Viral double-stranded RNAs from vaccinia virus early or intermediate gene transcripts possess PKR activating function, resulting in NF-κB activation, when the K1 protein is absent or mutated

Journal of Biological Chemistry

Volumn 286, Issue 10, 2011, Pages 7765-7778

  Willis, Kristen L ^a   Langland, Jeffrey O ^b,c   Shisler, Joanna L ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Southwest College Naturopathic Med   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING FUNCTION; ACTIVATION PATHWAY; ANTI-VIRAL EFFECTS; APOPTOSIS; DOUBLE-STRANDED RNA; GENE TRANSCRIPTIONS; GENE TRANSCRIPTS; HELA CELL; INFECTED CELLS; INHIBITORY FUNCTION; PROTEIN SYNTHESIS; VACCINIA VIRUS;

CELL DEATH; CHEMICAL ACTIVATION; GENES; NUCLEIC ACIDS; POLYMERASE CHAIN REACTION; PROTEINS; RNA; SYNTHESIS (CHEMICAL); VIRUSES;

TRANSCRIPTION;

DOUBLE STRANDED RNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MICROORGANISM PROTEIN; PROTEIN KINASE RNA; UNCLASSIFIED DRUG; VACCINIA VIRUS E3 PROTEIN; VACCINIA VIRUS K1 PROTEIN; VACCINIA VIRUS K3 PROTEIN; VIRUS PROTEIN; VIRUS RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE ACTIVATION; GENE FUNCTION; GENE MUTATION; GENE REPLICATION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; NONHUMAN; POXVIRUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN RNA BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; SIGNAL TRANSDUCTION; VACCINIA; VACCINIA VIRUS; VIRAL GENETICS; VIRUS SURVIVAL;

ANIMALS; ENZYME ACTIVATION; HELA CELLS; HUMANS; MUTATION; NF-KAPPA B; PROTO-ONCOGENE PROTEINS C-AKT; RABBITS; RNA, DOUBLE-STRANDED; RNA, VIRAL; TRANSCRIPTION, GENETIC; VACCINIA; VACCINIA VIRUS; VIRAL PROTEINS;

POXVIRIDAE; VACCINIA VIRUS;

EID: 79953126940     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.194704     Document Type: Article

References (47)

1. Raven, J. F., and Koromilas, A. E. (2008) Cell Cycle 7, 1146-1150
2. García, M. A., Meurs, E. F., and Esteban, M. (2007) Biochimie 89, 799-811
3. Moss, B. (2007) in Fields Virology (Knipe, D., and Howley, P., eds) 5th Ed., pp. 2905-2946, Lippincott Williams & Wilkins, Philadelphia
4. Condit, R. C., and Niles, E. G. (2002) Biochim. Biophys. Acta 1577, 325-336
5. Chang, H. W., Watson, J. C., and Jacobs, B. L. (1992) Proc. Natl. Acad. Sci. U.S.A. 89, 4825-4829
6. Langland, J. O., and Jacobs, B. L. (2002) Virology 299, 133-141
7. Willis, K. L., Patel, S., Xiang, Y., and Shisler, J. L. (2009) Virology 394, 73-81
8. Ramsey-Ewing, A. L., and Moss, B. (1996) Virology 222, 75-86
9. Lynch, H. E., Ray, C. A., Oie, K. L., Pollara, J. J., Petty, I. T., Sadler, A. J., Williams, B. R., and Pickup, D. J. (2009) Virology 391, 177-186
10. Gil, J., Rullas, J., Alcamí, J., and Esteban, M. (2001) J. Gen. Virol. 82, 3027-3034
11. Myskiw, C., Arsenio, J., van Bruggen, R., Deschambault, Y., and Cao, J. (2009) J. Virol. 83, 6757-6768
12. Zhang, P., Jacobs, B. L., and Samuel, C. E. (2008) J. Virol. 82, 840-848
13. Shisler, J. L., and Jin, X. L. (2004) J. Virol. 78, 3553-3560
14. Meng, X., and Xiang, Y. (2006) Virology 353, 220-233
15. Jacobs, B. L., Langland, J. O., Kibler, K. V., Denzler, K. L., White, S. D., Holechek, S. A., Wong, S., Huynh, T., and Baskin, C. R. (2009) Antiviral Res. 84, 1-13
16. Weaver, J. R., Shamim, M., Alexander, E., Davies, D. H., Felgner, P. L., and Isaacs, S. N. (2007) Virus Res. 130, 269-274
17. Gedey, R., Jin, X. L., Hinthong, O., and Shisler, J. L. (2006) J. Virol. 80, 8676-8685
18. Bond, M., Chase, A. J., Baker, A. H., and Newby, A. C. (2001) Cardiovasc. Res. 50, 556-565
19. Johnson, C. M., Lyle, E. A., Omueti, K. O., Stepensky, V. A., Yegin, O., Alpsoy, E., Hamann, L., Schumann, R. R., and Tapping, R. I. (2007) J. Immunol. 178, 7520-7524
20. Martin, S., and Shisler, J. L. (2009) Virology 390, 298-306
21. Yang, Z., Bruno, D. P., Martens, C. A., Porcella, S. F., and Moss, B. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 11513-11518
22. Perkus, M. E., Goebel, S. J., Davis, S. W., Johnson, G. P., Limbach, K., Norton, E. K., and Paoletti, E. (1990) Virology 179, 276-286
23. Hsiao, J. C., Chung, C. S., Drillien, R., and Chang, W. (2004) Virology 329, 199-212
24. Esteban, M., and Metz, D. H. (1973) J. Gen. Virol. 20, 111-115
25. Beaud, G., and Dru, A. (1980) Virology 100, 10-21
26. Weber, F., Wagner, V., Rasmussen, S. B., Hartmann, R., and Paludan, S. R. (2006) J. Virol. 80, 5059-5064
27. Pichlmair, A., Schulz, O., Tan, C. P., Rehwinkel, J., Kato, H., Takeuchi, O., Akira, S., Way, M., Schiavo, G., and Reis e Sousa, C. (2009) J. Virol. 83, 10761-10769
28. Li, Y., Meng, X., Xiang, Y., and Deng, J. (2010) J. Virol. 84, 3331-3338
29. Kerr, I. M., Brown, R. E., and Ball, L. A. (1974) Nature 250, 57-59
30. Kerr, I. M., Friedman, R. M., Brown, R. E., Ball, L. A., and Brown, J. C. (1974) J. Virol. 13, 9-21
31. Friedman, R. M., Esteban, R. M., Metz, D. H., Tovell, D. R., Kerr, I. M., and Williamson, R. (1972) FEBS Lett. 24, 273-277
32. Beattie, E., Tartaglia, J., and Paoletti, E. (1991) Virology 183, 419-422
33. Baldick, C. J., Jr., and Moss, B. (1993) J. Virol. 67, 3515-3527
34. Ludwig, H., Suezer, Y., Waibler, Z., Kalinke, U., Schnierle, B. S., and Sutter, G. (2006) J. Gen. Virol. 87, 1145-1155
35. Shuman, S., and Moss, B. (1988) J. Biol. Chem. 263, 6220-6225
36. Yuen, L., and Moss, B. (1987) Proc. Natl. Acad. Sci. U.S.A. 84, 6417-6421
37. Earl, P. L., Hügin, A. W., and Moss, B. (1990) J. Virol. 64, 2448-2451
38. Boone, R. F., Parr, R. P., and Moss, B. (1979) J. Virol. 30, 365-374
39. Robertson, H. D., and Mathews, M. B. (1996) Biochimie 78, 909-914
40. Ludwig, H., Mages, J., Staib, C., Lehmann, M. H., Lang, R., and Sutter, G. (2005) J. Virol. 79, 2584-2596
41. Backes, S., Sperling, K. M., Zwilling, J., Gasteiger, G., Ludwig, H., Kremmer, E., Schwantes, A., Staib, C., and Sutter, G. (2010) J. Gen. Virol. 91, 470-482
42. Bayliss, C. D., and Condit, R. C. (1993) Virology 194, 254-262
43. Beattie, E., Paoletti, E., and Tartaglia, J. (1995) Virology 210, 254-263
44. Nájera, J. L., Gómez, C. E., Domingo-Gil, E., Gherardi, M. M., and Esteban, M. (2006) J. Virol. 80, 6033-6047
45. Langland, J. O., Cameron, J. M., Heck, M. C., Jancovich, J. K., and Jacobs, B. L. (2006) Virus Res. 119, 100-110
46. Gil, J., García, M. A., Gomez-Puertas, P., Guerra, S., Rullas, J., Nakano, H., Alcamí, J., and Esteban, M. (2004) Mol. Cell. Biol. 24, 4502-4512
47. Chang, S. J., Hsiao, J. C., Sonnberg, S., Chiang, C. T., Yang, M. H., Tzou, D. L., Mercer, A. A., and Chang, W. (2009) J. Virol. 83, 4140-4152