Visceral hypersensitivity in irritable bowel syndrome

Journal of Gastroenterology and Hepatology (Australia)

Volumn 26, Issue SUPPL. 3, 2011, Pages 119-121

  Kanazawa, Motoyori ^a   Hongo, Michio ^b   Fukudo, Shin ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Brain gut interaction; Inflammation; Irritable bowel syndrome (IBS); Stress; Visceral hypersensitivity

Indexed keywords

ALOSETRON; AMITRIPTYLINE; CORTICOTROPIN RELEASING FACTOR; PROTEINASE ACTIVATED RECEPTOR 2; RAMOSETRON; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR;

ABDOMINAL PAIN; BRAIN REGION; COLON DILATATION; CONFERENCE PAPER; CONSTIPATION; DIARRHEA; HUMAN; HYPNOSIS; IRRITABLE COLON; NOCICEPTION; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PRIORITY JOURNAL; SENSATION; VISCERAL PAIN HYPERSENSITIVITY; VISCERAL SENSATION;

EID: 79953068140     PISSN: 08159319     EISSN: 14401746     Source Type: Journal    
DOI: 10.1111/j.1440-1746.2011.06640.x     Document Type: Conference Paper

References (21)

1. Drossman DA, Camilleri M, Mayer EA, Whitehead WE. AGA technical review on irritable bowel syndrome. Gastroenterology 2002; 123: 2108-31.
2. Azpiroz F, Bouin M, Camilleri M etal. Mechanisms of hypersensitivity in IBS and functional disorders. Neurogastroenterol. Motil. 2007; 19 (Suppl.): 62-88.
3. Whitehead WE, Delvaux M, Azpiroz F etal. Standardization of barostat procedures for testing smooth muscle tone and sensory thresholds in the gastrointestinal tract. Dig. Dis. Sci. 1997; 42: 223-41.
4. Bouin M, Plourde V, Boivin M etal. Rectal distention testing in patients with irritable bowel syndrome: sensitivity, specificity, and predictive values of pain sensory thresholds. Gastroenterology 2002; 122: 1771-7.
5. Kanazawa M, Palsson OS, Thiwan SIM etal. Contributions of pain sensitivity and colonic motility to IBS symptom severity and predominant bowel habits. Am. J. Gastroenterol. 2008; 103: 2550-61.
6. Dorn SD, Palsson OS, Thiwan SI etal. Increased colonic pain sensitivity in irritable bowel syndrome is the result of an increased tendency to report pain rather than increased neurosensory sensitivity. Gut 2007; 56: 1202-9.
7. Mertz H, Morgan V, Tanner G etal. Regional cerebral activation in irritable bowel syndrome and control subjects with painful and nonpainful rectal distension. Gastroenterology 2000; 118: 842-8.
8. Murray CD, Flynn J, Ratcliffe L, Jacyna MR, Kamm MA, Emmanuel AV. Effect of acute physical and psychological stress on gut autonomic innervation in irritable bowel syndrome. Gastroenterology 2004; 127: 1695-703.
9. Dunckley P, Aziz Q, Wise RG, Brooks J, Tracey I, Chang L. Attentional modulation of visceral and somatic pain. Neurogastroenterol. Motil. 2007; 19: 569-77.
10. Chung EK, Zhang X, Li Z, Zhang H, Xu H, Bian Z. Neonatal maternal separation enhances central sensitivity to noxious colorectal distention in rat. Brain Res. 2007; 1153: 68-77.
11. Lea R, Houghton LA, Calvert EL etal. Gut-focused hypnotherapy normalizes disordered rectal sensitivity in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther. 2003; 17: 635-42.
12. Morgan V, Pickens D, Gautam S, Kessler R, Mertz H. Amitriptyline reduces rectal pain related activation of the anterior cingulate cortex in patients with irritable bowel syndrome. Gut 2005; 54: 601-7.
13. Taché Y, Martinez V, Wang L, Million M. CRF1 receptor signaling pathways involved in stress-related alterations of colonic function and viscerosensitivity: implications for irritable bowel syndrome. Br. J. Pharmacol. 2004; 141: 1321-30.
14. Sagami Y, Shimada Y, Tayama J etal. Effect of a corticotropin releasing hormone receptor antagonist on colonic sensory and motor function in patients with irritable bowel syndrome. Gut 2004; 53: 958-64.
15. Spiller RC, Jenkins D, Thornley JP etal. Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute campylobacter enteritis and in post-dysenteric irritable bowel syndrome. Gut 2000; 47: 804-11.
16. Gwee KA, Leong YL, Graham C etal. The role of psychological and biological factors in postinfective gut dysfunction. Gut 1999; 44: 400-6.
17. Barbara G, Stanghellini V, De Giorgio R etal. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126: 693-702.
18. Gershon MD, Tack J. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology 2007; 132: 397-414.
19. Delvaux M, Louvel D, Mamet JP, Campos-Oriola R, Frexinos J. Effect of alosetron on responses to colonic distension in patients with irritable bowel syndrome. Aliment. Pharmacol. Ther. 1998; 12: 849-55.
20. Matsueda K, Harasawa S, Hongo M, Hiwatashi N, Sasaki D. A randomized, double-blind, placebo-controlled clinical trial of the effectiveness of the novel serotonin type 3 receptor antagonist ramosetron in both male and female Japanese patients with diarrhea-predominant irritable bowel syndrome. Scand. J. Gastroenterol. 2008; 43: 1202-11.
21. Gecse K, Róka R, Ferrier L etal. Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity. Gut 2008; 57: 591-9.