BeKm-1, a peptide inhibitor of human ether-a-go-go-related gene potassium currents, prolongs QTc intervals in isolated rabbit heart

Journal of Pharmacology and Experimental Therapeutics

Volumn 337, Issue 1, 2011, Pages 2-8

  Qu, Yusheng ^a   Fang, Mei ^a   Gao, BaoXi ^a   Chui, Ray W ^a   Vargas, Hugo M ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; BEKM 1; DOFETILIDE; POLYCLONAL ANTIBODY; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL HERG; POTASSIUM ION; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHANNEL GATING; CONCENTRATION RESPONSE; CONTROLLED STUDY; ELECTROCARDIOGRAPHY; EMBRYO; HEART BEAT; HEART LEFT VENTRICLE CONTRACTILITY; HUMAN; HUMAN CELL; ISOLATED HEART; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION; RABBIT;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; FEMALE; HEART; HEK293 CELLS; HUMANS; LONG QT SYNDROME; PEPTIDES; RABBITS; SCORPION VENOMS;

EID: 79953020046     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.176883     Document Type: Article

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