Decreased expression of interleukin-27 in immune thrombocytopenia

British Journal of Haematology

Volumn 153, Issue 2, 2011, Pages 259-267

  Liu, Xin Guang ^a   Ren, Juan ^a   Yu, Yuan ^a   Sun, Lin ^a   Shi, Yan ^a   Qin, Ping ^a   Yang, Lei ^a   Ma, Shi Hui ^b   Dong, Xiao Yuan ^a   Ma, Dao Xin ^a   Qu, Xun ^a   Guo, Cheng Shan ^c   Chen, Chun Yan ^a   Hou, Ming ^a,d   Peng, Jun ^a,d  

^a SHANDONG UNIVERSITY   (China)

^b INSTITUTE OF HEMATOLOGY AND BLOOD DISEASES HOSPITAL   (China)

^c SHANDONG UNIVERSITY   (China)

^d BEIJING HOSPITAL   (China)

Author keywords

Cytokines; Immune thrombocytopenia; Interleukin 27; T helper 17 cells

Indexed keywords

EPSTEIN BARR VIRUS INDUCED GENE PROTEIN 3; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 27; INTERLEUKIN 27 RECEPTOR; INTERLEUKIN 4; INTERLEUKIN RECEPTOR; MESSENGER RNA; RETINOID RELATED ORPHAN RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REMISSION;

ADOLESCENT; ADULT; AGED; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-4; INTERLEUKINS; MALE; MIDDLE AGED; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, INTERLEUKIN; RNA, MESSENGER;

EID: 79953090461     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2011.08614.x     Document Type: Article

References (44)

1. Andersson, J. (1998) Cytokines in idiopathic thrombocytopenic purpura (ITP). Acta Paediatrica Supplement, 424, 61-64.
2. Awasthi, A., Carrier, Y., Peron, J.P., Bettelli, E., Kamanaka, M., Flavell, R.A., Kuchroo, V.K., Oukka, M., Weiner, H.L., Awasthi, A., Carrier, Y., Peron, J.P., Bettelli, E., Kamanaka, M., Flavell, R.A., Kuchroo, V.K., Oukka, M. & Weiner, H.L. (2007) A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nature Immunology, 8, 1380-1389.
3. Batten, M. & Ghilardi, N. (2007) The biology and therapeutic potential of interleukin 27. Journal of Molecular Medicine, 85, 661-672.
4. Batten, M., Li, J., Yi, S., Kljavin, N.M., Danilenko, D.M., Lucas, S., Lee, J., de Sauvage, F.J. & Ghilardi, N. (2006) Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nature Immunology, 7, 929-936.
5. Berchtold, P. & Wenger, M. (1993) Autoantibodies against platelet glycoproteins in autoimmune thrombocytopenic purpura: their clinical significance and response to treatment. Blood, 81, 1246-1250.
6. Cao, Y., Doodes, P.D., Glant, T.T. & Finnegan, A. (2008) IL-27 induces a Th1 immune response and susceptibility to experimental arthritis. Journal of Immunology, 180, 922-930.
7. Diveu, C., McGeachy, M.J., Boniface, K., Stumhofer, J.S., Sathe, M., Joyce-Shaikh, B., Chen, Y., Tato, C.M., McClanahan, T.K., de Waal Malefyt, R., Hunter, C.A., Cua, D.J. & Kastelein, R.A. (2009) IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. Journal of Immunology, 182, 5748-5756.
8. El-behi, M., Ciric, B., Yu, S., Zhang, G.X., Fitzgerald, D.C. & Rostami, A. (2009) Differential effect of IL-27 on developing versus committed Th17 cells. Journal of Immunology, 183, 4957-4967.
9. Guo, C., Chu, X., Shi, Y., He, W., Li, L., Wang, L., Wang, Y., Peng, J. & Hou, M. (2007) Correction of Th1-dominant cytokine profiles by high-dose dexamethasone in patients with chronic idiopathic thrombocytopenic purpura. Journal of Clinical Immunology, 27, 557-562.
10. Heinrich, P.C., Behrmann, I., Müller-Newen, G., Schaper, F. & Graeve, L. (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochemical Journal, 334, 297-314.
11. Hölscher, C., Hölscher, A., Rückerl, D., Yoshimoto, T., Yoshida, H., Mak, T., Saris, C. & Ehlers, S. (2005) The IL-27 receptor chain WSX-1 differentially regulates antibacterial immunity and survival during experimental tuberculosis. Journal of Immunology, 174, 3534-3544.
12. Honda, K., Nakamura, K., Matsui, N., Takahashi, M., Kitamura, Y., Mizutani, T., Harada, N., Nawata, H., Hamano, S. & Yoshida, H. (2005) T helper 1-inducing property of IL-27/WSX-1 signaling is required for the induction of experimental colitis. Inflammatory Bowel Diseases, 11, 1044-1052.
13. Hou, M., Peng, J., Shi, Y., Zhang, C., Qin, P., Zhao, C., Ji, X., Wang, X. & Zhang, M. (2003) Mycophenolate mofetil (MMF) for the treatment of steroid-resistant idiopathic thrombocytopenic purpura. European Journal of Haematology, 70, 353-357.
14. Ivanov, I.I., McKenzie, B.S., Zhou, L., Tadokoro, C.E., Lepelley, A., Lafaille, J.J., Cua, D.J. & Littman, D.R. (2006) The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell, 126, 1121-1133.
15. Kuwana, M., Kaburaki, J. & Ikeda, Y. (1998) Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura: role in production of anti-platelet autoantibody. Journal of Clinical Investigation, 102, 1393-1402.
16. Langrish, C.L., Chen, Y., Blumenschein, W.M., Mattson, J., Basham, B., Sedgwick, J.D., McClanahan, T., Kastelein, R.A. & Cua, D.J. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. The Journal of Experimental Medicine, 201, 233-240.
17. Lee, Y.K., Turner, H., Maynard, C.L., Oliver, J.R., Chen, D., Elson, C.O. & Weaver, C.T. (2009) Late developmental plasticity in the T helper 17 lineage. Immunity, 30, 92-107.
18. Li, T.T., Zhang, T., Chen, G.M., Zhu, Q.Q., Tao, J.H., Pan, H.F. & Ye, D.Q. (2010) Low Level of Serum Interleukin 27 in Patients With Systemic Lupus Erythematosus. Journal of Investigative Medicine, 58, 737-739.
19. Liu, B., Zhao, H., Poon, M.C., Han, Z., Gu, D., Xu, M., Jia, H., Yang, R. & Han, Z.C. (2007) Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura. European Journal of Haematology, 78, 139-143.
20. Ma, D., Zhu, X., Zhao, P., Zhao, C., Li, X., Zhu, Y., Li, L., Sun, J., Peng, J., Ji, C. & Hou, M. (2008) Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Annals of Hematology, 87, 899-904.
21. Molle, C., Nguyen, M., Flamand, V., Renneson, J., Trottein, F., De Wit, D., Willems, F., Goldman, M. & Goriely, S. (2007) IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. Journal of Immunology, 178, 7607-7615.
22. + T Cells. Journal of Immunology, 183, 2435-2443.
23. Niedbala, W., Cai, B., Wei, X., Patakas, A., Leung, B.P., McInnes, I.B. & Liew, F.Y. (2008) Interleukin 27 attenuates collagen-induced arthritis. Annals of the Rheumatic Diseases, 67, 1474-1479.
24. Olsson, B., Andersson, P.O., Jernas, M., Jacobsson, S., Carlsson, B., Carlsson, L.M. & Wadenvik, H. (2003) T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Nature Medicine, 9, 1123-1124.
25. Owaki, T., Asakawa, M., Morishima, N., Hata, K., Fukai, F., Matsui, M., Mizuguchi, J. & Yoshimoto, T. (2005) A role for IL-27 in early regulation of Th1 differentiation. Journal of Immunology, 175, 2191-2200.
26. Panitsas, F.P., Theodoropoulou, M., Kouraklis, A., Karakantza, M., Theodorou, G.L., Zoumbos, N.C., Maniatis, A. & Mouzaki, A. (2004) Adult chronic idiopathic thrombocytopenic purpura (ITP) is the manifestation of a type-1 polarized immune response. Blood, 103, 2645-2647.
27. Pernis, A.B. (2009) Th17 cells in rheumatoid arthritis and systemic lupus erythematosus. Journal of Internal Medicine, 265, 644-652.
28. Pfaffl, M.W., Horgan, G.W. & Dempfle, L. (2002) Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Research, 30, e36.
29. Pflanz, S., Timans, J.C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Churakova, T., Travis, M., Vaisberg, E., Blumenschein, W.M., Mattson, J.D., Wagner, J.L., To, W., Zurawski, S., McClanahan, T.K., Gorman, D.M., Bazan, J.F., de Waal Malefyt, R., Rennick, D. & Kastelein, R.A. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity, 16, 779-790.
30. Pflanz, S., Hibbert, L., Mattson, J., Rosales, R., Vaisberg, E., Bazan, J.F., Phillips, J.H., McClanahan, T.K., de Waal, Malefyt.R. & Kastelein, R.A. (2004) WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. Journal of Immunology, 172, 2225-2231.
31. Provan, D., Stasi, R., Newland, A.C., Blanchette, V.S., Bolton-Maggs, P., Bussel, J.B., Chong, B.H., Cines, D.B., Gernsheimer, T.B., Godeau, B., Grainger, J., Greer, I., Hunt, B.J., Imbach, P.A., Lyons, G., McMillan, R., Rodeghiero, F., Sanz, M.A., Tarantino, M., Watson, S., Young, J. & Kuter, D.J. (2010) International consensus report on the investigation and management of primary immune thrombocytopenia. Blood, 115, 168-186.
32. Schmidt, C., Giese, T., Ludwig, B., Mueller-Molaian, I., Marth, T., Zeuzem, S., Meuer, S.C. & Stallmach, A. (2005) Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis. Inflammatory Bowel Diseases, 11, 16-23.
33. Semple, J.W., Milev, Y., Cosgrave, D., Mody, M., Hornstein, A., Blanchette, V. & Freedman, J. (1996) Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood, 87, 4245-4254.
34. Shibata, S., Tada, Y., Kanda, N., Nashiro, K., Kamata, M., Karakawa, M., Miyagaki, T., Kai, H., Saeki, H., Shirakata, Y., Watanabe, S., Tamaki, K. & Sato, S. (2010) Possible roles of IL-27 in the pathogenesis of psoriasis. The Journal of Investigative Dermatology, 130, 1034-1039.
35. Sprecher, C.A., Grant, F.J., Baumgartner, J.W., Presnell, S.R., Schrader, S.K., Yamagiwa, T., Whitmore, T.E., O'Hara, P.J. & Foster, D.F. (1998) Cloning and characterization of a novel class I cytokine receptor. Biochemical and Biophysical Research Communications, 246, 82-90.
36. Stumhofer, J.S., Laurence, A., Wilson, E.H., Huang, E., Tato, C.M., Johnson, L.M., Villarino, A.V., Huang, Q., Yoshimura, A., Sehy, D., Saris, C.J., O'Shea, J.J., Hennighausen, L., Ernst, M.&. & Hunter, C.A. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nature Immunology, 7, 937-945.
37. Takeda, A., Hamano, S., Yamanaka, A., Hanada, T., Ishibashi, T., Mak, T.W., Yoshimura, A. & Yoshida, H. (2003) Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. Journal of Immunology, 170, 4886-4890.
38. Villarino, A.V., Larkin, III, J., Saris, C.J., Caton, A.J., Lucas, S., Wong, T., de Sauvage, F.J. & Hunter, C.A. (2005) Positive and negative regulation of the IL-27 receptor during lymphoid cell activation. Journal of Immunology, 174, 7684-7691.
39. Wirtz, S., Becker, C., Fantini, M.C., Nieuwenhuis, E.E., Tubbe, I., Galle, P.R., Schild, H.G., Birkenbach, M., Blumberg, R.S. & Neurath, M.F. (2005) EBV-induced gene 3 transcription is induced by TLR signaling in primary dendritic cells via NF-kappa B activation. Journal of Immunology, 174, 2814-2824.
40. Wong, C.K., Chen, da.P., Tam, L.S., Li, E.K., Yin, Y.B. & Lam, C.W. (2010) Effects of inflammatory cytokine IL-27 on the activation of fibroblast-like synoviocytes in rheumatoid arthritis. Arthritis Research and Therapy, 12, R129.
41. Yang, X.O., Pappu, B.P., Nurieva, R., Akimzhanov, A., Kang, H.S., Chung, Y., Ma, L., Shah, B., Panopoulos, A.D., Schluns, K.S., Watowich, S.S., Tian, Q., Jetten, A.M. & Dong, C. (2008) T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity, 28, 29-39.
42. + T cells partially through STAT3-dependent mechanism. Journal of Immunology, 177, 5377-5385.
43. Yu, J., Heck, S., Patel, V., Levan, J., Yu, Y., Bussel, J.B. & Yazdanbakhsh, K. (2008) Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura. Blood, 112, 1325-1328.
44. Zhang, J., Ma, D., Zhu, X., Qu, X., Ji, C. & Hou, M. (2009) Elevated profile of Th17, Th1 and Tc1 cells in patients with immune thrombocytopenic purpura. T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura. Haematologica, 94, 1326-1329.