Early divergent host responses in SHIVsf162p3 and SIVmac251 infected macaques correlate with control of viremia

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Xu, Huanbin ^a   Wang, Xiaolei ^a   Morici, Lisa A ^b   Pahar, Bapi ^a   Veazey, Ronald S ^a  

^a TULANE NATIONAL PRIMATE RESEARCH CENTER   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA; HLA DR ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RESPONSE; CYTOKINE STORM; DISEASE COURSE; IMMUNE RESPONSE; IMMUNOMODULATION; INFECTION CONTROL; LENTIVIRUS INFECTION; LYMPHOCYTE PROLIFERATION; NONHUMAN; PERSISTENT VIRUS INFECTION; RHESUS MONKEY; SIMIAN HUMAN IMMUNODEFICIENCY VIRUS INFECTION; SIMIAN IMMUNODEFICIENCY VIRUS INFECTION; T LYMPHOCYTE ACTIVATION; VIRAL CLEARANCE; VIRUS CONCENTRATION; VIRUS LOAD; VIRUS REPLICATION; VIRUS VIRULENCE; ANIMAL; BLOOD; CELL PROLIFERATION; HOST PATHOGEN INTERACTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBPOPULATION; MACACA; PATHOLOGY; PHYSIOLOGY; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIREMIA; VIROLOGY;

MACACA; SIMIAN IMMUNODEFICIENCY VIRUS;

ANIMALS; CELL PROLIFERATION; CHEMOKINES; HIV; HLA-DR ANTIGENS; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; LYMPHOCYTE SUBSETS; MACACA; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS; VIREMIA; VIRUS REPLICATION;

EID: 79953038896     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017965     Document Type: Article

References (23)

1. Harouse JM, Gettie A, Eshetu T, Tan RC, Bohm R, et al. (2001) Mucosal transmission and induction of simian AIDS by CCR5-specific simian/human immunodeficiency virus SHIV(SF162P3). J Virol 75: 1990-1995.
2. Pahar B, Piatak M Jr, Lifson JD, Lackner AA, Wang X, et al. (2009 (in press)) Control of viremia and maintenance of intestinal CD4+ memory T cells in SHIV162P3 infected macaques after pathogenic SIVMAC251 challe. Virology.
3. Harouse JM, Gettie A, Tan RC, Blanchard J, Cheng-Mayer C, (1999) Distinct pathogenic sequela in rhesus macaques infected with CCR5 or CXCR4 utilizing SHIVs. Science 284: 816-819.
4. Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, et al. (2004) Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 200: 761-770.
5. Veazey RS, DeMaria M, Chalifoux LV, Shvetz DE, Pauley DR, et al. (1998) Gastrointestinal tract as a major site of CD4+ T cell depletion and viral replication in SIV infection. Science 280: 427-431.
6. Pandrea I, Apetrei C, Gordon S, Barbercheck J, Dufour J, et al. (2007) Paucity of CD4+CCR5+ T cells is a typical feature of natural SIV hosts. Blood 109: 1069-1076.
7. Sodora DL, Allan JS, Apetrei C, Brenchley JM, Douek DC, et al. (2009) Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts. Nat Med 15: 861-865.
8. Manches O, Bhardwaj N, (2009) Resolution of immune activation defines nonpathogenic SIV infection. J Clin Invest 119: 3512-3515.
9. Paiardini M, Cervasi B, Engram JC, Gordon SN, Klatt NR, et al. (2009) Bone marrow-based homeostatic proliferation of mature T cells in nonhuman primates: implications for AIDS pathogenesis. Blood 113: 612-621.
10. Silvestri G, Paiardini M, Pandrea I, Lederman MM, Sodora DL, (2007) Understanding the benign nature of SIV infection in natural hosts. J Clin Invest 117: 3148-3154.
11. Kornfeld C, Ploquin MJ, Pandrea I, Faye A, Onanga R, et al. (2005) Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS. J Clin Invest 115: 1082-1091.
12. Zou W, Dulioust A, Fior R, Durand-Gasselin J, Boue F, et al. (1997) Increased T-helper-type 2 cytokine production in chronic HIV infection is due to interleukin (IL)-13 rather than IL-4. AIDS 11: 533-555.
13. Veazey R, Lackner A, (2003) The mucosal immune system and HIV-1 infection. AIDS Rev 5: 245-252.
14. Pahar B, Lackner AA, Piatak M Jr, Lifson JD, Wang X, et al. (2009) Control of viremia and maintenance of intestinal CD4(+) memory T cells in SHIV(162P3) infected macaques after pathogenic SIV(MAC251) challenge. Virology 387: 273-284.
15. Bessis AS, Vadesne G, Bourrat E, Bertho G, Pin JP, et al. (2003) 3-carboxy-4-phosphonocyclopentane amino acids: new metabotropic glutamate receptor ligands. Amino Acids 24: 303-310.
16. Veazey RS, Klasse PJ, Ketas TJ, Reeves JD, Piatak M Jr, et al. (2003) Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection. J Exp Med 198: 1551-1562.
17. Meythaler M, Martinot A, Wang Z, Pryputniewicz S, Kasheta M, et al. (2009) Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection. J Virol 83: 572-583.
18. Cumont MC, Diop O, Vaslin B, Elbim C, Viollet L, et al. (2008) Early divergence in lymphoid tissue apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates. J Virol 82: 1175-1184.
19. Kaur A, Di Mascio M, Barabasz A, Rosenzweig M, McClure HM, et al. (2008) Dynamics of T- and B-lymphocyte turnover in a natural host of simian immunodeficiency virus. J Virol 82: 1084-1093.
20. McMichael AJ, Borrow P, Tomaras GD, Goonetilleke N, Haynes BF, (2010) The immune response during acute HIV-1 infection: clues for vaccine development. Nat Rev Immunol 10: 11-23.
21. Bangs SC, Baban D, Cattan HJ, Li CK, McMichael AJ, et al. (2009) Human CD4+ memory T cells are preferential targets for bystander activation and apoptosis. J Immunol 182: 1962-1971.
22. Letvin NL, Mascola JR, Sun Y, Gorgone DA, Buzby AP, et al. (2006) Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science 312: 1530-1533.
23. Gea-Banacloche JC, Migueles SA, Martino L, Shupert WL, McNeil AC, et al. (2000) Maintenance of large numbers of virus-specific CD8+ T cells in HIV-infected progressors and long-term nonprogressors. J Immunol 165: 1082-1092.