The effect of the vaccinia K1 protein on the PKR-eIF2α pathway in RK13 and HeLa cells

Virology

Volumn 394, Issue 1, 2009, Pages 73-81

  Willis, Kristen L ^a   Patel, Samir ^a   Xiang, Yan ^b   Shisler, Joanna L ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b Mays Cancer Center at UT Health San Antonio   (United States)

Author keywords

eIF2 ; Host range; K1L; PKR; Vaccinia

Indexed keywords

PROTEIN KINASE R; UNCLASSIFIED DRUG; VACCINIA K1 PROTEIN; VIRUS PROTEIN;

ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; HELA CELL; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; VACCINIA VIRUS; VIRUS REPLICATION; WILD TYPE;

ANIMALS; CELL LINE; EIF-2 KINASE; EUKARYOTIC INITIATION FACTOR-2; HUMANS; PHOSPHORYLATION; RABBITS; VACCINIA VIRUS; VIRAL PROTEINS; VIRUS REPLICATION;

VACCINIA VIRUS;

EID: 70350134783     PISSN: 00426822     EISSN: 10960341     Source Type: Journal    
DOI: 10.1016/j.virol.2009.08.020     Document Type: Article

References (29)

1. Antoine G., Scheiflinger F., Dorner F., and Falkner F.G. The complete genomic sequence of the modified vaccinia Ankara strain: comparison with other orthopoxviruses. Virology 244 2 (1998) 365-396
2. Bork P. Hundreds of ankyrin-like repeats in functionally diverse proteins: mobile modules that cross phyla horizontally?. Proteins 17 4 (1993) 363-374
3. Bradley R.R., and Terajima M. Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein. Virus Res. 114 1-2 (2005) 104-112
4. Chang H.W., Watson J.C., and Jacobs B.L. The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase. Proc. Natl. Acad. Sci. U. S. A. 89 11 (1992) 4825-4829
5. Chang S.J., Hsiao J.C., Sonnberg S., Chiang C.T., Yang M.H., Tzou D.L., Mercer A.A., and Chang W. Poxvirus host range protein CP77 contains an F-box-like domain that is necessary to suppress NF-kappaB activation by tumor necrosis factor alpha but is independent of its host range function. J. Virol. 83 9 (2009) 4140-4152
6. Garcia M.A., Meurs E.F., and Esteban M. The dsRNA protein kinase PKR: virus and cell control. Biochimie 89 6-7 (2007) 799-811
7. Hsiao J.C., Chung C.S., Drillien R., and Chang W. The cowpox virus host range gene, CP77, affects phosphorylation of eIF2 alpha and vaccinia viral translation in apoptotic HeLa cells. Virology 329 1 (2004) 199-212
8. Lee S.B., and Esteban M. The interferon-induced double-stranded RNA-activated protein kinase induces apoptosis. VIrology 199 (1994) 491-496
9. Maran A., Maitra R.K., Kumar A., Dong B., Xiao W., Li G., Williams B.R., Torrence P.F., and Silverman R.H. Blockage of NF-kappa B signaling by selective ablation of an mRNA target by 2-5A antisense chimeras. Science 265 5173 (1994) 789-792
10. Meng X., and Xiang Y. Vaccinia virus K1L protein supports viral replication in human and rabbit cells through a cell-type-specific set of its ankyrin repeat residues that are distinct from its binding site for ACAP2. Virology 353 1 (2006) 220-233
11. Meng X., Chao J., and Xiang Y. Identification from diverse mammalian poxviruses of host-range regulatory genes functioning equivalently to vaccinia virus C7L. Virology 372 2 (2008) 372-383
12. Moss B. Poxviridae: the viruses and their replication. In: Knipe D., and Howley P. (Eds). "Fields Virology, Fifth edition" 2 (2007), Lippincott Williams & Wilkins, Philadelphia 2905-2946 2 vols
13. Najera J.L., Gomez C.E., Domingo-Gil E., Gherardi M.M., and Esteban M. Cellular and biochemical differences between two attenuated poxvirus vaccine candidates (MVA and NYVAC) and role of the C7L gene. J. Virol. 80 12 (2006) 6033-6047
14. Perkus M.E., Goebel S.J., Davis S.W., Johnson G.P., Limbach K., Norton E.K., and Paoletti E. Vaccinia virus host range genes. Virology 179 1 (1990) 276-286
15. Prostko C.R., Dholakia J.N., Brostrom M.A., and Brostrom C.O. Activation of the double-stranded RNA-regulated protein kinase by depletion of endoplasmic reticular calcium stores. J. Biol. Chem. 270 11 (1995) 6211-6215
16. Proud C.G. eIF2 and the control of cell physiology. Semin. Cell. Dev. Biol. 16 1 (2005) 3-12
17. Ramsey-Ewing A.L., and Moss B. Complementation of a vaccinia virus host-range K1L gene deletion by the nonhomologous CP77 gene. Virology 222 1 (1996) 75-86
18. Rivas C., Gil J., Melkova Z., Esteban M., and Diaz-Guerra M. Vaccinia virus E3L protein is an inhibitor of the interferon (i.f.n.)-induced 2-5A synthetase enzyme. Virology 243 2 (1998) 406-414
19. Romano P.R., Zhang F., Tan S.L., Garcia-Barrio M.T., Katze M.G., Dever T.E., and Hinnebusch A.G. Inhibition of double-stranded RNA-dependent protein kinase PKR by vaccinia virus E3: role of complex formation and the E3 N-terminal domain. Mol. Cell. Biol. 18 12 (1998) 7304-7316
20. Sedgwick S.G., and Smerdon S.J. The ankyrin repeat: a diversity of interactions on a common structural framework. Trends Biochem. Sci. 24 8 (1999) 311-316
21. Sharp T.V., Moonan F., Romashko A., Joshi B., Barber G.N., and Jagus R. The vaccinia virus E3L gene product interacts with both the regulatory and the substrate binding regions of PKR: implications for PKR autoregulation. Virology 250 2 (1998) 302-315
22. Shisler J.L., and Jin X.L. The vaccinia virus K1L gene product inhibits host NF-kappaB activation by preventing IkappaBalpha degradation. J. Virol. 78 7 (2004) 3553-3560
23. Shors T., Kibler K.V., Perkins K.B., Seidler-Wulff R., Banaszak M.P., and Jacobs B.L. Complementation of vaccinia virus deleted of the E3L gene by mutants of E3L. Virology 239 2 (1997) 269-276
24. Walsh D., Arias C., Perez C., Halladin D., Escandon M., Ueda T., Watanabe-Fukunaga R., Fukunaga R., and Mohr I. Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells. Mol. Cell. Biol. 28 8 (2008) 2648-2658
25. Weaver J.R., Shamim M., Alexander E., Davies D.H., Felgner P.L., and Isaacs S.N. The identification and characterization of a monoclonal antibody to the vaccinia virus E3 protein. Virus Res. 130 1-2 (2007) 269-274
26. Werden S.J., Rahman M.M., and McFadden G. Poxvirus host range genes. Adv. Virus Res. 71 (2008) 135-171
27. Yang Y.L., Reis L.F., Pavlovic J., Aguzzi A., Schafer R., Kumar A., Williams B.R., Aguet M., and Weissmann C. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J. 14 24 (1995) 6095-6106
28. Zhang P., Jacobs B.L., and Samuel C.E. Loss of protein kinase PKR expression in human HeLa cells complements the vaccinia virus E3L deletion mutant phenotype by restoration of viral protein synthesis. J. Virol. 82 2 (2008) 840-848
29. Zhang P., Langland J.O., Jacobs B.L., and Samuel C.E. Protein kinase PKR-dependent activation of mitogen activated protein kinases occurs through mitochondrial adapter IPS-1 and is antagonized by vaccinia virus E3L. J. Virol. 83 11 (2009) 5718-5725