The in-vitro and in-vivo inhibitory activity of biflorin in melanoma

Melanoma Research

Volumn 21, Issue 2, 2011, Pages 106-114

  Vasconcellos, Marne C ^a   Bezerra, Daniel P ^d   Fonseca, Aluísio M ^c   Araújo, Ana Jérsia ^b   Pessoa, Cláudia ^b   Lemos, Telma L G ^c   Costa Lotufo, Letícia V ^b   De Moraes, Manoel Odorico ^b   Montenegro, Raquel C ^e,f  

^a FEDERAL UNIVERSITY OF AMAZONAS   (Brazil)

^b Faculdade de Medicina   (Brazil)

^c FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^d FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

^e FEDERAL UNIVERSITY OF PARÁ   (Brazil)

^f Instituto de Ciencias Biologicas   (Brazil)

Author keywords

Apoptosis; biflorin; cytotoxic activity; melanoma

Indexed keywords

ANTINEOPLASTIC AGENT; BIFLORIN; DACARBAZINE; DOXORUBICIN; PLANT EXTRACT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CANCER SURVIVAL; CAPRARIA BIFLORA; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; DNA FRAGMENTATION; DNA SYNTHESIS INHIBITION; DRUG ACTIVITY; DRUG EFFICACY; FEMALE; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; MELANOMA; MELANOMA B16; MELANOMA CELL; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCROPHULARIACEAE; SURVIVAL RATE;

ANIMALS; APOPTOSIS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; NAPHTHOQUINONES; SKIN NEOPLASMS;

EID: 79952986831     PISSN: 09608931     EISSN: None     Source Type: Journal    
DOI: 10.1097/CMR.0b013e328343ecc4     Document Type: Article

References (33)

1. Molenkampa BG, Van Leeuwena PAM, Van den Eertweghb AJM, Sluijter BJ, Scheper RJ, Meijer S, et al. Immunomodulation of the melanoma sentinel lymph node: a novel adjuvant therapeutic option. Immunobiology 2006;211:651-661.
2. Gogas HJ, Kirkwood JM, Sondak VK. Chemotherapy for metastatic melanoma. Time for a change? Cancer 2007;109:445-464.
3. Francis SO, Mahlberg MJ, Johnson KR, Ming ME, Dellavalle RP. Melanoma chemoprevention. J Am Acad Dermatol 2006;55:849-861. (Pubitemid 44556826)
4. Cragg GM, Newman DJ. Plants as a source of anti-cancer agents. J Ethnopharmacology 2005;100:72-79. (Pubitemid 41073525)
5. Newman DJ, Cragg MG. Natural products as sources of new drugs over the last 25 years. J Nat Prod 2007;70:461-477. (Pubitemid 46595760)
6. Lima OG, D'Albuquerque IL, Magalhães Neto B, Albuquerque MM. Brief note on the antimicrobial activity of biflorin purified by partition Craig. Rev Inst Antibiot 1958;1:95-98.
7. Lima OG, D'Albuquerque IL, Navarro MCP. New method of extraction and purification of biflorin with Industrial Possibility. Rev Inst Antibiot Recife 1962;4:79-81.
8. Vasconcellos MC, Montenegro RC, Militão GCG, Fonseca AM, Pessoa ODL, Lemos TLG, et al. Bioactivity of biflorin, a typical o-naphthoquinone isolated from Capraria biflora L. Z Naturforsch 2005;60:394-398. (Pubitemid 40968471)
9. Vasconcellos MC, Bezerra DP, Fonseca AM, Pereira MRP, Lemos TLG, Pessoa ODL, et al. Antitumor activity of biflorin, an o-naphthoquinone isolated from Capraria biflora. Biol Pharm Bull 2007;30:1416-1421. (Pubitemid 47287554)
10. Falkson CI, Falkson G, Falkson HC. Improved results with the addition of recombinant interferon a-2b to dacarbazine in the treatment of patients with metastatic malignant melanoma. J Clin Ocol 1991;9:1403-1408.
11. Falkson CI, Ibrahim J, Kirkwood JM, Coates AS, Atkins MB, Blum RH. Phase III trial of dacarbazine versus dacarbazine with interferon alpha-2b versus dacarbazine with tamoxifen versus dacarbazine with interferon alpha-2b and tamoxifen in patients with metastatic malignant melanoma: an Eastern Cooperative Oncology Group study. J Clin Oncol 1998;16:1743-1751.
12. 13C spectra of biflorin and bis-biflorin from Capraria biflora. Magn Reson Chem 2003;41:1038-1040. (Pubitemid 37521760)
13. Mosmann T. Rapid colorimetric assay for cellular growth and survivor: application to proliferation and cytotoxicity assays. J Immunol Methods 1993;65:55-63.
14. Asche C. Antitumour quinones. Mini Rev Med Chem 2005;5:449-467. (Pubitemid 40601636)
15. Driscoll JS, Hazard GF, Wood HB, Goldin A. Structure-antitumor activity relationships among quinone derivatives. Cancer Chemother Rep 2 1974;4:1-362.
16. Arandjelovic SS, Bjelogrlic KS, Malesevic NN, Tesic LjZ, Radulovic SS. Antitumor activity of Ru (III) complexes carrying beta-diketonato ligands in vitro and in vivo. J BUON 2009;14:271-279.
17. Ortiz R, Prados J, Melguizo C, Rama AR, Segura A, Rodríguez- Serrano F, et al. The cytotoxic activity of the phage e protein suppress the growth of murine B16 melanomas in vitro and in vivo. J Mol Med 2009;87:899-911.
18. Zamai L, Canonico B, Luchetti F, Ferri P, Melloni E, Guidotti L et al. Supravital exposure to propidium iodide identifies apoptosis on adherent cells. Cytometry 2001;44:57-64. (Pubitemid 32434003)
19. Los M, Burek CJ, Stroh C, Benedyk K, Hug H, Mackiewicz A. Anticancer drugs of tomorrow: apoptotic pathways as target for drug design. Drug Discovery Today 2003;8:67-77. (Pubitemid 36139900)
20. Brady HJM. Apoptosis methods and protocols. New Jersey: Humana Press; 2004.
21. Hu W, Kavanagh JJ. Anticancer therapy targeting the apoptotic pathway. Lancet Oncol 2003;4:721-729. (Pubitemid 37527207)
22. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257.
23. Vermes I, Haanen C, Reutelingsperger C. Flow cytometry of apoptotic cell death. J Immunol Methods 2000;243:167-190.
24. Kroemer G, Zamzami N, Susin SA. Mitochondrial control of apoptosis. Immunol Today 1997;18:44-51. (Pubitemid 27072433)
25. Green DR, Reed JC. Mitochondria and apoptosis. Science 1998;281:1309-1312. (Pubitemid 28406816)
26. Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000;6:513-519. (Pubitemid 30305900)
27. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P. Features of apoptotic cells measured by flow cytometry. Cytometry 1992;13:795-808.
28. Nagata S. Breakdown of chromosomal DNA. Cornea 2002;21:S2-S6. (Pubitemid 34188769)
29. Nagata S. Apoptotic DNA fragmentation. Exp Cell Res 2000;256:12-18. (Pubitemid 30211161)
30. Krysko DV, Berghe TV, D'Herde K, Vandenabeele P. Apoptosis and necrosis: detection, discrimination and phagocytosis. Methods 2008;44:205-221. (Pubitemid 351296447)
31. Hogland HC. Hematological complications of cancer chemotherapy. Semi Oncol 1982;9:95-102.
32. Gupta M, Mazumder UK, Kumar RS, Kumar TS. Antitumor activity and antioxident role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice. Acta Pharmacol Sin 2004;25:1070-1076. (Pubitemid 39071116)
33. Eggermont AMM, Kirkwood JM. Re-evaluating the role of dacarbazine in metastatic melanoma: what have we learned in 30 years? Eur J Cancer 2004;40:1825-1836. (Pubitemid 39036756)