Advanced computational biology methods identify molecular switches for malignancy in an EGF mouse model of liver cancer

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Stegmaier, Philip ^a   Voss, Nico ^a   Meier, Tatiana ^b,c   Kel, Alexander ^a,d,e   Wingender, Edgar ^a,d,f   Borlak, Juergen ^b,c  

^a BIOBASE GMBH   (Germany)

^b FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d GeneXplain GmbH   (Germany)

^e INSTITUTE OF CHEMICAL BIOLOGY AND FUNDAMENTAL MEDICINE   (Russian Federation)

^f UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AURORA A KINASE; CHEMOKINE RECEPTOR CXCR4; CYCLIN B1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DNA; EARLY GROWTH RESPONSE FACTOR 1; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; INTERLEUKIN 1 RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MYC PROTEIN; NUCLEAR PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN C FOS; PROTEIN C JUN; PROTEIN P107; PROTEIN P130; PROTEIN P53; SMAD3 PROTEIN; SOMATOMEDIN; SOMATOMEDIN B; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 2; TRANSCRIPTION FACTOR FOXC1; TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOCRINE EFFECT; BIOLOGY; CELL CYCLE REGULATION; CONTROLLED STUDY; DISEASE MODEL; GEL MOBILITY SHIFT ASSAY; GENE REGULATORY NETWORK; GENETIC ANALYSIS; LIVER CANCER; LIVER CARCINOGENESIS; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DNA INTERACTION; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TUMOR CELL; TUMOR GROWTH; UPREGULATION; WESTERN BLOTTING; ANIMAL; BINDING SITE; CELL CYCLE; CLUSTER ANALYSIS; DOWN REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; LIPID METABOLISM; LIVER TUMOR; METABOLISM; METHODOLOGY; PATHOLOGY; PRECANCER; PROTEIN BINDING; TUMOR GENE;

MUS MUSCULUS;

ANIMALS; BINDING SITES; CELL CYCLE; CLUSTER ANALYSIS; COMPUTATIONAL BIOLOGY; DISEASE MODELS, ANIMAL; DNA, NEOPLASM; DOWN-REGULATION; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE REGULATORY NETWORKS; GENES, NEOPLASM; LIPID METABOLISM; LIVER NEOPLASMS; MICE; MICE, TRANSGENIC; PRECANCEROUS CONDITIONS; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 79953151636     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017738     Document Type: Article

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