A novel class of compounds with cutaneous wound healing properties

Journal of Biomedical Nanotechnology

Volumn 6, Issue 5, 2010, Pages 605-611

  Zhou, Zhiguo ^a   Joslin, Steve ^a   Dellinger, Anthony ^a   Ehrich, Marion ^c   Brooks, Brad ^a   Ren, Qing ^b   Rodeck, Ulrich ^b   Lenk, Robert ^a   Kepley, Christopher L ^a  

^a LUNA INNOVATIONS INC   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c VIRGINIA MARYLAND REGIONAL COLLEGE OF VETERINARY MEDICINE   (United States)

Author keywords

Antioxidant; Fullerenes; Nanotechnology; Skin; Wound healing

Indexed keywords

ANTI-INFLAMMATORIES; ANTIOXIDANT; BIOLOGICAL ACTIVITIES; CARBON NANOSPHERE; CELL MIGRATION; CUTANEOUS WOUNDS; DISEASE PROCESS; EX-VIVO; FULLERENE DERIVATIVE; HEALING PROCESS; HUMAN SKIN; IN-VIVO; INHERENT COMPLEXITY; MOUSE MODELS; OXYGEN DEPRIVATION; REACTIVE OXYGEN SPECIES; SINGLE PARAMETER; SKIN IRRITATION; WOUND CLOSURE; WOUND HEALING; WOUND-HEALING TREATMENT;

CYTOLOGY; NANOTECHNOLOGY; OXYGEN;

FULLERENES;

FULLERENE DERIVATIVE; NANOSPHERE; REACTIVE OXYGEN METABOLITE; DERMATOLOGICAL AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CELL MIGRATION; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; EX VIVO STUDY; EXPLANT; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPOXIA; INFECTION; INFLAMMATION; MOUSE; NONHUMAN; OXIDATIVE STRESS; SKIN IRRITATION; WOUND CLOSURE; WOUND HEALING; WOUND HEALING IMPAIRMENT; ANIMAL; CHEMISTRY; DRUG EFFECT; INJURY; PATHOLOGY; SKIN; TREATMENT OUTCOME;

ANIMALS; DERMATOLOGIC AGENTS; FULLERENES; HUMANS; MICE; SKIN; TREATMENT OUTCOME; WOUND HEALING; WOUNDS AND INJURIES;

EID: 79953152657     PISSN: 15507033     EISSN: 15507041     Source Type: Journal    
DOI: 10.1166/jbn.2010.1157     Document Type: Article

References (30)

1. C. A. Andersen and T. S. Roukis, The diabetic foot. Surg. Clin. North. Am. 87, 1149 (2007).
2. R. F. Diegelmann and M. C. Evans, Wound healing: An overview of acute, fibrotic and delayed healing. Front. Biosci. 9, 283 (2004).
3. K. U. Auf Dem, A. Kumin, S. Braun, and S. Werner, Reactive oxygen species and their detoxification in healing skin wounds. J. Investig. Dermatol. Symp. Proc. 1, 106 (2006).
4. M. Schafer and S. Werner, Oxidative stress in normal and impaired wound repair. Pharmacol. Res. 45, 6 (2008).
5. A. Soneja, M. Drews, and T. Malinski, Role of nitric oxide, nitroxidative and oxidative stress in wound healing. Pharmacol. Rep. 57, 108 (2004).
6. N. B. Menke, K. R. Ward, T. M. Witten, D. G. Bonchev, and R. F. Diegelmann, Impaired wound healing. Clin. Dermatol. 25, 19 (2007).
7. I. Juranek and S. Bezek, Controversy of free radical hypothesis: Reactive oxygen species-cause or consequence of tissue injury? Gen. Physiol. Biophys. 24, 263 (2005).
8. A. Parihar, M. S. Parihar, S. Milner, and S. Bhat, Oxidative stress and anti-oxidative mobilization in burn injury. Burns 34, 6 (2008).
9. M. Rojkind, J. A. Dominguez-Rosales, N. Nieto, and P. Greenwel, Role of hydrogen peroxide and oxidative stress in healing responses. Cell Mol, Life Sci. 59, 1872 (2002).
10. H. Steiling, B. Munz, S. Werner, and M. Brauchle, Different types of ROS-scavenging enzymes are expressed during cutaneous wound repair. Exp. Cell Res. 247, 484 (1999).
11. A. Dellinger, Z. Zhou, R. Lenk, D. Macfarland, and C. L. Kepley, Fullerene nanomaterials inhibit phorbol myristate acetate-induced inflammation. Exp. Dermatol. 18, 1079 (2009).
12. J. J. Ryan, H. R. Bateman, A. Stover, G. Gomez, S. K. Norton, W. Zhao, L. B. Schwartz, R. Lenk, and C. L. Kepley, Fullerene nanomaterials inhibit the allergic response. J. Immunol. 179, 665 (2007).
13. Y. Li, H. Zhu, P. Kuppusamy, V. Roubaud, J. L. Zweier, and M. A. Trush, Validation of lucigenin (bis-N-methylacridinium) as a chemilumigenic probe for detecting superoxide anion radical production by enzymatic and cellular systems. J. Biol. Chem. 273, 2015 (1998).
14. P. Boukamp, R. T. Petrussevska, D. Breitkreutz, J. Hornung, A. Markham, and N. E. Fusenig, Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line. J. Cell Biol. 106, 761 (1998).
15. N. E. Fusenig, D. Breitkreutz, R. T. Dzarlieva, P. Boukamp, A. Bohnert, and W. Tilgen, Growth and differentiation characteristics of transformed keratinocytes from mouse and human skin in vitro and in vivo. J. Invest. Dermatol. 81, 168s (1983).
16. C. C. Liang, A. Y. Park, and J. L. Guan, In vitro scratch assay: A convenient and inexpensive method for analysis of cell migration in vitro. Nat. Protoc. 2, 329 (2007).
17. G. Kratz, Modeling of wound healing processes in human skin using tissue culture. Microsc. Res. Tech. 42, 345 (1998).
18. I. Moll, P. Houdek, S. Schafer, U. Nuber, and R. Moll, Diversity of desmosomal proteins in regenerating epidermis: Immunohistochemical study using a human skin organ culture model. Arch. Dermatol. Res. 291, 437 (1999).
19. Z. Zhou, D. I. Schuster, and S. R. Wilson, J. Org. Chem. 68, 7612 (2003).
20. S. R. Wilson, D. I. Schuster, B. Nuber, M. Meier, M. Prato, and R. Taylor, Fullerenes: Chemistry, Physics, and Technology, edited by K. Kadish and R. Ruoff, John Wiley & Sons, NY (2000).
21. N. S. Gibran, S. Boyce, and D. G. Greenhalgh, Cutaneous wound healing. J. Burn Care Res. 28, 577 (2007).
22. L. B. Schwartz and T. F. Huff, Biology of mast cells and basophils, Allergy: Principals and Practice, edited by E. Middleton, Jr., C. E. Reed, E. F. Ellis, N. F. Adkinson, Jr., J. W. Yunginger, and W. W. Busse, Mosby-Year Book, Inc., St. Louis (1993), pp. 135-168.
23. C. L. Gallant-Behm, K. A. Hildebrand, and D. A. Hart, The mast cell stabilizer ketotifen prevents development of excessive skin wound contraction and fibrosis in red Duroc pigs. Wound Repair Regen. 16, 226 (2008).
24. P. Martin and S. J. Leibovich, Inflammatory cells during wound repair: the good, the bad and the ugly. Trends Cell Biol. 15, 599 (2005).
25. M. Artuc, B. Hermes, U. M. Steckelings, A. Grutzkau, and B. M. Henz, Mast cells and their mediators in cutaneous wound healing - Active participants or innocent bystanders? Exp. Dermatol. 8, 1 (1998).
26. K. Weller, K. Foitzik, R. Paus, W. Syska, and M. Maurer, Mast cells are required for normal healing of skin wounds in mice. FASEB. J. 20, 2366 (2006).
27. E. I. Egozi, A. M. Ferreira, A. L. Burns, R. L. Gamelli, and L. A. Dipietro, Mast cells modulate the inflammatory but not the proliferative response in healing wounds. Wound Repair Regen. 11, 46 (2003).
28. Y. Iba, A. Shibata, M. Kato, and T. Masukawa, Possible involvement of mast cells in collagen remodeling in the late phase of cutaneous wound healing in mice. Int. Immunopharmacol. 4, 1873 (2004).
29. S. K. Norton, A. Dellinger, Z. Zhou, D. Macfarland, B. Vonakis, D. Conrad, and C. L. Kepley, A new class of human mast cell and peripheral blood basophil stabilizers that differentially control allergic mediator release. Clin. Transit. Sci. 4, 158 (2010).
30. Z. Zhou, R. P. Lenk, A. Dellinger, S. R. Wilson, R. Sadler, and C. L. Kepley, Liposomal formulation of amphiphilic fullerene antioxidants. Bioconjug Chem. 9, 1656 (2010).