Direct gene transfer with IP-10 mutant ameliorates mouse CVB3-induced myocarditis by blunting Th1 immune responses

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Yue, Yan ^a   Gui, Jun ^b   Ai, Wenqing ^b   Xu, Wei ^b   Xiong, Sidong ^a,b  

^a SOOCHOW UNIVERSITY   (China)

^b FUDAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; CREATINE KINASE MB; GAMMA INTERFERON; GAMMA INTERFERON INDUCIBLE PROTEIN 10; IMMUNOMODULATING AGENT; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 13; INTERLEUKIN 4; METHIONINE; MUTANT GAMMA INTERFERON INDUCIBLE PROTEIN 10; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARBOXY TERMINAL SEQUENCE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHEMOTAXIS; CONTROLLED STUDY; COXSACKIE VIRUS B3; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DRUG EFFICACY; GENE TRANSFER; HEART WEIGHT; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOMODULATION; MALE; MOUSE; MUTANT; NONHUMAN; PROTEIN EXPRESSION; TH1 CELL; VIRAL CLEARANCE; VIRUS LOAD; VIRUS MYOCARDITIS; WEIGHT FLUCTUATION; ANIMAL; GENE THERAPY; GENETICS; IMMUNOLOGY; MYOCARDITIS;

COXSACKIEVIRUS; ENTEROVIRUS; MUS;

ANIMALS; CHEMOKINE CXCL10; GENE THERAPY; GENE TRANSFER TECHNIQUES; MICE; MYOCARDITIS; TH1 CELLS;

EID: 79952982782     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018186     Document Type: Article

References (40)

1. Calabrese F, Thiene G, (2003) Myocarditis and inflammatory cardiomyopathy: microbiological and molecular biological aspects. Cardiovasc Res 60: 11-25.
2. Maisch B, Ristic AD, Hufnagel G, Pankuweit S, (2002) Pathophysiology of viral myocarditis: the role of humoral immune response. Cardiovasc Pathol 11: 112-122.
3. Luo H, Wong J, Wong B, (2010) Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy. Cardiovasc Res 85: 347-356.
4. Jiang Z, Xu W, Li K, Yue Y, Xu L, et al. (2008) Remission of CVB3-induced viral myocarditis by in vivo Th2 polarization via hydrodynamics-based interleukin-4 gene transfer. J Gene Med 10: 918-929.
5. Huber SA, Feldman AM, Sartini D, (2006) Coxsackievirus B3 induces T regulatory cells, which inhibit cardiomyopathy in tumor necrosis factor-alpha transgenic mice. Circ Res 99: 1109-1116.
6. Seko Y, Takahashi N, Azuma M, Yagita H, Okumura K, et al. (1998) Effects of in vivo administration of anti-B7-1/B7-2 monoclonal antibodies on murine acute myocarditis caused by coxsackievirus B3. Circ Res 82: 613-618.
7. Pinkert S, Westermann D, Wang X, Klingel K, Dorner A, et al. (2009) Prevention of cardiac dysfunction in acute coxsackievirus B3 cardiomyopathy by inducible expression of a soluble coxsackievirus-adenovirus receptor. Circulation 120: 2358-2366.
8. Shen Y, Xu W, Chu YW, Wang Y, Liu QS, et al. (2004) Coxsackievirus group B type 3 infection upregulates expression of monocyte chemoattractant protein 1 in cardiac myocytes, which leads to enhanced migration of mononuclear cells in viral myocarditis. J Virol 78: 12548-12556.
9. Chen P, Chen R, Yang Y, Yu Y, Xie Y, et al. (2009) Coxsackievirus B3 infection promotes generation of myeloid dendritic cells from bone marrow and accumulation in the myocardium. Int Immunopharmacol 9: 1304-1312.
10. Filippatos G, Parissis JT, Adamopoulos S, Kardaras F, (2003) Chemokines in cardiovascular remodeling: clinical and therapeutic implications. Curr Mol Med 3: 139-147.
11. Frangogiannis NG, (2004) The role of the chemokines in myocardial ischemia and reperfusion. Curr Vasc Pharmacol 2: 163-174.
12. Bujak M, Dobaczewski M, Gonzalez-Quesada C, Xia Y, Leucker T, et al. (2009) Induction of the CXC chemokine interferon-gamma-inducible protein 10 regulates the reparative response following myocardial infarction. Circ Res 105: 973-983.
13. Weinzierl AO, Szalay G, Wolburg H, Sauter M, Rammensee HG, et al. (2008) Effective chemokine secretion by dendritic cells and expansion of cross-presenting CD4-/CD8+ dendritic cells define a protective phenotype in the mouse model of coxsackievirus myocarditis. J Virol 82: 8149-8160.
14. Shen Y, Xu W, Shao XA, Chen RZ, Yang YZ, et al. (2003) Infection of Coxsackievirus group B type 3 regulates the expression profile of chemokines in myocardial tissue/cells. Zhonghua Yi Xue Za Zhi 83: 981-985.
15. Zhang HM, Yuan J, Cheung P, Chau D, Wong BW, et al. (2005) Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression. Mol Cell Biol 25: 6247-6258.
16. Dufour JH, Dziejman M, Liu MT, Leung JH, Lane TE, et al. (2002) IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking. J Immunol 168: 3195-3204.
17. Vasquez RE, Soong L, (2006) CXCL10/gamma interferon-inducible protein 10-mediated protection against Leishmania amazonensis infection in mice. Infect Immun 74: 6769-6777.
18. Huber SA, Sartini D, Exley M, (2002) Vgamma4(+) T cells promote autoimmune CD8(+) cytolytic T-lymphocyte activation in coxsackievirus B3-induced myocarditis in mice: role for CD4(+) Th1 cells. J Virol 76: 10785-10790.
19. Hasegawa H, Inoue A, Kohno M, Muraoka M, Miyazaki T, et al. (2006) Antagonist of interferon-inducible protein 10/CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL/lpr mice. Arthritis Rheum 54: 1174-1183.
20. Tam PE, (2006) Coxsackievirus myocarditis: interplay between virus and host in the pathogenesis of heart disease. Viral Immunol 19: 133-146.
21. Shi Y, Chen C, Lisewski U, Wrackmeyer U, Radke M, et al. (2009) Cardiac deletion of the Coxsackievirus-adenovirus receptor abolishes Coxsackievirus B3 infection and prevents myocarditis in vivo. J Am Coll Cardiol 53: 1219-1226.
22. Maekawa Y, Ouzounian M, Opavsky MA, Liu PP, (2007) Connecting the missing link between dilated cardiomyopathy and viral myocarditis: virus, cytoskeleton, and innate immunity. Circulation 115: 5-8.
23. Maier R, Krebs P, Ludewig B, (2004) Immunopathological basis of virus-induced myocarditis. Clin Dev Immunol 11: 1-5.
24. Athanassopoulos P, Vaessen LM, Balk AH, Weimar W, Sharma HS, et al. (2006) Altered chemokine receptor profile on circulating leukocytes in human heart failure. Cell Biochem Biophys 44: 83-101.
25. Ikejima H, Imanishi T, Tsujioka H, Kashiwagi M, Kuroi A, et al. (2004) Upregulation of fractalkine and its receptor, CX3CR1, is associated with coronary plaque rupture in patients with unstable angina pectoris. Circ J 74: 337-345.
26. Rothenbacher D, Muller-Scholze S, Herder C, Koenig W, Kolb H, (2006) Differential expression of chemokines, risk of stable coronary heart disease, and correlation with established cardiovascular risk markers. Arterioscler Thromb Vasc Biol 26: 194-199.
27. Li K, Xu W, Guo Q, Jiang Z, Wang P, et al. (2009) Differential macrophage polarization in male and female BALB/c mice infected with coxsackievirus B3 defines susceptibility to viral myocarditis. Circ Res 105: 353-364.
28. Yuan J, Liu Z, Lim T, Zhang H, He J, et al. (2009) CXCL10 inhibits viral replication through recruitment of natural killer cells in coxsackievirus B3-induced myocarditis. Circ Res 104: 628-638.
29. Lodge PA, Herzum M, Olszewski J, Huber SA, (1987) Coxsackievirus B-3 myocarditis. Acute and chronic forms of the disease caused by different immunopathogenic mechanisms. Am J Pathol 128: 455-463.
30. Esfandiarei M, McManus BM, (2008) Molecular biology and pathogenesis of viral myocarditis. Annu Rev Pathol 3: 127-155.
31. Frisancho-Kiss S, Coronado MJ, Frisancho JA, Lau VM, Rose NR, et al. (2009) Gonadectomy of male BALB/c mice increases Tim-3(+) alternatively activated M2 macrophages, Tim-3(+) T cells, Th2 cells and Treg in the heart during acute coxsackievirus-induced myocarditis. Brain Behav Immun 23: 649-657.
32. Singh UP, Singh R, Singh S, Karls RK, Quinn FD, et al. (2008) CXCL10+ T cells and NK cells assist in the recruitment and activation of CXCR3+ and CXCL11+ leukocytes during Mycobacteria-enhanced colitis. BMC Immunol 9: 25.
33. Agostini C, Cassatella M, Zambello R, Trentin L, Gasperini S, et al. (1998) Involvement of the IP-10 chemokine in sarcoid granulomatous reactions. J Immunol 161: 6413-6420.
34. Dixon AE, Mandac JB, Madtes DK, Martin PJ, Clark JG, (2000) Chemokine expression in Th1 cell-induced lung injury: prominence of IFN-gamma-inducible chemokines. Am J Physiol Lung Cell Mol Physiol 279: L592-599.
35. Gupta G, Bhattacharjee S, Bhattacharyya S, Bhattacharya P, Adhikari A, et al. (2009) CXC chemokine-mediated protection against visceral leishmaniasis: involvement of the proinflammatory response. J Infect Dis 200: 1300-1310.
36. Cihakova D, Barin JG, Afanasyeva M, Kimura M, Fairweather D, et al. (2008) Interleukin-13 protects against experimental autoimmune myocarditis by regulating macrophage differentiation. Am J Pathol 172: 1195-1208.
37. Yang X, Chu Y, Wang Y, Zhang R, Xiong S, (2006) Targeted in vivo expression of IFN-gamma-inducible protein 10 induces specific antitumor activity. J Leukoc Biol 80: 1434-1444.
38. Wan T, Zhou X, Chen G, An H, Chen T, et al. (2004) Novel heat shock protein Hsp70L1 activates dendritic cells and acts as a Th1 polarizing adjuvant. Blood 103: 1747-1754.
39. Wang P, Yang X, Xu W, Li K, Chu Y, et al. (2010) Integrating individual functional moieties of CXCL10 and CXCL11 into a novel chimeric chemokine leads to synergistic antitumor effects: a strategy for chemokine-based multi-target-directed cancer therapy. Cancer Immunol Immunother 59: 1715-1726.
40. Grabie N, Delfs MW, Westrich JR, Love VA, Stavrakis G, et al. (2003) IL-12 is required for differentiation of pathogenic CD8+ T cell effectors that cause myocarditis. J Clin Invest 111: 671-680.