Evaluation of deuterium labeled and unlabeled bis-methyl glutathione combined with nanoliquid chromatography-mass spectrometry to screen and characterize reactive drug metabolites

Chemical Research in Toxicology

Volumn 24, Issue 3, 2011, Pages 412-417

  Defoy, Daniel ^a   Dansette, Patrick M ^b   Neugebauer, Witold ^a   Wagner, J Richard ^a   Klarskov, Klaus ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBAMAZEPINE; CARBOXYLIC ACID; DEUTERIUM; DRUG METABOLITE; GLUTATHIONE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CHEMICAL LABELING; CONTROLLED STUDY; DRUG SCREENING; DRUG TRANSFORMATION; ELECTROSPRAY MASS SPECTROMETRY; ESTERIFICATION; IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROSOME;

ACETAMINOPHEN; ANIMALS; CARBAMAZEPINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEUTERIUM; DEUTERIUM EXCHANGE MEASUREMENT; ESTERIFICATION; GLUTATHIONE; ISOTOPE LABELING; MALE; MICROSOMES; NADP; NANOTECHNOLOGY; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 79952971117     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx1003694     Document Type: Article

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