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Volumn 6, Issue 4, 2011, Pages 661-670

The human immunodeficiency virus protease inhibitor ritonavir inhibits lung cancer cells, in part, by inhibition of survivin

Author keywords

Chemotherapy; Non small cell lung cancer; Ritonavir; Survivin

Indexed keywords

CISPLATIN; CYCLIN D1; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE 6; CYCLIN DEPENDENT KINASE INHIBITOR 1B; GEMCITABINE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; K RAS PROTEIN; MESSENGER RNA; PROTEIN P53; RITONAVIR; RNA; STAT3 PROTEIN; SURVIVIN;

EID: 79953025303     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e31820c9e3c     Document Type: Article
Times cited : (38)

References (60)
  • 2
    • 5644244886 scopus 로고    scopus 로고
    • HIV-1 protease inhibitor, ritonavir: A potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo
    • DOI 10.1158/0008-5472.CAN-03-2677
    • Ikezoe T, Hisatake Y, Takeuchi T, et al. HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo. Cancer Res 2004;64:7426-7431. (Pubitemid 39372084)
    • (2004) Cancer Research , vol.64 , Issue.20 , pp. 7426-7431
    • Ikezoe, T.1    Hisatake, Y.2    Takeuchi, T.3    Ohtsuki, Y.4    Yang, Y.5    Said, J.W.6    Taguchi, H.7    Koeffler, H.P.8
  • 3
    • 33645693857 scopus 로고    scopus 로고
    • Effects ofHIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer
    • Srirangam A, Mitra R, Wang M, et al. Effects ofHIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer. Clin Can-cer Res 2006;12:1883-1896.
    • (2006) Clin Can-cer Res , vol.12 , pp. 1883-1896
    • Srirangam, A.1    Mitra, R.2    Wang, M.3
  • 4
    • 67549134670 scopus 로고    scopus 로고
    • Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells
    • Kumar S, Bryant CS, Chamala S, et al. Ritonavir blocks AKT signaling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells. Mol Cancer 2009;8:26.
    • (2009) Mol Cancer , vol.8 , pp. 26
    • Kumar, S.1    Bryant, C.S.2    Chamala, S.3
  • 5
    • 0037093067 scopus 로고    scopus 로고
    • Antitumorigenic effects of HIV protease inhibitor ritonavir: Inhibition of kaposi sarcoma
    • DOI 10.1182/blood.V99.10.3771
    • Pati S, Pelser CB, Dufraine J, et al. Antitumorigenic effects of HIV protease inhibitor ritonavir: inhibition of Kaposi sarcoma. Blood 2002; 99:3771-3779. (Pubitemid 34534550)
    • (2002) Blood , vol.99 , Issue.10 , pp. 3771-3779
    • Pati, S.1    Pelser, C.B.2    Dufraine, J.3    Bryant, J.L.4    Reitz Jr., M.S.5    Weichold, F.F.6
  • 8
    • 33747161036 scopus 로고    scopus 로고
    • Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer
    • DOI 10.1002/cncr.22044
    • Ai Z, Yin L, Zhou X, et al. Inhibition of survivin reduces cell prolifer-ation and induces apoptosis in human endometrial cancer. Cancer 2006;107:746-756. (Pubitemid 44232667)
    • (2006) Cancer , vol.107 , Issue.4 , pp. 746-756
    • Ai, Z.1    Yin, L.2    Zhou, X.3    Zhu, Y.4    Zhu, D.5    Yu, Y.6    Feng, Y.7
  • 9
    • 19344374856 scopus 로고    scopus 로고
    • Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion
    • DOI 10.1016/j.immuni.2005.03.012, PII S107476130500107X
    • Song J, So T, Cheng M, et al. Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. Immunity 2005;22: 621-631. (Pubitemid 40719197)
    • (2005) Immunity , vol.22 , Issue.5 , pp. 621-631
    • Song, J.1    So, T.2    Cheng, M.3    Tang, X.4    Croft, M.5
  • 10
    • 0036785405 scopus 로고    scopus 로고
    • The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34(+) cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells
    • Fukuda S, Foster RG, Porter SB, et al. The antiapoptosis protein survivin is associated with cell cycle entry of normal cord blood CD34(+) cells and modulates cell cycle and proliferation of mouse hematopoietic progenitor cells. Blood 2002;100:2463-2471.
    • (2002) Blood , vol.100 , pp. 2463-2471
    • Fukuda, S.1    Foster, R.G.2    Porter, S.B.3
  • 11
    • 0034612594 scopus 로고    scopus 로고
    • Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/Cyclin E complex activation
    • Suzuki A, Hayashida M, Ito T, et al. Survivin initiates cell cycle entry by the competitive interaction with Cdk4/p16(INK4a) and Cdk2/cyclin E complex activation. Oncogene 2000;19:3225-3234. (Pubitemid 30487409)
    • (2000) Oncogene , vol.19 , Issue.29 , pp. 3225-3234
    • Suzuki, A.1    Hayashida, M.2    Ito, T.3    Kawano, H.4    Nakano, T.5    Miura, M.6    Akahane, K.7    Shiraki, K.8
  • 12
    • 0034532701 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner
    • Zhao J, Tenev T, Martins LM, et al. The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner. J Cell Sci 2000;113:4363-4371. (Pubitemid 32000697)
    • (2000) Journal of Cell Science , vol.113 , Issue.23 , pp. 4363-4371
    • Zhao, J.1    Tenev, T.2    Martins, L.M.3    Downward, J.4    Lemoine, N.R.5
  • 13
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    • DOI 10.1038/nm0897-917
    • Ambrosini G, Adida C, Altieri DC A novel anti-apoptosis gene, sur-vivin, expressed in cancer and lymphoma. Nat Med 1997;3:917-921. (Pubitemid 27353455)
    • (1997) Nature Medicine , vol.3 , Issue.8 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 15
    • 37549036729 scopus 로고    scopus 로고
    • Cancer networks and pathway-directed drug dis-covery
    • Altieri DC Survivin, cancer networks and pathway-directed drug dis-covery. Nat Rev Cancer 2008;8:61-70.
    • (2008) Nat Rev Cancer , vol.8 , pp. 61-70
    • Altieri, D.C.1    Survivin2
  • 16
    • 24744444762 scopus 로고    scopus 로고
    • The use of antisense oligonucleotides in evaluating survivin as a therapeutic target for radiation sensitization in lung cancer
    • DOI 10.1251/bpo95
    • Shinohara ET, Hallahan DE, Lu B. The use of antisense oligonucleotides in evaluating survivin as a therapeutic target for radiation sensitization in lung cancer. Biol Proced Online 2004;6:250-256. (Pubitemid 41358141)
    • (2004) Biological Procedures Online , vol.6 , Issue.1 , pp. 250-256
    • Shinohara, E.T.1    Hallahan, D.E.2    Lu, B.3
  • 19
    • 37649020907 scopus 로고    scopus 로고
    • Survivin gene RNA interference inhibits proliferation, induces apoptosis, and enhances radiosensitivity in HeLa cells
    • Song H, Xin XY, Xiao F, et al. Survivin gene RNA interference inhibits proliferation, induces apoptosis, and enhances radiosensitivity in HeLa cells. Eur J Obstet Gynecol Reprod Biol 2008;136:83-89.
    • (2008) Eur J Obstet Gynecol Reprod Biol , vol.136 , pp. 83-89
    • Song, H.1    Xin, X.Y.2    Xiao, F.3
  • 21
    • 33745283242 scopus 로고    scopus 로고
    • Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy
    • Schimmer AD, Dalili S. Targeting the IAP family of caspase inhibitors as an emerging therapeutic strategy. Hematology Am Soc Hematol Educ Program 2005;215-219.
    • (2005) Hematology Am Soc Hematol Educ Program , pp. 215-219
    • Schimmer, A.D.1    Dalili, S.2
  • 22
    • 70350234507 scopus 로고    scopus 로고
    • Survivin: A new target for anti-cancer therapy
    • Ryan BM, O'Donovan N, Duffy MJ. Survivin: a new target for anti-cancer therapy. Cancer Treat Rev 2009;35:553-562.
    • (2009) Cancer Treat Rev , vol.35 , pp. 553-562
    • Ryan, B.M.1    O'Donovan, N.2    Duffy, M.J.3
  • 25
    • 45649083757 scopus 로고    scopus 로고
    • The role of survivin on overall survival of non-small cell lung cancer, a meta-analysis of published literatures
    • Fan J, Wang L, Jiang GN, et al. The role of survivin on overall survival of non-small cell lung cancer, a meta-analysis of published literatures. Lung Cancer 2008;61:91-96.
    • (2008) Lung Cancer , vol.61 , pp. 91-96
    • Fan, J.1    Wang, L.2    Jiang, G.N.3
  • 26
    • 33646598093 scopus 로고    scopus 로고
    • Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin
    • Dasgupta P, Kinkade R, Joshi B, et al. Nicotine inhibits apoptosis induced by chemotherapeutic drugs by up-regulating XIAP and survivin. Proc Natl Acad Sci USA 2006;103:6332-6337.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 6332-6337
    • Dasgupta, P.1    Kinkade, R.2    Joshi, B.3
  • 27
    • 33750571170 scopus 로고    scopus 로고
    • Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib
    • DOI 10.1158/0008-5472.CAN-06-1684
    • Morgillo F, Woo JK, Kim ES, et al. Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib. Cancer Res 2006;66:10100-10111. (Pubitemid 44672064)
    • (2006) Cancer Research , vol.66 , Issue.20 , pp. 10100-10111
    • Morgillo, F.1    Woo, J.K.2    Kim, E.S.3    Hong, W.K.4    Lee, H.-Y.5
  • 28
    • 34249049000 scopus 로고    scopus 로고
    • Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib
    • DOI 10.1158/1078-0432.CCR-06-2077
    • Morgillo F, Kim WY, Kim ES, et al. Implication of the insulin-like growth factor-IR pathway in the resistance of non-small cell lung cancer cells to treatment with gefitinib. Clin Cancer Res 2007;13:2795-2803. (Pubitemid 46788049)
    • (2007) Clinical Cancer Research , vol.13 , Issue.9 , pp. 2795-2803
    • Morgillo, F.1    Kim, W.-Y.2    Kim, E.S.3    Ciardiello, F.4    Waun, K.H.5    Lee, H.-Y.6
  • 31
    • 0026611149 scopus 로고
    • Expression of pp60c-src in human small cell and non-small cell lung carcinomas
    • Mazurenko NN, Kogan EA, Zborovskaya IB, et al. Expression of pp60c-src in human small cell and non-small cell lung carcinomas. Eur J Cancer 1992;28:372-377.
    • (1992) Eur J Cancer , vol.28 , pp. 372-377
    • Mazurenko, N.N.1    Kogan, E.A.2    Zborovskaya, I.B.3
  • 32
    • 0037699512 scopus 로고    scopus 로고
    • Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells
    • DOI 10.1038/sj.onc.1206479
    • Song L, Turkson J, Karras JG, et al. Activation of Stat3 by receptor tyrosine kinases and cytokines regulates survival in human non-small cell carcinoma cells. Oncogene 2003;22:4150-4165. (Pubitemid 36876236)
    • (2003) Oncogene , vol.22 , Issue.27 , pp. 4150-4165
    • Song, L.1    Turkson, J.2    Karras, J.G.3    Jove, R.4    Haura, E.B.5
  • 36
    • 45749106028 scopus 로고    scopus 로고
    • Phase i trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemo-radiation for locally advanced pancreatic cancer
    • Brunner TB, Geiger M, Grabenbauer GG, et al. Phase I trial of the human immunodeficiency virus protease inhibitor nelfinavir and chemo-radiation for locally advanced pancreatic cancer. J Clin Oncol 2008;26: 2699-2706.
    • (2008) J Clin Oncol , vol.26 , pp. 2699-2706
    • Brunner, T.B.1    Geiger, M.2    Grabenbauer, G.G.3
  • 37
    • 78149359459 scopus 로고    scopus 로고
    • Long-term survival following metachronous intratumoral hemorrhage in an HIV-infected patient with lung cancer
    • Okuma Y, Hosomi Y, Takagi Y, et al. Long-term survival following metachronous intratumoral hemorrhage in an HIV-infected patient with lung cancer. Int J Clin Oncol 2010;15:515-518.
    • (2010) Int J Clin Oncol , vol.15 , pp. 515-518
    • Okuma, Y.1    Hosomi, Y.2    Takagi, Y.3
  • 38
    • 67650531172 scopus 로고    scopus 로고
    • Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response
    • Zhang YW, Jones TL, Martin SE, et al. Implication of checkpoint kinase-dependent up-regulation of ribonucleotide reductase R2 in DNA damage response. J Biol Chem 2009;284:18085-18095.
    • (2009) J Biol Chem , vol.284 , pp. 18085-18095
    • Zhang, Y.W.1    Jones, T.L.2    Martin, S.E.3
  • 39
    • 0030895312 scopus 로고    scopus 로고
    • Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations
    • Barry M, Gibbons S, Back D, et al. Protease inhibitors in patients with HIV disease. Clinically important pharmacokinetic considerations. Clin Pharmacokinet 1997;32:194-209. (Pubitemid 27122520)
    • (1997) Clinical Pharmacokinetics , vol.32 , Issue.3 , pp. 194-209
    • Barry, M.1    Gibbons, S.2    Back, D.3    Mulcahy, F.4
  • 41
    • 77950979667 scopus 로고    scopus 로고
    • Interactions between cytotoxic chemotherapy and antiretroviral treatment in human immunodeficiency virus-infected patients with lung cancer
    • Makinson A, Pujol JL, Le Moing V, et al. Interactions between cytotoxic chemotherapy and antiretroviral treatment in human immunodeficiency virus-infected patients with lung cancer. J Thorac Oncol;5:562-571.
    • J Thorac Oncol , vol.5 , pp. 562-571
    • Makinson, A.1    Pujol, J.L.2    Le Moing, V.3
  • 42
    • 0021118703 scopus 로고
    • Quantitative analysis of dose-effect relationships: The combined effects of multiple drugs or enzyme inhibitors
    • Chou TC, Talalay P. Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 1984;22:27-55.
    • (1984) Adv Enzyme Regul , vol.22 , pp. 27-55
    • Chou, T.C.1    Talalay, P.2
  • 44
    • 0035690123 scopus 로고    scopus 로고
    • Drug distribution and pharmacokinetic/pharmacodynamic relationship of paclitaxel and gemcitabine in patients with non-small-cell lung cancer
    • DOI 10.1023/A:1013133415945
    • Fogli S, Danesi R, De Braud F, et al. Drug distribution and pharmaco-kinetic/pharmacodynamic relationship of paclitaxel and gemcitabine in patients with non-small-cell lung cancer. Ann Oncol 2001;12:1553-1559. (Pubitemid 34065884)
    • (2001) Annals of Oncology , vol.12 , Issue.11 , pp. 1553-1559
    • Fogli, S.1    Danesi, R.2    Braud, F.D.3    Pas, T.D.4    Curigliano, G.5    Giovannetti, E.6    Tacca, M.D.7
  • 46
    • 79960042770 scopus 로고    scopus 로고
    • Targeted therapy in non-small-cell lung cancer-is it becoming a reality?
    • Janku F, Stewart DJ, Kurzrock R. Targeted therapy in non-small-cell lung cancer-is it becoming a reality? Nat Rev Clin Oncol 2010;7:401-414.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 401-414
    • Janku, F.1    Stewart, D.J.2    Kurzrock, R.3
  • 47
    • 0032732512 scopus 로고    scopus 로고
    • The relationship between ritonavir plasma levels and side-effects: Implications for therapeutic drug monitoring
    • DOI 10.1097/00002030-19991022000011
    • Gatti G, Di Biagio A, Casazza R, et al. The relationship between ritonavir plasma levels and side-effects: implications for therapeutic drug monitoring. Aids 1999;13:2083-2089. (Pubitemid 29509585)
    • (1999) AIDS , vol.13 , Issue.15 , pp. 2083-2089
    • Gatti, G.1    Di Biagio, A.2    Casazza, R.3    De Pascalis, C.4    Bassetti, M.5    Cruciani, M.6    Vella, S.7    Bassetti, D.8
  • 50
    • 34247618922 scopus 로고    scopus 로고
    • Survivin expression in non-small-cell lung carcinomas: Correlation with apoptosis and other apoptosis-related proteins, clinicopathologic prognostic factors and prognosis
    • DOI 10.1097/01.pai.0000201808.35931.78, PII 0012903920070300000004
    • Ulukus EC, Kargi HA, Sis B, et al. Survivin expression in non-small-cell lung carcinomas: correlation with apoptosis and other apoptosis-related proteins, clinicopathologic prognostic factors and prognosis. Appl Im-munohistochem Mol Morphol 2007;15:31-37. (Pubitemid 46673313)
    • (2007) Applied Immunohistochemistry and Molecular Morphology , vol.15 , Issue.1 , pp. 31-37
    • Ulukus, E.C.1    Kargi, H.A.2    Sis, B.3    Lebe, B.4    Oztop, I.5    Akkoclu, A.6    Onen, A.7    Sanli, A.8
  • 51
    • 54249084045 scopus 로고    scopus 로고
    • ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance
    • Ewald B, Sampath D, Plunkett W. ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. Cancer Res 2008;68:7947-7955.
    • (2008) Cancer Res , vol.68 , pp. 7947-7955
    • Ewald, B.1    Sampath, D.2    Plunkett, W.3
  • 54
    • 61449231836 scopus 로고    scopus 로고
    • Survivin may enhance DNA double-strand break repair capability by up-regulating Ku70 in human KB cells
    • Jiang G, Ren B, Xu L, et al. Survivin may enhance DNA double-strand break repair capability by up-regulating Ku70 in human KB cells. Anticancer Res 2009;29:223-228.
    • (2009) Anticancer Res , vol.29 , pp. 223-228
    • Jiang, G.1    Ren, B.2    Xu, L.3
  • 55
    • 33745225169 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair
    • Dantzer F, Ame JC, Schreiber V, et al. Poly(ADP-ribose) polymerase-1 activation during DNA damage and repair. Methods Enzymol 2006;409: 493-510.
    • (2006) Methods Enzymol , vol.409 , pp. 493-510
    • Dantzer, F.1    Ame, J.C.2    Schreiber, V.3
  • 57
    • 34447302016 scopus 로고    scopus 로고
    • Sealing of Chromosomal DNA Nicks during Nucleotide Excision Repair Requires XRCC1 and DNA Ligase IIIα in a Cell-Cycle-Specific Manner
    • DOI 10.1016/j.molcel.2007.06.014, PII S1097276507004042
    • Moser J, Kool H, Giakzidis I, et al. Sealing ofchromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner. Mol Cell 2007;27:311-323. (Pubitemid 47058307)
    • (2007) Molecular Cell , vol.27 , Issue.2 , pp. 311-323
    • Moser, J.1    Kool, H.2    Giakzidis, I.3    Caldecott, K.4    Mullenders, L.H.F.5    Fousteri, M.I.6
  • 58
    • 66649137114 scopus 로고    scopus 로고
    • Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-links
    • Zhu G, Lippard SJ. Photoaffinity labeling reveals nuclear proteins that uniquely recognize cisplatin-DNA interstrand cross-links. Biochemistry 2009;48:4916-4925.
    • (2009) Biochemistry , vol.48 , pp. 4916-4925
    • Zhu, G.1    Lippard, S.J.2
  • 59
    • 59649094883 scopus 로고    scopus 로고
    • Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA
    • Guggenheim ER, Xu D, Zhang CX, et al. Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA. Chembiochem 2009;10:141-157.
    • (2009) Chembiochem , vol.10 , pp. 141-157
    • Guggenheim, E.R.1    Xu, D.2    Zhang, C.X.3
  • 60
    • 77957555168 scopus 로고    scopus 로고
    • Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhi-bition, gemcitabine, and cisplatin
    • Hastak K, Alli E, Ford JM. Synergistic chemosensitivity of triple-negative breast cancer cell lines to poly(ADP-Ribose) polymerase inhi-bition, gemcitabine, and cisplatin. Cancer Res 2010;70:7970-7980.
    • (2010) Cancer Res , vol.70 , pp. 7970-7980
    • Hastak, K.1    Alli, E.2    Ford, J.M.3


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