Pharmacokinetics of ropivacaine in patients with chronic renal failure

British Journal of Anaesthesia

Volumn 106, Issue 4, 2011, Pages 512-521

  Pere, P J ^a   Ekstrand, A ^a   Salonen, M ^a   Honkanen, E ^a   Sjovall J ^b   Henriksson, J ^b   Rosenberg, P H ^a,c  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b ASTRAZENECA R AND D   (Sweden)

^c UNIVERSITY OF HELSINKI   (Finland)

Author keywords

kidney, failure; local anaesthetics; pharmacology, pharmacokinetics; toxicity, local anaesthetics

Indexed keywords

CREATININE; DRUG METABOLITE; LOCAL ANESTHETIC AGENT; OROSOMUCOID; ROPIVACAINE;

ADULT; AREA UNDER THE CURVE; ARTICLE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; DRUG URINE LEVEL; FEMALE; HUMAN; KIDNEY CLEARANCE; LONG TERM CARE; MALE; MAXIMUM PLASMA CONCENTRATION; PLASMA CLEARANCE; PLASMA CONCENTRATION-TIME CURVE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; TIME TO MAXIMUM PLASMA CONCENTRATION; UREMIA; URINARY EXCRETION;

EID: 79952968957     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aer002     Document Type: Article

References (19)

1. Ekström G, Gunnarsson UB. Ropivacaine, a new amide-type local anesthetic agent, is metabolized by cytochromes P450 1A and 3A in human liver microsomes. Drug Metab Dispos 1996; 24: 955-61 (Pubitemid 26314546)
2. Halldin MM, Bredberg E, Angelin B, et al. Metabolism and excretion of ropivacaine in humans. Drug Metab Dispos 1996; 24: 962-8 (Pubitemid 26314547)
3. Jokinen MJ, Neuvonen PJ, Lindgren L, et al. Pharmacokinetics of ropivacaine in patients with chronic end-stage liver disease. Anesthesiology 2007; 106: 43-55 (Pubitemid 46035402)
4. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41
5. Slot C. Plasma creatinine determination. A new and specific Jaffe reaction method. Scand J Clin Lab Invest 1965; 17: 381-7
6. Engman M, Neidenström P, Norsten-Höög C, Wiklund S-J, Bondesson U, Arvidsson T. Determination of ropivacaine and [2H3]ropivacaine in biological samples by gas chromatography with nitrogen-phosphorus detection or mass spectrometry. J Chromatogr B Biomed Sci Appl 1998; 709: 57-67 (Pubitemid 28238418)
7. Abdel-Rehim M, Bielenstein M, Askemark Y. Determination of ropivacaine and its metabolites in patient urine: Advantage of liquid chromatography-tandem mass spectrometry over liquid chromatography-UV detection and liquid chromatography-mass spectrometry. Anal Chim Acta 2003; 492: 253-60 (Pubitemid 37101405)
8. Arvidsson T, Askemark Y, Halldin MM. Liquid chromatographic bioanalytical determination of ropivacaine, bupivacaine and major metabolites. Biomed Chromatogr 1999; 13: 286-92 (Pubitemid 29326758)
9. Arlander E, Ekström G, Alm C, et al. Metabolism of ropivacaine in humans is mediated by CYP1A2 and to a minor extent by CYP3A4: An interaction study with fluvoxamine and ketoconazole as in vivo inhibitors. Clin Pharmacol Ther 1998; 64: 484-91 (Pubitemid 28531592)
10. Emanuelsson B-M, Persson J, Sandin S, Alm C, Gustafsson LL. Intraindividual and interindividual variability in the disposition of the local anesthetic ropivacaine in healthy subjects. Ther Drug Monit 1997; 19: 126-31 (Pubitemid 28056021)
11. Draper NR, Smith H. Applied Regression Analysis, 3rd Edn. John Wiley & Sons, Inc.: New York, 1998; 89-93
12. Rowland M, Tozer TN. Clinical Pharmacokinetics, Concepts and Applications. Williams & Wilkins: Baltimore, 1995; 257, 367
13. Reynolds F. Metabolism and excretion of bupivacaine in man: A comparison with mepivacaine. Br J Anaesth 1971; 43: 33-7
14. Varhe A, Olkkola KT, Neuvonen PJ. Diltiazem enhances the effects of triazolam by inhibiting its metabolism. Clin Pharmacol Ther 1996; 59: 369-75 (Pubitemid 26151618)
15. Zhou SF, Xue CC, Yu XQ, Li C, Wang G. Clinically important drug interactions potentially involving mechanism-based inhibition of cytochrome P450 3A4 and the role of therapeutic drug monitoring. Ther Drug Monit 2007; 29: 687-710 (Pubitemid 350190847)
16. Grossman SH, Davis D, Kitchell BB, Shand DG, Routledge PA. Diazepam and lidocaine plasma protein binding in renal disease. Clin Pharmacol Ther 1982; 31: 350-7 (Pubitemid 12125456)
17. Rosenberg PH, Pere P, Hekali R, Tuominen M. Plasma concentration of bupivacaine and two of its metabolites during continuous interscalene brachial plexus block. Br J Anaesth 1991; 66: 25-30
18. Erichsen CJ, Sjövall J, Kehlet H, Hedlund C, Arvidsson T. Pharmacokinetics and analgesic effect of ropivacaine during continuous epidural infusion for postoperative pain relief. Anesthesiology 1996; 84: 834-42 (Pubitemid 26105246)
19. Burm AGL, Stienstra R, Brouwer RP, Emanuelsson B-M, van Kleef JW. Epidural infusion of ropivacaine for postoperative analgesia after major postoperative surgery. Anesthesiology 2000; 93: 395-403 (Pubitemid 30620312)