Assessment of drug-induced QT interval prolongation in conscious rabbits

Journal of Pharmacological and Toxicological Methods

Volumn 53, Issue 2, 2006, Pages 168-173

  Kijtawornrat, A ^a   Ozkanlar, Y ^b   Keene, B W ^c,d   Roche, B M ^c   Hamlin, D M ^c   Hamlin, R L ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b ATATÜRK UNIVERSITY   (Turkey)

^c QTest Laboratories Inc   (United States)

^d NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Conscious; Drug induced QT prolongation; Methods; QTc; Rabbit; Torsadogenic

Indexed keywords

CISAPRIDE; DIMETHYL SULFOXIDE; DOFETILIDE; ENALAPRILAT; HALOPERIDOL; PROPRANOLOL; ZATEBRADINE;

ACCURACY; ALGORITHM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CONSCIOUSNESS; CONTROLLED STUDY; DRUG INDUCED DISEASE; ELECTROCARDIOGRAM; FEMALE; HEART RATE; MALE; NONHUMAN; PREDICTION; QT INTERVAL; QT PROLONGATION; RABBIT; REGRESSION ANALYSIS; RELIABILITY; RR INTERVAL; VALIDATION PROCESS;

ANIMALS; CISAPRIDE; CONSCIOUSNESS; DRUG EVALUATION, PRECLINICAL; ELECTROCARDIOGRAPHY; ENALAPRILAT; FEMALE; HALOPERIDOL; INJECTIONS, INTRAVENOUS; LONG QT SYNDROME; MALE; PHENETHYLAMINES; PROPRANOLOL; RABBITS; REPRODUCIBILITY OF RESULTS; SULFONAMIDES; TOXICITY TESTS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 33644541128     PISSN: 10568719     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vascn.2005.04.013     Document Type: Article

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