메뉴 건너뛰기




Volumn 1222, Issue 1, 2011, Pages 90-99

Innovation in coronary artery disease and heart failure: Clinical benefits of pure heart rate reduction with ivabradine

Author keywords

Angina; Coronary artery disease; Heart failure; Heart rate; Ivabradine

Indexed keywords

ALDOSTERONE ANTAGONIST; AMLODIPINE; ANTILIPEMIC AGENT; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARDIAC GLYCOSIDE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; IVABRADINE; PLACEBO;

EID: 79952848474     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.05960.x     Document Type: Article
Times cited : (20)

References (42)
  • 1
    • 34548032376 scopus 로고    scopus 로고
    • Resting heart rate in cardiovascular disease
    • Fox, K., J.S. Borer, A.J. Camm, et al 2007. Resting heart rate in cardiovascular disease. J. Am. Coll. Cardiol. 50: 823-830.
    • (2007) J. Am. Coll. Cardiol. , vol.50 , pp. 823-830
    • Fox, K.1    Borer, J.S.2    Camm, A.J.3
  • 2
    • 0027229629 scopus 로고
    • Subsets of ambulatory myocardial ischemia based on heart rate activity. Circadian distribution and response to anti-ischemic medication. The Angina and Silent Ischemia Study Group (ASIS)
    • Andrews, T.C., T. Fenton, N. Toyosaki, et al 1993. Subsets of ambulatory myocardial ischemia based on heart rate activity. Circadian distribution and response to anti-ischemic medication. The Angina and Silent Ischemia Study Group (ASIS). Circulation 88: 92-100.
    • (1993) Circulation , vol.88 , pp. 92-100
    • Andrews, T.C.1    Fenton, T.2    Toyosaki, N.3
  • 3
    • 0034847517 scopus 로고    scopus 로고
    • Changes in heart rate and heart rate variability before ambulatory ischemic events(1)
    • Kop, W.J., R.J. Verdino, J.S. Gottdiener, et al 2001. Changes in heart rate and heart rate variability before ambulatory ischemic events(1). J. Am. Coll. Cardiol. 38: 742-749.
    • (2001) J. Am. Coll. Cardiol. , vol.38 , pp. 742-749
    • Kop, W.J.1    Verdino, R.J.2    Gottdiener, J.S.3
  • 4
    • 18344367496 scopus 로고    scopus 로고
    • Heart-rate profile during exercise as a predictor of sudden death
    • Jouven, X., J.P. Empana, P.J. Schwartz, et al 2005. Heart-rate profile during exercise as a predictor of sudden death. N. Engl. J. Med. 352: 1951-1958.
    • (2005) N. Engl. J. Med. , vol.352 , pp. 1951-1958
    • Jouven, X.1    Empana, J.P.2    Schwartz, P.J.3
  • 5
    • 0030752019 scopus 로고    scopus 로고
    • The relationship between resting heart rate and all-cause, cardiovascular and cancer mortality
    • Mensink, G.B. & H. Hoffmeister 1997. The relationship between resting heart rate and all-cause, cardiovascular and cancer mortality. Eur. Heart. J. 18: 1404-1410.
    • (1997) Eur. Heart. J. , vol.18 , pp. 1404-1410
    • Mensink, G.B.1    Hoffmeister, H.2
  • 6
    • 0025308219 scopus 로고
    • Influence of heart rate on mortality after acute myocardial infarction
    • Hjalmarson, A., E.A. Gilpin, J. Kjekshus, et al 1990. Influence of heart rate on mortality after acute myocardial infarction. Am. J. Cardiol. 65: 547-553.
    • (1990) Am. J. Cardiol. , vol.65 , pp. 547-553
    • Hjalmarson, A.1    Gilpin, E.A.2    Kjekshus, J.3
  • 7
    • 44449129008 scopus 로고    scopus 로고
    • Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST)
    • Kolloch, R., U.F. Legler, A. Champion, et al 2008. Impact of resting heart rate on outcomes in hypertensive patients with coronary artery disease: findings from the INternational VErapamil-SR/trandolapril STudy (INVEST). Eur. Heart. J. 29: 1327-1334.
    • (2008) Eur. Heart. J. , vol.29 , pp. 1327-1334
    • Kolloch, R.1    Legler, U.F.2    Champion, A.3
  • 8
    • 50649089781 scopus 로고    scopus 로고
    • Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial
    • Fox, K., I. Ford, P.G. Steg, et al 2008. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet 372: 817-821.
    • (2008) Lancet , vol.372 , pp. 817-821
    • Fox, K.1    Ford, I.2    Steg, P.G.3
  • 9
    • 77956618692 scopus 로고    scopus 로고
    • Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomized placebo-controlled trial
    • Bohm, M., K. Swedberg, M. Komajda, et al 2010. Heart rate as a risk factor in chronic heart failure (SHIFT): the association between heart rate and outcomes in a randomized placebo-controlled trial. Lancet 376: 886-894.
    • (2010) Lancet , vol.376 , pp. 886-894
    • Bohm, M.1    Swedberg, K.2    Komajda, M.3
  • 10
    • 0035853053 scopus 로고    scopus 로고
    • Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial
    • Lechat, P., J.S. Hulot, S. Escolano, et al 2001. Heart rate and cardiac rhythm relationships with bisoprolol benefit in chronic heart failure in CIBIS II Trial. Circulation 103: 1428-1433.
    • (2001) Circulation , vol.103 , pp. 1428-1433
    • Lechat, P.1    Hulot, J.S.2    Escolano, S.3
  • 11
    • 37148999048 scopus 로고    scopus 로고
    • Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials
    • Cucherat, M. 2007. Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: a meta-regression of randomized clinical trials. Eur. Heart. J. 28: 3012-3019.
    • (2007) Eur. Heart. J. , vol.28 , pp. 3012-3019
    • Cucherat, M.1
  • 12
    • 40149089700 scopus 로고    scopus 로고
    • Analysis of randomized controlled trials on the effect of magnitude of heart rate reduction on clinical outcomes in patients with systolic chronic heart failure receiving beta-blockers
    • Flannery, G., R. Gehrig-Mills, B. Billah, et al 2008. Analysis of randomized controlled trials on the effect of magnitude of heart rate reduction on clinical outcomes in patients with systolic chronic heart failure receiving beta-blockers. Am. J. Cardiol. 101: 865-869.
    • (2008) Am. J. Cardiol. , vol.101 , pp. 865-869
    • Flannery, G.1    Gehrig-Mills, R.2    Billah, B.3
  • 13
    • 66649100010 scopus 로고    scopus 로고
    • Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure
    • McAlister, F.A., N. Wiebe, J.A. Ezekowitz, et al 2009. Meta-analysis: beta-blocker dose, heart rate reduction, and death in patients with heart failure. Ann. Intern. Med. 150: 784-794.
    • (2009) Ann. Intern. Med. , vol.150 , pp. 784-794
    • McAlister, F.A.1    Wiebe, N.2    Ezekowitz, J.A.3
  • 14
    • 78651329239 scopus 로고    scopus 로고
    • Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling
    • Ceconi, C., L. Comini, S. Suffredini, et al 2011. Heart rate reduction with ivabradine prevents the global phenotype of left ventricular remodeling. Am. J. Physiol. Heart. Circ. Physiol. 300: H366-H373.
    • (2011) Am. J. Physiol. Heart. Circ. Physiol. , vol.300
    • Ceconi, C.1    Comini, L.2    Suffredini, S.3
  • 15
    • 77956612624 scopus 로고    scopus 로고
    • Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled trial
    • Swedberg, K., M. Komajda, M. Bohm, et al 2010. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled trial. Lancet 376: 875-885.
    • (2010) Lancet , vol.376 , pp. 875-885
    • Swedberg, K.1    Komajda, M.2    Bohm, M.3
  • 16
    • 0018387132 scopus 로고
    • How does adrenaline accelerate the heart?
    • Brown, H.F., D. DiFrancesco & S.J. Noble 1979. How does adrenaline accelerate the heart? Nature 280: 235-236.
    • (1979) Nature , vol.280 , pp. 235-236
    • Brown, H.F.1    DiFrancesco, D.2    Noble, S.J.3
  • 17
    • 0027530224 scopus 로고
    • Pacemaker mechanisms in cardiac tissue
    • DiFrancesco, D. Pacemaker mechanisms in cardiac tissue. 1993. Annu. Rev. Physiol. 55: 455-472.
    • (1993) Annu. Rev. Physiol. , vol.55 , pp. 455-472
    • DiFrancesco, D.1
  • 18
    • 55249085851 scopus 로고    scopus 로고
    • Characterization of the heart rate-lowering action of ivabradine, a selective I(f) current inhibitor
    • Borer, J.S. & J.Y. Heuzey 2008. Characterization of the heart rate-lowering action of ivabradine, a selective I(f) current inhibitor. Am. J. Ther. 15: 461-473.
    • (2008) Am. J. Ther. , vol.15 , pp. 461-473
    • Borer, J.S.1    Heuzey, J.Y.2
  • 19
    • 0028358379 scopus 로고
    • Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49
    • Thollon, C., C. Cambarrat, J. Vian, et al 1994. Electrophysiological effects of S 16257, a novel sino-atrial node modulator, on rabbit and guinea-pig cardiac preparations: comparison with UL-FS 49. Br. J. Pharmacol. 112: 37-42.
    • (1994) Br. J. Pharmacol. , vol.112 , pp. 37-42
    • Thollon, C.1    Cambarrat, C.2    Vian, J.3
  • 20
    • 0029744373 scopus 로고    scopus 로고
    • Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells
    • Bois, P., J. Bescond, B. Renaudon & J. Lenfant 1996. Mode of action of bradycardic agent, S 16257, on ionic currents of rabbit sinoatrial node cells. Br. J. Pharmacol. 118: 1051-1057.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1051-1057
    • Bois, P.1    Bescond, J.2    Renaudon, B.3    Lenfant, J.4
  • 21
    • 0042357093 scopus 로고    scopus 로고
    • Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology
    • Camm, A.J. & C.P. Lau 2003. Electrophysiological effects of a single intravenous administration of ivabradine (S 16257) in adult patients with normal baseline electrophysiology. Drugs. R. D. 4: 83-89.
    • (2003) Drugs. R. D. , vol.4 , pp. 83-89
    • Camm, A.J.1    Lau, C.P.2
  • 22
    • 0029582832 scopus 로고
    • Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs
    • Simon, L., B. Ghaleh, L. Puybasset, et al 1995. Coronary and hemodynamic effects of S 16257, a new bradycardic agent, in resting and exercising conscious dogs. J. Pharmacol. Exp. Ther. 275: 659-666.
    • (1995) J. Pharmacol. Exp. Ther. , vol.275 , pp. 659-666
    • Simon, L.1    Ghaleh, B.2    Puybasset, L.3
  • 23
    • 0142169934 scopus 로고    scopus 로고
    • Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs
    • Vilaine, J.P., J.P. Bidouard, L. Lesage, et al 2003. Anti-ischemic effects of ivabradine, a selective heart rate-reducing agent, in exercise-induced myocardial ischemia in pigs. J. Cardiovasc. Pharmacol. 42: 688-696.
    • (2003) J. Cardiovasc. Pharmacol. , vol.42 , pp. 688-696
    • Vilaine, J.P.1    Bidouard, J.P.2    Lesage, L.3
  • 24
    • 0037305154 scopus 로고    scopus 로고
    • Contributions of heart rate and contractility to myocardial oxygen balance during exercise
    • Colin, P., B. Ghaleh, X. Monnet, et al 2003. Contributions of heart rate and contractility to myocardial oxygen balance during exercise. Am. J. Physiol. Heart. Circ. Physiol. 284: H676-H682.
    • (2003) Am. J. Physiol. Heart. Circ. Physiol. , vol.284
    • Colin, P.1    Ghaleh, B.2    Monnet, X.3
  • 25
    • 70449720719 scopus 로고    scopus 로고
    • Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart
    • Ceconi, C., A. Cargnoni, G. Francolini, et al 2009. Heart rate reduction with ivabradine improves energy metabolism and mechanical function of isolated ischaemic rabbit heart. Cardiovasc. Res. 84: 72-82.
    • (2009) Cardiovasc. Res. , vol.84 , pp. 72-82
    • Ceconi, C.1    Cargnoni, A.2    Francolini, G.3
  • 26
    • 52449095304 scopus 로고    scopus 로고
    • Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction
    • Heusch, G., A. Skyschally, P. Gres, et al 2008. Improvement of regional myocardial blood flow and function and reduction of infarct size with ivabradine: protection beyond heart rate reduction. Eur. Heart. J. 29: 2265-2275.
    • (2008) Eur. Heart. J. , vol.29 , pp. 2265-2275
    • Heusch, G.1    Skyschally, A.2    Gres, P.3
  • 27
    • 11144356194 scopus 로고    scopus 로고
    • Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure
    • Mulder, P., S. Barbier, A. Chagraoui, et al 2004. Long-term heart rate reduction induced by the selective I(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation 109: 1674-1679.
    • (2004) Circulation , vol.109 , pp. 1674-1679
    • Mulder, P.1    Barbier, S.2    Chagraoui, A.3
  • 28
    • 0037448788 scopus 로고    scopus 로고
    • Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial
    • Borer, J.S., K. Fox, P. Jaillon & G. Lerebours 2003. Antianginal and antiischemic effects of ivabradine, an I(f) inhibitor, in stable angina: a randomized, double-blind, multicentered, placebo-controlled trial. Circulation 107: 817-823.
    • (2003) Circulation , vol.107 , pp. 817-823
    • Borer, J.S.1    Fox, K.2    Jaillon, P.3    Lerebours, G.4
  • 29
    • 27944492366 scopus 로고    scopus 로고
    • Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina
    • Tardif, J.C., I. Ford, M. Tendera, et al 2005. Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur. Heart. J. 26: 2529-2536.
    • (2005) Eur. Heart. J. , vol.26 , pp. 2529-2536
    • Tardif, J.C.1    Ford, I.2    Tendera, M.3
  • 30
    • 0345866810 scopus 로고    scopus 로고
    • Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs
    • Colin, P., B. Ghaleh, X. Monnet, et al 2004. Effect of graded heart rate reduction with ivabradine on myocardial oxygen consumption and diastolic time in exercising dogs. J. Pharmacol. Exp. Ther. 308: 236-240.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 236-240
    • Colin, P.1    Ghaleh, B.2    Monnet, X.3
  • 31
    • 33947233212 scopus 로고    scopus 로고
    • Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial
    • Ruzyllo, W., M. Tendera, I. Ford & K.M. Fox 2007. Antianginal efficacy and safety of ivabradine compared with amlodipine in patients with stable effort angina pectoris: a 3-month randomised, double-blind, multicentre, noninferiority trial. Drugs 67: 393-405.
    • (2007) Drugs , vol.67 , pp. 393-405
    • Ruzyllo, W.1    Tendera, M.2    Ford, I.3    Fox, K.M.4
  • 32
    • 36249000685 scopus 로고    scopus 로고
    • Long-term safety and efficacy of ivabradine in patients with chronic stable angina
    • Lopez-Bescos, L., S. Filipova & R. Martos 2007. Long-term safety and efficacy of ivabradine in patients with chronic stable angina. Cardiology 108: 387-396.
    • (2007) Cardiology , vol.108 , pp. 387-396
    • Lopez-Bescos, L.1    Filipova, S.2    Martos, R.3
  • 33
    • 63349103473 scopus 로고    scopus 로고
    • Efficacy of the If current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4 month, randomized, placebo-controlled trial
    • Tardif, J.C., P. Ponikowski & T. Kahan 2009. Efficacy of the If current inhibitor ivabradine in patients with chronic stable angina receiving beta-blocker therapy: a 4 month, randomized, placebo-controlled trial. Eur. Heart. J. 30: 540-548.
    • (2009) Eur. Heart. J. , vol.30 , pp. 540-548
    • Tardif, J.C.1    Ponikowski, P.2    Kahan, T.3
  • 34
    • 79952832613 scopus 로고    scopus 로고
    • Summary of product characteristics. Procoralan European Medicines Agency. Available at: Accessed: 23-11-2010.
    • Summary of product characteristics. Procoralan European Medicines Agency. Available at: Accessed: 23-11-2010.
  • 35
    • 66049159033 scopus 로고    scopus 로고
    • Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris
    • Tendera, M., J. Borer & J. Tardif 2009. Efficacy of I(f) inhibition with ivabradine in different subpopulations with stable angina pectoris. Cardiology 114: 116-125.
    • (2009) Cardiology , vol.114 , pp. 116-125
    • Tendera, M.1    Borer, J.2    Tardif, J.3
  • 36
    • 50649109186 scopus 로고    scopus 로고
    • Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial
    • Fox, K., I. Ford, P.G. Steg, et al 2008. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet 372: 807-816.
    • (2008) Lancet , vol.372 , pp. 807-816
    • Fox, K.1    Ford, I.2    Steg, P.G.3
  • 37
    • 70349669250 scopus 로고    scopus 로고
    • Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial
    • Fox, K., I. Ford, P.G. Steg, et al 2009. Relationship between ivabradine treatment and cardiovascular outcomes in patients with stable coronary artery disease and left ventricular systolic dysfunction with limiting angina: a subgroup analysis of the randomized, controlled BEAUTIFUL trial. Eur. Heart. J. 30: 2337-2345.
    • (2009) Eur. Heart. J. , vol.30 , pp. 2337-2345
    • Fox, K.1    Ford, I.2    Steg, P.G.3
  • 38
    • 0035949564 scopus 로고    scopus 로고
    • Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption
    • Heidland, U.E. & B.E. Strauer 2001. Left ventricular muscle mass and elevated heart rate are associated with coronary plaque disruption. Circulation 104: 1477-1482.
    • (2001) Circulation , vol.104 , pp. 1477-1482
    • Heidland, U.E.1    Strauer, B.E.2
  • 39
    • 44949127974 scopus 로고    scopus 로고
    • Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice
    • Drouin, A., M.E. Gendron, E. Thorin, et al 2008. Chronic heart rate reduction by ivabradine prevents endothelial dysfunction in dyslipidaemic mice. Br. J. Pharmacol. 154: 749-757.
    • (2008) Br. J. Pharmacol. , vol.154 , pp. 749-757
    • Drouin, A.1    Gendron, M.E.2    Thorin, E.3
  • 40
    • 43249091146 scopus 로고    scopus 로고
    • Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice
    • Custodis, F., M. Baumhakel, N. Schlimmer, et al 2008. Heart rate reduction by ivabradine reduces oxidative stress, improves endothelial function, and prevents atherosclerosis in apolipoprotein E-deficient mice. Circulation 117: 2377-2387.
    • (2008) Circulation , vol.117 , pp. 2377-2387
    • Custodis, F.1    Baumhakel, M.2    Schlimmer, N.3
  • 41
    • 77955433087 scopus 로고    scopus 로고
    • Ivabradine: advantages throughout the cardiovascular continuum
    • Fox, K. 2010. Ivabradine: advantages throughout the cardiovascular continuum. Eur. Heart. J. Suppl. 12:C16-C20.
    • (2010) Eur. Heart. J. Suppl. , vol.12
    • Fox, K.1
  • 42
    • 53549085406 scopus 로고    scopus 로고
    • ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM)
    • Dickstein, K., A. Cohen-Solal, G. Filippatos, et al 2008. ESC guidelines for the diagnosis and treatment of acute and chronic heart failure 2008. The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2008 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association of the ESC (HFA) and endorsed by the European Society of Intensive Care Medicine (ESICM). Eur. J. Heart. Fail. 10: 933-989.
    • (2008) Eur. J. Heart. Fail. , vol.10 , pp. 933-989
    • Dickstein, K.1    Cohen-Solal, A.2    Filippatos, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.