Synthesis and psychotropic activity of some substituted aniline derivatives of 7-chloro-5-phenyl-1, 3-dihydro-1h, 3h-1, 4-benzodiazepine-2-one

International Journal of Pharmaceutical Sciences

Volumn 2, Issue 2 A, 2010, Pages 616-622

  Rashid, Mohd ^a   Ahmad, Bahar ^a   Mishra, Ravinesh ^a  

^a HAMDARD UNIVERSITY   (India)

Author keywords

1,4 benzodiazepine 2 one; Ethanol potentiation model; Neurotoxicity activity; Rotarod model

Indexed keywords

3 (2 CHLOROANILINEAMINE) 7 CHLORO 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE 5 PHENYL; 3 (2 METHYLANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 3 (3 CHLOROANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 3 (3 METHYLANILINEAMINE) 7 CHLORO 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE 5 PHENYL; 3 (4 BROMOANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 3 (4 CHLOROANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 3 (4 FLUOROANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 3 (4 N,N DIMETHYLANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 3 (4 NITROANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 3 (ANILINEAMINE) 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE; 7 CHLORO 5 PHENYL 1,3 DIHYDRO 1H,3H 1,4 BENZODIAZEPINE 2 ONE DERIVATIVE; ALCOHOL; ANILINE DERIVATIVE; BENZODIAZEPINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; MASS SPECTROMETRY; MOTOR COORDINATION; MOUSE; NEUROTOXICITY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; PSYCHOSIS; ROTAROD TEST; STRUCTURE ACTIVITY RELATION;

EID: 79952820555     PISSN: None     EISSN: 09754725     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Macdonald RL, Olsen RW. GABAa Receptor Channels, Annual Review of Neuroscience 1994; 17:569-602.
2. Villar HO, Davies MF, Loew GH, Maguire PA. Molecular models for recognition and activation at the benzodiazepine receptor: a review. Life Sci. 1991; 48:593-602.
3. Childress SJ, Gluckman MI. 1,4-Benzodiazepines. J. Pharm. Sci. 1964; 53:577-590.
4. Archer G A, Sternbach LH. Chemistry of benzodiazepines. Chem. Rev. 1968; 68:747-784.
5. Koechlin BA, Schwartz MA, Krol G, Oberhansli W. The metabolic fate of C-14-labeled chlordiazepoxide in man, in the dog, and in the rat. J Pharmacol Exp Ther. 1965; 148:399-411.
6. Ruehus HW, Lee JM, Album HE. Metabolism of diazepam in dogs: transformation to oxazepam, Arch. Biochem. Biophys. 1965 ; 111:376-380.
7. Randall LO, Gordon M. Psychopharmacological Agents. New York, Academic Press, ed 3, pp. 175-281-1974
8. Shader RI, Greenblatt DJ, Shader RI. Benzodiazepines in Clinical Practice, New York, Raven Press, pp. 183-196-1974
9. Norman GW, Perry R, James V, Charles C. Atropisomers of 1,4-benzodiazepines. Synthesis and resolution of a diazepam-related 1,4-benzodiazepine, J. Am. Chem. Soc. 1990; 112:3969-3978.
10. 1c, J. Org. Chem. 1962; 27:3788-3796.
11. Jackson B, Hester J, Allan DR, Kamdar BV. 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines which have central nervous system depressant activity. J. Med. Chem.1971;14:1078-1081.
12. Vijaya KR, Ashalatha BV, Narayana B. Synthesis of some new substituted triazolo [4,3-a][1,4] benzodiazepine derivatives as potent anticonvulsants. Eur. J. Med. Chem. 2006; 41:417-422.
13. Supuran CT, Popescu A, Ilisiu M, Costandache A, Banciu MD. Carbonic anhydrase inhibitors. Part 36. Inhibition of isozymes I and II with Schiff bases derived from chalkones and aromatic/heterocyclic sulphonamides. Eur. J. Med. Chem. 1996; 31:439-447.
14. Clerci F, Pocar D. Synthesis of 2-Amino-5-sulfanyl-1,3,4-thiadiazole derivatives and evaluation of their antidepressant and anxiolytic activity. J. Med. Chem. 2001; 44:931-936.
15. Kucukguzel I, Rollas S, Sanis G, Ozdemir O, Bayrak I, Altug T, Stables J. Synthesis of some 3-(Arylalkylthio)-4-alkyl/aryl-5-(4-aminophenyl)-4H-1,2,4-triazole derivatives and their anticonvulsant activity, Il farmaco. 2004;59:893-898.