Early viral protein synthesis is necessary for NF-κB activation in modified vaccinia Ankara (MVA)-infected 293 T fibroblast cells

Virology

Volumn 390, Issue 2, 2009, Pages 298-306

  Martin, Stefani ^a   Shisler, Joanna L ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

MVA; NF B; Vaccine; Vaccinia

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; CELL STRAIN HEK293; CONTROLLED STUDY; ENDOCYTOSIS; ENZYME PHOSPHORYLATION; FIBROBLAST; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOGENICITY; MODIFIED VACCINIA ANKARA VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; UPREGULATION; VACCINIA VIRUS; VIRUS CELL INTERACTION; VIRUS INFECTION;

CELL LINE; FIBROBLASTS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; NF-KAPPA B; PHOSPHORYLATION; VACCINIA VIRUS; VIRAL PROTEINS;

MONKEYPOX VIRUS; VACCINIA VIRUS; VARIOLA;

EID: 67649992314     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.05.014     Document Type: Article

References (31)

1. Alcami A., and Smith G.L. A soluble receptor for interleukin-1 beta encoded by vaccinia virus: a novel mechanism of virus modulation of the host response to infection. Cell 71 1 (1992) 153-167
2. Alcami A., Khanna A., Paul N.L., and Smith G.L. Vaccinia virus strains Lister, USSR and Evans express soluble and cell-surface tumour necrosis factor receptors. J. Gen. Virol. 80 Pt 4 (1999) 949-959
3. Baldi L., Brown K., Franzoso G., and Siebenlist U. Critical role for lysines 21 and 22 in signal-induced, ubiquitin-mediated proteolysis of I kappa B-alpha. J. Biol. Chem. 271 1 (1996) 376-379
4. Bowie A., Kiss-Toth E., Symons J.A., Smith G.L., Dower S.K., and O'Neill L.A. A46R and A52R from vaccinia virus are antagonists of host IL-1 and toll-like receptor signaling. Proc. Natl. Acad. Sci. U.S.A. 97 18 (2000) 10162-10167
5. Chen Z., Hagler J., Palombella V.J., Melandri F., Scherer D., Ballard D., and Maniatis T. Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway. Genes Dev. 9 13 (1995) 1586-1597
6. DiDonato J.A., Hayakawa M., Rothwarf D.M., Zandi E., and Karin M. A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388 6642 (1997) 548-554
7. Drillien R., Spehner D., and Hanau D. Modified vaccinia virus Ankara induces moderate activation of human dendritic cells. J. Gen. Virol. 85 Pt 8 (2004) 2167-2175
8. Esteban M., and Metz D.H. Early virus protein synthesis in vaccinia virus-infected cells. J. Gen. Virol. 19 2 (1973) 201-206
9. Gedey R., Jin X.L., Hinthong O., and Shisler J.L. Poxviral regulation of the host NF-kappaB response: the vaccinia virus M2L protein inhibits induction of NF-kappaB activation via an ERK2 pathway in virus-infected human embryonic kidney cells. J. Virol. 80 17 (2006) 8676-8685
10. Gilmore T.D. Introduction to NF-kappaB: players, pathways, perspectives. Oncogene 25 51 (2006) 6680-6684
11. Guermonprez P., Valladeau J., Zitvogel L., Thery C., and Amigorena S. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol. 20 (2002) 621-667
12. Guerra S., Najera J.L., Gonzalez J.M., Lopez-Fernandez L.A., Climent N., Gatell J.M., Gallart T., and Esteban M. Distinct gene expression profiling after infection of immature human monocyte-derived dendritic cells by the attenuated poxvirus vectors MVA and NYVAC. J. Virol. 81 16 (2007) 8707-8721
13. Hiscott J., Nguyen T.L., Arguello M., Nakhaei P., and Paz S. Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene 25 51 (2006) 6844-6867
14. Hoffmann A., Natoli G., and Ghosh G. Transcriptional regulation via the NF-kappaB signaling module. Oncogene 25 51 (2006) 6706-6716
15. Huang C.Y., Lu T.Y., Bair C.H., Chang Y.S., Jwo J.K., and Chang W. A novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis. J. Virol. 82 16 (2008) 7988-7999
16. Ichihashi Y., Takahashi T., and Oie M. Identification of a vaccinia virus penetration protein. Virology 202 2 (1994) 834-843
17. Kuang E., Wan Q., Li X., Xu H., Liu Q., and Qi Y. ER Ca2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). J. Cell. Physiol. 204 2 (2005) 549-559
18. Ludwig H., Mages J., Staib C., Lehmann M.H., Lang R., and Sutter G. Role of viral factor E3L in modified vaccinia virus Ankara infection of human HeLa cells: regulation of the virus life cycle and identification of differentially expressed host genes. J. Virol. 79 4 (2005) 2584-2596
19. Ludwig H., Suezer Y., Waibler Z., Kalinke U., Schnierle B.S., and Sutter G. Double-stranded RNA-binding protein E3 controls translation of viral intermediate RNA, marking an essential step in the life cycle of modified vaccinia virus Ankara. J. Gen. Virol. 87 Pt 5 (2006) 1145-1155
20. Mayr A., Hochstein-Mintzel V., and Stickl H. Creation of an attenuated strain of Ankara. MVA Infection 3 (1975) 6-14
21. Mercurio F., Zhu H., Murray B.W., Shevchenko A., Bennett B.L., Li J., Young D.B., Barbosa M., Mann M., Manning A., and Rao A. IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278 5339 (1997) 860-866
22. Moss B. Poxviridae: the viruses and their replication. In: Knipe D., and Howley P. (Eds). Fields Virology. Fifth ed. Vol. 2 (2007), Lippincott Williams and Wilkins, Philadelphia 2905-2946 2 vol
23. Nichols D.B., and Shisler J.L. The MC160 protein expressed by the dermatotropic poxvirus molluscum contagiosum virus prevents tumor necrosis factor alpha-induced NF-kappaB activation via inhibition of I kappa kinase complex formation. J. Virol. 80 2 (2006) 578-586
24. Oie K.L., and Pickup D.J. Cowpox virus and other members of the orthopoxvirus genus interfere with the regulation of NF-kappaB activation. Virology 288 1 (2001) 175-187
25. Ramsey-Ewing A., and Moss B. Apoptosis induced by a postbinding step of vaccinia virus entry into Chinese hamster ovary cells. Virology 242 1 (1998) 138-149
26. Rowe H.M., Lopes L., Brown N., Efklidou S., Smallie T., Karrar S., Kaye P.M., and Collins M.K. Expression of vFLIP in a lentiviral vaccine vector activates NF-{kappa}B, matures dendritic cells and increases CD8+ T cell responses. J. Virol. (2008)
27. Samuelsson C., Hausmann J., Lauterbach H., Schmidt M., Akira S., Wagner H., Chaplin P., Suter M., O'Keeffe M., and Hochrein H. Survival of lethal poxvirus infection in mice depends on TLR9, and therapeutic vaccination provides protection. J. Clin. Invest. 118 5 (2008) 1776-1784
28. Shisler J.L., and Jin X.L. The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradation. J. Virol. 78 7 (2004) 3553-3560
29. Tsung K., Yim J.H., Marti W., Buller R.M., and Norton J.A. Gene expression and cytopathic effect of vaccinia virus inactivated by psoralen and long-wave UV light. J. Virol. 70 1 (1996) 165-171
30. Waibler Z., Anzaghe M., Ludwig H., Akira S., Weiss S., Sutter G., and Kalinke U. Modified vaccinia virus Ankara induces Toll-like receptor-independent type I interferon responses. J. Virol. 81 22 (2007) 12102-12110
31. Weaver J.R., Shamim M., Alexander E., Davies D.H., Felgner P.L., and Isaacs S.N. The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein. Virus Res. 130 1-2 (2007) 269-274