Anti-citrullinated protein antibodies in rheumatoid arthritis: A functional role for mast cells and basophils?

Annals of the Rheumatic Diseases

Volumn 70, Issue SUPPL. 1, 2011, Pages

  Suurmond, J ^a   Schuerwegh, A J M ^a   Toes, R E M ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT COMPONENT C3B; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; FC RECEPTOR; IMMUNOGLOBULIN E; CITRULLINATED PROTEIN ANTIBODY; FC EPSILON RECEPTOR I; PROTEIN ANTIBODY; UNCLASSIFIED DRUG; AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE; CYCLOPEPTIDE;

ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ANTIGEN ANTIBODY COMPLEX; ANTIGEN RECOGNITION; AUTOIMMUNE DISEASE; BASOPHIL; CELL FUNCTION; CHRONIC INFLAMMATION; COMPLEMENT ACTIVATION; CONFERENCE PAPER; DISEASE COURSE; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOPATHOGENESIS; MACROPHAGE ACTIVATION; MAST CELL; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; CELL ACTIVATION; DISEASE SEVERITY; IMMUNE RESPONSE; IN VITRO STUDY; MACROPHAGE; PHENOTYPE; PROTEIN CROSS LINKING; RECEPTOR BINDING; SYNOVIOCYTE; IMMUNOLOGY; REVIEW;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; BASOPHILS; HUMANS; IMMUNOGLOBULIN E; MAST CELLS; PEPTIDES, CYCLIC;

EID: 79953005787     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2010.138032     Document Type: Conference Paper

References (32)

1. Gabriel SE. The epidemiology of rheumatoid arthritis. Rheum Dis Clin North Am 2001;27:269-81. (Pubitemid 32488705)
2. Schellekens GA, Visser H, de Jong BA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 2000;43:155-63. (Pubitemid 30368225)
3. Nishimura K, Sugiyama D, Kogata Y, et al. Meta-analysis: diagnostic accuracy of anti-cyclic citrullinated peptide antibody and rheumatoid factor for rheumatoid arthritis. Ann Intern Med 2007;146:797-808. (Pubitemid 351650500)
4. György B, Tóth E, Tarcsa E, et al. Citrullination: a posttranslational modification in health and disease. Int J Biochem Cell Biol 2006;38:1662-77. (Pubitemid 43947646)
5. Makrygiannakis D, af Klint E, Lundberg IE, et al. Citrullination is an inflammation-dependent process. Ann Rheum Dis 2006;65:1219-22.
6. Baeten D, Peene I, Union A, et al. Specific presence of intracellular citrullinated proteins in rheumatoid arthritis synovium: relevance to antifilaggrin autoantibodies. Arthritis Rheum 2001;44:2255-62.
7. Klareskog L, Rönnelid J, Lundberg K, et al. Immunity to citrullinated proteins in rheumatoid arthritis. Annu Rev Immunol 2008;26:651-75. (Pubitemid 351600388)
8. Huizinga TW, Amos CI, van der Helm-van Mil AH, et al. Refining the complex rheumatoid arthritis phenotype based on specificity of the HLA-DRB1 shared epitope for antibodies to citrullinated proteins. Arthritis Rheum 2005;52:3433-8. (Pubitemid 41612209)
9. van der Helm-van Mil AH, Verpoort KN, Breedveld FC, et al. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum 2006;54:1117-21. (Pubitemid 43672924)
10. Verpoort KN, van Gaalen FA, van der Helm-van Mil AH, et al. Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis. Arthritis Rheum 2005;52:3058-62. (Pubitemid 41447086)
11. Klareskog L, Stolt P, Lundberg K, et al. A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 2006;54:38-46. (Pubitemid 43122184)
12. Pedersen M, Jacobsen S, Garred P, et al. Strong combined gene-environment effects in anti-cyclic citrullinated peptide-positive rheumatoid arthritis: a nationwide case-control study in Denmark. Arthritis Rheum 2007;56:1446-53. (Pubitemid 46764072)
13. Meyer O, Labarre C, Dougados M, et al. Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage. Ann Rheum Dis 2003;62:120-6. (Pubitemid 36135386)
14. Rönnelid J, Wick MC, Lampa J, et al. Longitudinal analysis of citrullinated protein/ peptide antibodies (anti-CP) during 5 year follow up in early rheumatoid arthritis: anti-CP status predicts worse disease activity and greater radiological progression. Ann Rheum Dis 2005;64:1744-9. (Pubitemid 41667149)
15. Rantapää-Dahlqvist S, de Jong BA, Berglin E, et al. Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 2003;48:2741-9. (Pubitemid 37280601)
16. Kuhn KA, Kulik L, Tomooka B, et al. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest 2006;116:961-73.
17. Uysal H, Bockermann R, Nandakumar KS, et al. Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis. J Exp Med 2009;206:449-62.
18. Schroeder HW, Jr, Cavacini L. Structure and function of immunoglobulins. J Allergy Clin Immunol 2010;125 ( 2 Suppl 2 ): S41-52.
19. Trouw LA, Haisma EM, Levarht EW, et al. Anti-cyclic citrullinated peptide antibodies from rheumatoid arthritis patients activate complement via both the classical and alternative pathways. Arthritis Rheum 2009;60:1923-31.
20. Verpoort KN, Jol-van der Zijde CM, Papendrecht-van der Voort EA, et al. Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response. Arthritis Rheum 2006;54:3799-808. (Pubitemid 44955880)
21. Clavel C, Nogueira L, Laurent L, et al. Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum 2008;58:678-88. (Pubitemid 351364865)
22. Schuerwegh AJ, Ioan-Facsinay A, Dorjée AL, et al. Evidence for a functional role of IgE anticitrullinated protein antibodies in rheumatoid arthritis. Proc Natl Acad Sci USA 2010;107:2586-91.
23. Crisp AJ, Chapman CM, Kirkham SE, et al. Articular mastocytosis in rheumatoid arthritis. Arthritis Rheum 1984;27:845-51. (Pubitemid 14067778)
24. Malone DG, Irani AM, Schwartz LB, et al. Mast cell numbers and histamine levels in synovial fluids from patients with diverse arthritides. Arthritis Rheum 1986; 29:956-63. (Pubitemid 16049254)
25. Lee DM, Friend DS, Gurish MF, et al. Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 2002;297:1689-92. (Pubitemid 35000781)
26. Galli SJ, Grimbaldeston M, Tsai M. Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol 2008;8:478-86. (Pubitemid 351733419)
27. Perrigoue JG, Saenz SA, Siracusa MC, et al. MHC class II-dependent basophil- CD4+ T cell interactions promote T(H)2 cytokine-dependent immunity. Nat Immunol 2009;10:697-705.
28. Sokol CL, Chu NQ, Yu S, et al. Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response. Nat Immunol 2009;10:713-20.
29. Yoshimoto T, Yasuda K, Tanaka H, et al. Basophils contribute to T(H)2-IgE responses in vivo via IL-4 production and presentation of peptide-MHC class II complexes to CD4+ T cells. Nat Immunol 2009;10:706-12.
30. Gaudenzio N, Espagnolle N, Mars LT, et al. Cell-cell cooperation at the T helper cell/ mast cell immunological synapse. Blood 2009;114:4979-88.
31. Denzel A, Maus UA, Rodriguez Gomez M, et al. Basophils enhance immunological memory responses. Nat Immunol 2008;9:733-42. (Pubitemid 351859156)
32. Merluzzi S, Frossi B, Gri G, et al. Mast cells enhance proliferation of B lymphocytes and drive their differentiation toward IgA-secreting plasma cells. Blood 2010;115:2810-7.