal, M., Ress, A., Tobler, A., Fey, M. F., Helin, K., and Tschan, M. P. (2008) Oncogene 27, 5706-5716
24. Huang, X., Li, X., and Guo, B. (2008) J. Biol. Chem. 283, 29795-29801
25. Ke, X. S., Qu, Y., Rostad, K., Li, W. C., Lin, B., Halvorsen, O. J., Haukaas, S. A., Jonassen, I., Petersen, K., Goldfinger, N., Rotter, V., Akslen, L. A., Oyan, A. M., and Kalland, K. H. (2009) PLoS ONE 4, e4687
26. Wang, Z., Zang, C., Rosenfeld, J. A., Schones, D. E., Barski, A., Cuddapah, S., Cui, K., Roh, T. Y., Peng, W., Zhang, M. Q., and Zhao, K. (2008) Nat. Genet. 40, 897-903
27. Weake, V. M., and Workman, J. L. (2010) Nat. Rev. Genet. 11, 426-437
28. Yamashita, K., Upadhyay, S., Osada, M., Hoque, M. O., Xiao, Y., Mori, M., Sato, F., Meltzer, S. J., and Sidransky, D. (2002) Cancer Cell 2, 485-495
29. Bott, S. R., Arya, M., Kirby, R. S., and Williamson, M. (2005) Prostate Cancer Prostatic Dis. 8, 321-326
30. Schuettengruber, B., Simboeck, E., Khier, H., and Seiser, C. (2003) Mol. Cell. Biol. 23, 6993-7004
31. Liu, F., Pore, N., Kim, M., Voong, K. R., Dowling, M., Maity, A., and Kao, G. D. (2006) Mol. Biol. Cell 17, 585-597
32. Catteau, A., Rosewell, I., Solomon, E., and Taylor-Papadimitriou, J. (2004) Int. J. Oncol. 25, 5-16
33. Singletary, K., and Milner, J. (2008) Cancer Epidemiol. Biomark. Prev. 17, 1596-1610
34. Safe, S., and Abdelrahim, M. (2005) Eur. J. Cancer 41, 2438-2448
35. Solomon, S. S., Majumdar, G., Martinez-Hernandez, A., and Raghow, R. (2008) Life Sci. 83, 305-312
36. Wierstra, I. (2008) Biochem. Biophys. Res. Commun. 372, 1-13
37. Knoepfler, P. S., Zhang, X. Y., Cheng, P. F., Gafken, P. R., McMahon, S. B., and Eisenman, R. N. (2006) EMBO J. 25, 2723-2734
38. Gehrau, R. C., D'Astolfo, D. S., Dumur, C. I., Bocco, J. L., and Koritschoner, N. P. (2010) PLoS ONE 5, e8929