A novel role of RASSF9 in maintaining epidermal homeostasis

PLoS ONE

Volumn 6, Issue 3, 2011, Pages

  Lee, Chiou Mei ^a,b   Yang, Polung ^b   Chen, Lih Chyang ^b   Chen, Chia Chun ^b   Wu, Shinn Chih ^c   Cheng, Hsiao Yun ^b   Chang, Yu Sun ^b  

^a CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^b CHANG GUNG UNIVERSITY   (Taiwan)

^c NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; LATENT MEMBRANE PROTEIN 1; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 9; UNCLASSIFIED DRUG; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; RASSF9 PROTEIN, HUMAN; VESICULAR TRANSPORT PROTEIN;

AGING; ALOPECIA; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL GROWTH; CELL PROLIFERATION; CHROMOSOME DELETION; CONTROLLED STUDY; EPIDERMIS; GENE EXPRESSION; GENE FUNCTION; GENE INSERTION; GENE MUTATION; GENE SILENCING; GROWTH INHIBITION; GROWTH RETARDATION; HOMEOSTASIS; HOMOZYGOSITY; IMMUNOFLUORESCENCE; IN SITU HYBRIDIZATION; KERATINOCYTE; LIFESPAN; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT; TRANSGENE; ANIMAL; GENE EXPRESSION PROFILING; GENETICS; HUMAN; PHYSIOLOGY; SOUTHERN BLOTTING; TRANSGENIC MOUSE; WESTERN BLOTTING;

ADENOVIRIDAE; HUMAN HERPESVIRUS 4; MUS;

ANIMALS; BLOTTING, SOUTHERN; BLOTTING, WESTERN; CYCLIN-DEPENDENT KINASE INHIBITOR P21; EPIDERMIS; GENE EXPRESSION PROFILING; HOMEOSTASIS; HUMANS; IN SITU HYBRIDIZATION; MICE; MICE, TRANSGENIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VESICULAR TRANSPORT PROTEINS;

EID: 79952844936     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0017867     Document Type: Article

References (48)

1. Sherwood V, Manbodh R, Sheppard C, Chalmers AD, (2008) RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Mol Biol Cell 19: 1772-1782.
2. Richter AM, Pfeifer GP, Dammann RH, (2009) The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta 1796: 114-128.
3. van der Weyden L, Adams DJ, (2007) The Ras-association domain family (RASSF) members and their role in human tumourigenesis. Biochim Biophys Acta 1776: 58-85.
4. Hesson LB, Dunwell TL, Cooper WN, Catchpoole D, Brini AT, et al. (2009) The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias. Mol Cancer 8: 42.
5. Sherwood V, Recino A, Jeffries A, Ward A, Chalmers AD, (2010) The N-terminal RASSF family: a new group of Ras-association-domain-containing proteins, with emerging links to cancer formation. Biochem J 425: 303-311.
6. Chen L, Johnson RC, Milgram SL, (1998) P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem 273: 33524-33532.
7. Rodriguez-Viciana P, Sabatier C, McCormick F, (2004) Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 24: 4943-4954.
8. Candi E, Schmidt R, Melino G, (2005) The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 6: 328-340.
9. Fuchs E, (1990) Epidermal differentiation. Curr Opin Cell Biol 2: 1028-1035.
10. Fitzsimons C, Engel N, Policastro L, Duran H, Molinari B, et al. (2002) Regulation of phospholipase C activation by the number of H(2) receptors during Ca(2+)-induced differentiation of mouse keratinocytes. Biochem Pharmacol 63: 1785-1796.
11. Millar SE, (2002) Molecular mechanisms regulating hair follicle development. J Invest Dermatol 118: 216-225.
12. Oro AE, Higgins K, (2003) Hair cycle regulation of Hedgehog signal reception. Dev Biol 255: 238-248.
13. Chen ML, Tsai CN, Liang CL, Shu CH, Huang CR, et al. (1992) Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein-Barr virus variant derived from the nasopharyngeal carcinoma in the Taiwanese population. Oncogene 7: 2131-2140.
14. Yeh TS, Li SN, Wu CJ, Liu ST, Meng CL, et al. (1997) Sequence variations between two Epstein-Barr virus LMP 1 variants have no effect on the activation of NF-kappaB activity. DNA Cell Biol 16: 1311-1319.
15. Ochman H, Gerber AS, Hartl DL, (1988) Genetic applications of an inverse polymerase chain reaction. Genetics 120: 621-623.
16. Takahashi K, Yan B, Yamanishi K, Imamura S, Coulombe PA, (1998) The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs. Genomics 53: 170-183.
17. Vasioukhin V, Bauer C, Degenstein L, Wise B, Fuchs E, (2001) Hyperproliferation and defects in epithelial polarity upon conditional ablation of alpha-catenin in skin. Cell 104: 605-617.
18. Benavides F, Starost MF, Flores M, Gimenez-Conti IB, Guenet JL, et al. (2002) Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation. Am J Pathol 161: 693-703.
19. Eckert RL, Crish JF, Robinson NA, (1997) The epidermal keratinocyte as a model for the study of gene regulation and cell differentiation. Physiol Rev 77: 397-424.
20. Missero C, Di Cunto F, Kiyokawa H, Koff A, Dotto GP, (1996) The absence of p21Cip1/WAF1 alters keratinocyte growth and differentiation and promotes ras-tumor progression. Genes Dev 10: 3065-3075.
21. Di Cunto F, Topley G, Calautti E, Hsiao J, Ong L, et al. (1998) Inhibitory function of p21Cip1/WAF1 in differentiation of primary mouse keratinocytes independent of cell cycle control. Science 280: 1069-1072.
22. Dirksen WP, Mohamed SA, Fisher SA, (2003) Splicing of a myosin phosphatase targeting subunit 1 alternative exon is regulated by intronic cis-elements and a novel bipartite exonic enhancer/silencer element. J Biol Chem 278: 9722-9732.
23. Rahkonen O, Su M, Hakovirta H, Koskivirta I, Hormuzdi S, et al. (2004) Mice With a Deletion in the First Intron of the Col1a1 Gene Develop Age-Dependent Aortic Dissection and Rupture. Circulation Research 94: 83.
24. Hovhannisyan RH, Carstens RP, (2005) A novel intronic cis element, ISE/ISS-3, regulates rat fibroblast growth factor receptor 2 splicing through activation of an upstream exon and repression of a downstream exon containing a noncanonical branch point sequence. Mol Cell Biol 25: 250-263.
25. Mercado PA, Ayala YM, Romano M, Buratti E, Baralle FE, (2005) Depletion of TDP 43 overrides the need for exonic and intronic splicing enhancers in the human apoA-II gene. Nucleic Acids Res 33: 6000-6010.
26. Wagner EJ, Baraniak AP, Sessions OM, Mauger D, Moskowitz E, et al. (2005) Characterization of the intronic splicing silencers flanking FGFR2 exon IIIb. J Biol Chem 280: 14017-14027.
27. Scamborova P, Wong A, Steitz JA, (2004) An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes. Mol Cell Biol 24: 1855-1869.
28. Chen J, Jackson PK, Kirschner MW, Dutta A, (1995) Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374: 386-388.
29. Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A, (1996) Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol 16: 4673-4682.
30. Karlsson T, Vahlquist A, Torma H, (2010) Keratinocyte differentiation induced by calcium, phorbol ester or interferon-gamma elicits distinct changes in the retinoid signalling pathways. J Dermatol Sci 57: 207-213.
31. Micallef L, Belaubre F, Pinon A, Jayat-Vignoles C, Delage C, et al. (2009) Effects of extracellular calcium on the growth-differentiation switch in immortalized keratinocyte HaCaT cells compared with normal human keratinocytes. Exp Dermatol 18: 143-151.
32. Fang NX, Gu W, Ding J, Saunders NA, Frazer IH, et al. (2007) Calcium enhances mouse keratinocyte differentiation in vitro to differentially regulate expression of papillomavirus authentic and codon modified L1 genes. Virology 365: 187-197.
33. Xie Z, Singleton PA, Bourguignon LY, Bikle DD, (2005) Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1. Mol Biol Cell 16: 3236-3246.
34. Missero C, Calautti E, Eckner R, Chin J, Tsai LH, et al. (1995) Involvement of the cell-cycle inhibitor Cip1/WAF1 and the E1A-associated p300 protein in terminal differentiation. Proc Natl Acad Sci U S A 92: 5451-5455.
35. Parker SB, Eichele G, Zhang P, Rawls A, Sands AT, et al. (1995) p53-independent expression of p21Cip1 in muscle and other terminally differentiating cells. Science 267: 1024-1027.
36. Todd C, Reynolds NJ, (1998) Up-regulation of p21WAF1 by phorbol ester and calcium in human keratinocytes through a protein kinase C-dependent pathway. Am J Pathol 153: 39-45.
37. Agell N, Bachs O, Rocamora N, Villalonga P, (2002) Modulation of the Ras/Raf/MEK/ERK pathway by Ca(2+), and calmodulin. Cell Signal 14: 649-654.
38. Bailleul B, Surani MA, White S, Barton SC, Brown K, et al. (1990) Skin hyperkeratosis and papilloma formation in transgenic mice expressing a ras oncogene from a suprabasal keratin promoter. Cell 62: 697-708.
39. Wang XJ, Greenhalgh DA, Roop DR, (2000) Transgenic coexpression of v-Ha-ras and transforming growth factor alpha increases epidermal hyperproliferation and tumorigenesis and predisposes to malignant conversion via endogenous c-Ha-ras activation. Mol Carcinog 27: 200-209.
40. Vaughan MB, Ramirez RD, Andrews CM, Wright WE, Shay JW, (2009) H-ras expression in immortalized keratinocytes produces an invasive epithelium in cultured skin equivalents. PLoS One 4: e7908.
41. Yuspa SH, Morgan DL, (1981) Mouse skin cells resistant to terminal differentiation associated with initiation of carcinogenesis. Nature 293: 72-74.
42. Lin AW, Lowe SW, (2001) Oncogenic ras activates the ARF-p53 pathway to suppress epithelial cell transformation. Proc Natl Acad Sci U S A 98: 5025-5030.
43. Tscharntke M, Pofahl R, Krieg T, Haase I, (2005) Ras-induced spreading and wound closure in human epidermal keratinocytes. FASEB J 19: 1836-1838.
44. Liu B, Zhu F, Xia X, Park E, Hu Y, (2009) A tale of terminal differentiation: IKKalpha, the master keratinocyte regulator. Cell Cycle 8: 527-531.
45. Schmidt M, Goebeler M, Posern G, Feller SM, Seitz CS, et al. (2000) Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. J Biol Chem 275: 41011-41017.
46. Chang MH, Ng CK, Lin YJ, Liang CL, Chung PJ, et al. (1997) Identification of a promoter for the latent membrane protein 1 gene of Epstein-Barr virus that is specifically activated in human epithelial cells. DNA Cell Biol 16: 829-837.
47. Tsai CL, Li HP, Lu YJ, Hsueh C, Liang Y, et al. (2006) Activation of DNA methyltransferase 1 by EBV LMP1 Involves c-Jun NH(2)-terminal kinase signaling. Cancer Res 66: 11668-11676.
48. Callard RE, Lau YL, Shields JG, Smith SH, Cairns J, et al. (1988) The marmoset B-lymphoblastoid cell line (B95-8) produces and responds to B-cell growth and differentiation factors: role of shed CD23 (sCD23). Immunology 65: 379-384.