A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene

BMC Genetics

Volumn 10, Issue , 2009, Pages

  Nakano, Motoi ^a   Miwa, Nobutomo ^a,c   Hirano, Akiyoshi ^a   Yoshiura, Koh Ichiro ^a,c   Niikawa, Norio ^b,c  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b HEALTH SCIENCES UNIVERSITY OF HOKKAIDO   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENINE; GUANINE; PROTEIN ABCC11; UNCLASSIFIED DRUG; ABCC11 PROTEIN, HUMAN;

ANXIETY; APOCRINE GLAND; ARTICLE; AXILLA; AXILLARY OSMIDROSIS; CERUMEN; CLINICAL FEATURE; CONTROLLED STUDY; DIAGNOSTIC VALUE; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC MARKER; GENOTYPE; HUMAN; JAPANESE; MAJOR CLINICAL STUDY; ODOR; SINGLE NUCLEOTIDE POLYMORPHISM; SWEAT GLAND DISEASE; WET EARWAX; ASIAN; GENETICS; METABOLISM; PATHOPHYSIOLOGY; PHENOTYPE;

ASIAN CONTINENTAL ANCESTRY GROUP; ATP-BINDING CASSETTE TRANSPORTERS; AXILLA; CERUMEN; GENE FREQUENCY; GENOTYPE; HUMANS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; SWEAT GLAND DISEASES;

EID: 69349102208     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-10-42     Document Type: Article

References (19)

1. Emter R Natsch A The sequential action of a dipeptidase and a beta-lyase is required for the release of the human body odorant 3-methyl-3-sulfanylhexan-1-ol from a secreted Cys-Gly-(S) conjugate by Corynebacteria J Biol Chem 2008, 283:20645-20652. 10.1074/jbc.M800730200 18515361
2. Matsunaga E The dimorphism in human normal cerumen Ann Hum Genet 1962, 25:273-286. 10.1111/j.1469-1809.1962.tb01766.x 14471313
3. Petrakis NL Molohon KT Tepper DJ Cerumen in American Indians: Genetic implications of sticky and dry types Science 1967, 158:1992-1993. 10.1126/science.158.3805.1192
4. Petrakis NL Pingke U Petrakis SJ Petrakis SL Evidence for a genetic cline in cerumen type in the Middle East and Southeast Asia Am J Phys Anthropol 1971, 35:141-144. 10.1002/ajpa.1330350117 5138849
5. Omoto K Polymorphic traits in peoples of eastern Asia and the Pacific Isr J Med Sci 1973, 9:1195-1215. 4359639
6. Yoshiura K Kinoshita A Ishida T Ninokata A Ishikawa T Kaname T Bannai M Tokunaga K Sonoda S Komaki R Ihara M Saenko VA Alipov GK Sekine I Komatsu K Takahashi H Nakashima M Sosonkina N Mapendano CK Ghadami M Nomura M Liang DS Miwa N Kim DK Garidkhuu A Natsume N Ohta T Tomita H Kaneko A Kikuchi M Russomando G Hirayama K Ishibashi M Takahashi A Saitou N Murray JC Saito S Nakamura Y Niikawa N A SNP in the ABCC11 gene is the determinant of human cerumen type Nature Genet 2006, 38:324-330. 10.1038/ng1733 16444273
7. Meyer zum Gottesberge A Meyer zum Gottesberge AM Cerumen from the anthropologic viewpoint Laryngorhinootologie 1995, 74:50-53. 10.1055/ s-2007-997687 7888024
8. Yabuuchi H Shimizu H Takayanagi S Ishikawa T Multiple splice variants of two human ATP-binding cassette transporters, ABCC11 and ABCC12 Biochem Biophys Res Commun 2001, 288:933-939. 10.1006/bbrc.2001.5865 11688999
9. Tammur J Prades C Arnould I Rzhetsky A Hutchinson A Adachi M Schuetz JD Swoboda KJ Ptacek LJ Rosier M Dean M Allikmets R Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12 tandemly duplicated on chromosome 16q12 Gene 2001, 273:89-96. 10.1016/ S0378-1119(01)00572-8 11483364
10. Bera TK Lee S Salvatore G Lee B Pastan I MRP8, a new member of ABC transporter superfamily, identified by EST database mining and gene prediction program, is highly expressed in breast cancer Mol Med 2001, 7:509-516. 1950066 11591886
11. Kruh GD Belinsky MG The MRP family of drug efflux pumps Oncogene 2003, 22:7537-7552. 10.1038/sj.onc.1206953 14576857
12. Chen ZS Guo Y Belinsky MG Kotova E Kruh GD Transport of bile acids, sulfated steroids, estradiol 17-β-D-glucuronide, and leukotriene C4 by human multidrug resistance protein 8 (ABCC11) Mol Pharmacol 2005, 67:545-557. 10.1124/mol.104.007138 15537867
13. Bortfeld M Rius M König M Herold-Mende C Nies AT Keppler D Human multidrug resistance protein 8 (MRP8/ABCC11), an apical efflux pump for steroid sulfates, is an axonal protein of the CNS and peripheral nervous system Neuroscience 2006, 137:1247-1257. 10.1016/ j.neuroscience.2005.10.025 16359813
14. Zeng XN Leyden JJ Lawley HJ Sawano K Nohara I Preti G Analysis of characteristic odors from human male axillae J Chem Ecol 1991, 17:1469-1492. 10.1007/BF00983777
15. Natsch A Gfeller H Gygax P Schmid J Acuna G A specific bacterial aminoacylase cleaves odorant precursors secreted in the human axilla J Biol Chem 2003, 278:5718-5727. 10.1074/jbc.M210142200 12468539
16. Natsch A Derrer S Flachsmann F Schmidt J A broad diversity of volatile carboxylic acids, released by a bacterial amynoacylase from axilla secretions, as candidate molecules for the determination of human-body odor type Chem Biodiv 2006, 3:1-20. 10.1002/cbdv.200690015
17. Toyoda Y Sakurai A Mitani Y Nakashima M Yoshiura K Nakagawa H Sakai Y Ota I Lezhava A Hayashizaki Y Niikawa N Ishikawa T Earwax, osmidrosis, and breast cancer: Why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type? FASEB J 2009, 23:2001-2013. 10.1096/fj.09-129098 19383836
18. Wigginton JE Cutler DJ Abecasis GR A note on exact tests of Hardy-Weinberg equilibrium Am J Hum Genet 2005, 76:887-893. 10.1086/ 429864 1199378 15789306
19. Purcell S Neale B Todd-Brown K Thomas L Ferreira MAR Bender D Maller J Sklar P de Bakker PIW Daly MJ Sham PC PLINK: A toolset for whole-genome association and population-based linkage analysis Am J Hum Genet 2007, 81:559-575. 10.1086/519795 1950838 17701901