High-yield continuous production of nicotinic acid via nitrile hydratase-amidase cascade reactions using cascade CSMRs

Enzyme and Microbial Technology

Volumn 48, Issue 4-5, 2011, Pages 345-350

  Cantarella, L ^b   Gallifuoco, A ^a   Malandra, A ^a   Martinkova L ^c   Spera, A ^a   Cantarella, M ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b UNIVERSITY OF CASSINO AND SOUTHERN LAZIO   (Italy)

^c INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

3 Cyanopyridine bioconversion; Nicotinic acid; Nitrile hydratase amidase cascade system; Series arranged continuous stirred membrane reactor

Indexed keywords

3-CYANOPYRIDINE; 3-CYANOPYRIDINE BIOCONVERSIONS; AMIDASE; CASCADE REACTIONS; CASCADE SYSTEMS; CONTINUOUS PRODUCTION; HIGH YIELD; HIGHER TEMPERATURES; IN-SITU; LOW TEMPERATURES; MEMBRANE BIOREACTOR; MICROBACTERIUM IMPERIALE; NICOTINIC ACID; NITRILE HYDRATASE-AMIDASE CASCADE SYSTEMS; NITRILE HYDRATASES; OPERATIONAL CONDITIONS; REACTOR CONFIGURATION; RESIDENCE TIME; SERIES ARRANGED CONTINUOUS STIRRED MEMBRANE REACTOR; STIRRED TANK; SUBSTRATE CONCENTRATIONS; SUBSTRATE INHIBITION; TEMPERATURE DEPENDENCE;

BIOCONVERSION; BIOREACTORS; ENZYMES; OPTIMIZATION; REACTION RATES; SUBSTRATES;

CYANIDES;

AMIDASE; NICOTINAMIDE; NICOTINIC ACID; NICOTINONITRILE; NITRILE HYDRATASE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM; BIOREACTOR; BIOTRANSFORMATION; CONCENTRATION (PARAMETERS); CONTINUOUSLY STIRRED TANK UF MEMBRANE BIOREACTOR; ENZYME ACTIVATION; MICROBACTERIUM IMPERIALE; PURIFICATION; STEADY STATE; TEMPERATURE SENSITIVITY;

ACTINOMYCETALES; AMIDOHYDROLASES; BIOREACTORS; BIOTECHNOLOGY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CULTURE MEDIA; HOT TEMPERATURE; HYDRO-LYASES; KINETICS; NIACIN; PYRIDINES; TEMPERATURE;

MICROBACTERIUM IMPERIALE;

EID: 79953040906     PISSN: 01410229     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2010.12.010     Document Type: Article

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