Studying Fungal Pathogenesis in Drosophila

Microbe

Volumn 5, Issue 7, 2010, Pages 291-296

  Kontoyiannis, Dimitrios P ^a   Lewis, Russell E ^b  

^a UNIVERSITY OF TEXAS   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79952982353     PISSN: 15587452     EISSN: 15587460     Source Type: Journal    
DOI: 10.1128/microbe.5.291.1     Document Type: Article

References (11)

1. Alarco, A. M., A. Marcil, J. Chen, B. Suter, D. Thomas, and M. Whiteway. 2004. Immune deficient Drosophila melanogaster:A model for the innate immune response to human fungal pathogens. J. Immunol. 172:5622-5628.
2. Ben-Ami, R., G. A. Lamaris, R. E. Lewis, and D. P. Kontoyiannis. 2009. Interstrain variability in the virulence of Aspergillus fumigatus and Aspergillus terreus in a Toll-deficient Drosophila fly model of invasive aspergillosis. Med. Mycol. 29:1-9.
3. Chamilos, G., R. E. Lewis, J. Hu, L. Xiao, T. Zal, M. Gilliet, G. Halder, and D. P. Kontoyiannis. 2008. Drosophila melanogaster as a model host to dissect the immunopathogenesis of zygomycosis. Proc. Natl. Acad. Sci. USA 105:9367-9372.
4. Chamilos, G., M. S. Lionakis, R. E. Lewis, and D. P. Kontoyiannis. 2007. Role of mini-host models in the study of medically important fungi. Lancet Infect. Dis. 7:42-55.
5. Chamilos, G., M. S. Lionakis, R. E. Lewis, J. L. Lopez-Ribot, S. P. Saville, N. D. Albert, G. Halder, and D. P. Kontoyiannis. 2006. Drosophila melanogaster as a facile model for large-scale studies of virulence mechanisms and antifungal drug efficacy in Candida species. J. Infect. Dis. 193:1014-1022.
6. Chamilos, G., C. J. Nobile, V. M. Bruno, R. E. Lewis, A. P. Mitchell, and D. P. Kontoyiannis. 2009. Candida albicans Cas5, a regulator of cell wall integrity, is required for virulence in murine and toll mutant fly models. J. Infect. Dis. 200:152-157.
7. Lamaris, G. A., R. Ben-Ami, R. E. Lewis, and D. P. Kontoyiannis. 2008. Does pre exposure of Aspergillus fumigatus to voriconazole or posaconazole in vitro affect its virulence and the in vivo activity of subsequent posaconazole or voriconazole, respectively? A study in a fly model of aspergillosis. J. Antimicrob. Chemother. 62:539-542.
8. Lamaris, G. A., G. Chamilos, R. E. Lewis, and D. P. Kontoyiannis. 2007. Virulence studies of Scedosporium and Fusarium species in Drosophila melanogaster. J. Infect. Dis. 196:1860-1864.
9. Lemaitre, B. 2004. The road to Toll. Nature Rev. Immunol. 4:521-527.
10. Lemaitre, B., E. Nicolas, L. Michaut, J. M. Reichhart, and J. A. Hoffmann. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983.
11. Lionakis, M. S., R. E. Lewis, G. S. May, N. P. Wiederhold, N. D. Albert, G. Halder, and D. P. Kontoyiannis. 2005. Toll-deficient Drosophila flies as a fast, high-throughput model for the study of antifungal drug efficacy against invasive aspergillosis and Aspergillus virulence. J. Infect. Dis. 191:1188-1195.