Down-regulation of ABCC11 protein (MRP8) in human breast cancer

Experimental Oncology

Volumn 33, Issue 1, 2011, Pages 42-46

  Sosonkina, N ^a   Nakashima, M ^b   Ohta, T ^a   Niikawa, N ^a   Starenki, D ^a  

^a HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^b NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

Author keywords

ABCC11 mRNA expression; Breast cancer; MRP8 expression; Normal breast

Indexed keywords

CALGRANULIN A; DNA; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; MESSENGER RNA; RNA;

ARTICLE; CANCER INVASION; CHEMOSENSITIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EPITHELIUM CELL; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENOTYPE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; MYOEPITHELIUM CELL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SINGLE NUCLEOTIDE POLYMORPHISM;

ATP-BINDING CASSETTE TRANSPORTERS; BREAST NEOPLASMS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; RNA, MESSENGER;

EID: 79953123298     PISSN: 18129269     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Sarkadi B, Muller M, Hollo Z. The multidrug transporters-proteins of an ancient immune system. Immunol Lett 1996; 54: 215-9. (Pubitemid 27086928)
2. Dean M. ABC transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol Neoplasia 2009; 14: 3-9.
3. Chen ZS, Guo Y, Belinsky MG, et al. Transport of bile acids, sulfated steroids, estradiol 17-beta-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11). Mol Pharmacol 2005; 67: 545-57. (Pubitemid 40216748)
4. Guo Y, Kotova E, Chen ZS, et al. MRP8, ATP-binding cassette C11 (ABCC11), is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines 2′,3′-dideoxycytidine and 9′-(2′- phosphonylmethoxyethyl)adenine. J Biol Chem 2003; 278: 29509-14. (Pubitemid 36962331)
5. Oguri T, Bessho Y, Achiwa H, et al. MRP8/ABCC11 directly confers resistance to 5-fluorouracil. Mol Cancer Ther 2007; 6: 122-7. (Pubitemid 46206674)
6. Uemura T, Oguri T, Ozasa H, et al. ABCC11/MRP8 confers pemetrexed resistance in lung cancer. Cancer Sci 2010; 101: 2404-10.
7. Burger H, Foekens JA, Look MP, et al. RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clin Cancer Res 2003; 9: 827-36. (Pubitemid 36182621)
8. Bera TK, Lee S, Salvatore G, et al. MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer. Mol Med 2001; 7: 509-16.
9. Szakacs G, Annereau JP, Lababidi S, et al. Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells. Cancer Cell 2004; 6: 129-37. (Pubitemid 39485685)
10. Honorat M, Mesnier A, Vendrell J, et al. ABCC11 expression is regulated by estrogen in MCF7 cells, correlated with estrogen receptor alpha expression in postmenopausal breast tumors and overexpressed in tamoxifen-resistant breast cancer cells. Endocr Relat Cancer 2008; 15: 125-38. (Pubitemid 351449733)
11. Martin A, Saathoff M, Kuhn F, et al. A functional ABCC11 allele is essential in the biochemical formation of human axillary odor. J Invest Dermatol 2010; 130 (2): 529-40.
12. Miura K, Yoshiura K, Miura S, et al. A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland. Hum Genet 2007; 121: 631-3. (Pubitemid 46706074)
13. Nakano M, Miwa N, Hirano A, et al. A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene. BMC Genet 2009; 10: 42.
14. Yoshiura K, Kinoshita A, Ishida T, et al. A SNP in the ABCC11 gene is the determinant of human earwax type. Nat Genet 2006; 38: 324-30.
15. Consortium TSSHS. Japanese map of the earwax gene frequency: a nationwide collaborative study by Super Science High School Consortium. J Hum Genet 2009; 54: 499-503.
16. Drury S, Anderson H, Dowsett M. Selection of REFERENCE genes for normalization of qRT-PCR data derived from FFPE breast tumors. Diagn Mol Pathol 2009; 18: 103-7.
17. Penland SK, Keku TO, Torrice C, et al. RNA expression analysis of formalin-fixed paraffin-embedded tumors. Lab Invest 2007; 87: 383-91. (Pubitemid 46474570)
18. Bustin SA, Benes V, Garson JA, et al. The MIQE guidelines: minimum information for publication of quantitative real-time PCR experiments. Clin Chem 2009; 55: 611-22.
19. Park S, Shimizu C, Shimoyama T, et al. Gene expression profiling of ATP-binding cassette (ABC) transporters as a predictor of the pathologic response to neoadjuvant chemotherapy in breast cancer patients. Breast Cancer Res Treat 2006; 99: 9-17. (Pubitemid 44168598)
20. Tammur J, Prades C, Arnould I, et al. Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12. Gene 2001; 273: 89-96. (Pubitemid 32718730)
21. Masri S, Phung S, Wang X, et al. Genome-wide analysis of aromatase inhibitor-resistant, tamoxifen-resistant, and long-term estrogen-deprived cells reveals a role for estrogen receptor. Cancer Res 2008; 68: 4910-8.
22. Russo J, Ao X, Grill C, et al. Pattern of distribution of cells positive for estrogen receptor alpha and progesterone receptor in relation to proliferating cells in the mammary gland. Breast Cancer Res Treat 1999; 53: 217-27. (Pubitemid 29209891)