Clinical importance of "low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H)" terminology for cervical smears: 5-Year analysis of the positive predictive value of LSIL-H compared with ASC-H, LSIL, and HSIL in the detection of high-grade cervical lesions with a review of the literature

Gynecologic Oncology

Volumn 121, Issue 1, 2011, Pages 152-156

  Ince, Umit ^a   Aydin, Ozlem ^b   Peker, Onder ^b  

^a ACIBADEM UNIVERSITY   (Turkey)

^b The Acibadem Healthcare Group   (Turkey)

Author keywords

Bethesda System; Cervical intraepithelial neoplasia (CIN); Cervical smear; Diagnostic category; Pap test; Squamous intraepithelial lesion (SIL)

Indexed keywords

CANCER RISK; CELL STRUCTURE; CONFERENCE PAPER; CONTROLLED STUDY; CYTOLOGY; DIAGNOSTIC VALUE; FEMALE; FOLLOW UP; HIGH GRADE UTERINE CERVIX SQUAMOUS INTRAEPITHELIAL LESION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LOW GRADE UTERINE CERVIX SQUAMOUS INTRAEPITHELIAL LESION; MAJOR CLINICAL STUDY; MEDICAL LITERATURE; PAPANICOLAOU TEST; PREDICTIVE VALUE; PRIORITY JOURNAL; UTERINE CERVIX BIOPSY; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX CYTOLOGY;

CERVICAL INTRAEPITHELIAL NEOPLASIA; FEMALE; HUMANS; TERMINOLOGY AS TOPIC; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS;

EID: 79952816370     PISSN: 00908258     EISSN: 10956859     Source Type: Journal    
DOI: 10.1016/j.ygyno.2010.12.004     Document Type: Conference Paper

References (37)

1. Solomon D, Davey D, Kurman R, Moriarty A, O'Connor D, Prey M, Raab S, Sherman M, Wilbur D, Wright Jr T, Young N. The 2001 Bethesda System terminology for reporting results of cervical cytology. JAMA 2002 Apr 24;287(16):2114-9.
2. Wright TC, Gatscha RM, Luff RD, Prey MU. Epithelial cell abnormalities: squamous. In: Solomon D, Nayar R, editors. The Bethesda System for reporting cervical cytology. Definitions, criteria and explanatory notes. 2nd ed. New York: Springer; 2004. p. 89-123. Chapter 5.
3. Herbert A, Gray W, Cross P. Terminology of the BSCC, European Community and the Bethesda System: the boundary between low-grade and high-grade cytology. [Editorial]. Cytopathology 2009 Feb;20(1):3-4.
4. McGrath CM, Kurtis JD, Yu GH. Evaluation of mild-to-moderate dysplasia on cervical-endocervical (Pap) smear: a subgroup of patients who bridge LSIL and HSIL. Diagn Cytopathol 2000 Oct;23(4):245-8.
5. Kir G, Cetiner H, Gurbuz A, Karateke A. Reporting of "LSIL with ASC-H" on cervicovaginal smears: is it a valid category to predict cases with HSIL follow-up? Eur J Gynaecol Oncol 2004;25(4):462-4.
6. Shidham VB, Kumar N, Narayan R, Brotzman GL. Should LSIL with ASC-H (LSIL-H) in cervical smears be an independent category? A study on SurePathTM specimens with review of literature [serial online]. Cyto J 2007 Mar 20;4:7.
7. Elsheikh TM, Kirkpatrick JL, Wu HH. The significance of "low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion" as a distinct squamous abnormality category in Papanicolaou tests. Cancer 2006 Oct 25;108(5):277-81.
8. Nasser SM, Cibas ES, Crum CP, Faguin WC. The significance of the Papanicolaou smear diagnosis of low-grade squamous intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesion. Cancer 2003 Oct 25;99(5):272-6. (Pubitemid 37248374)
9. Booth C, Massarani-Wafai R, Salhadar A, Weirick J, Wojcik EM. Is LSIL cannot exclude HSIL (LGHSIL) a valid Pap test interpretation [Abstract]. Mod Pathol 2005;18:61A.
10. Walsh BG, Michaels S, Steele C, Khurana KK. Clinical significance of the Pap smear diagnosis of LSIL cannot exclude HSIL: comparison with a patient population with pap smear findings of LSIL [Abstract]. Acta Cytol 2000;44:857.
11. Power P, Gregoire J, Duggan MA, Nation J. Low-grade Pap smears containing occasional high-grade cells as a predictor of high-grade dysplasia. J Obstet Gynaecol Can 2006 Oct;28(10):884-7.
12. Jain R, Pedigo MA, Powers CN, Frable WJ. Significance of reporting "LSIL-H" on cervical specimens [Abstract 55]. Cancer Cytopathol 2005 S5 Oct;105:355.
13. DiFurio M, Mailhoit T, Sundborg MJ, Naucheutz K. Comparison of the clinical significance of the Papanicolaou test interpretations LSIL cannot rule out HSIL and ASC-H. Diagn Cytopathol 2010 May;38(5):313-7.
14. Baker JJ, Fontana JL. "LSIL-H" cervicovaginal cytology specimens: biopsy follow-up and clinical significance [Abstract]. Acta Cytol 2004;48:668.
15. Saad RS, Mahdavy M, Takei H, Ruiz B. Clinical significance of cytologic diagnosis of low-grade squamous intraepithelial lesion with few cells suggestive of high grade: a cytohistologic correlation study [Abstract]. Acta Cytol 2004;48:659.
16. Underwood D, Prok A, Booth C, Brainard J, Chen L. Clinical outcomes of patients with a cytologic interpretation of "LSIL cannot exclude HSIL (LSIL-H)" in Pap test: a retrospective follow-up study [Abstract 61]. Cancer Cytopathol 2006 S5 Oct;108:378.
17. Howard MT, Cohen DW, Underwood DL, Deeds DA, Booth CN. Utilization of ASC-H, LSIL, cannot exclude HSIL (LSIL-H) and HSIL terminology following implementation of the ThinPrep imaging system [Abstract]. Mod Pathol 2007;20:71A.
18. Owens CL, Moats DR, Burroughs FH, Gustafson KS. "Low-grade Squamous Intraepithelial Lesion, Cannot Exclude High-grade Squamous Intraepithelial Lesion" is a distinct cytologic category: histologic outcomes and HPV prevalence. Am J Clin Pathol 2007 Sep;128(3):398-403. (Pubitemid 47479972)
19. Hong SR, Kim BM, Park JS, Choi KJ, Kim HS. Evaluation of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion on cervical smear [Abstract]. Cancer Cytopathol 2007 Oct S5;111:387.
20. Al-Nourhji O, Beckmann MJ, Markwell SJ, Massad LS. Pathology correlates of a Papanicolaou diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion. Cancer 2008 Dec 25;114(6):469-73.
21. Hunter C, Duggan MA, Duan Q, Power P, Gregoire J, Nation J. Cytology and outcome of LSIL: cannot exclude HSIL compared to ASC-H. Cytopathology 2009 Feb;20(1):17-26.
22. Alsharif M, Kjeldahl K, Curran C, Miller S, Gulbahce HE, Pambuccian SE. Clinical significance of the diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion. Cancer Cytopathol 2009 Apr 25;117(2):92-100.
23. Kumar N, Parameswaran L, Cafaro A, Basir Z, Behmaram B, Chavan AR, Shidham VB. LSIL with ASC-H in cervical smears-should it be an independent category for proper management and QA statistics? [Abstract]. Cancer Cytopathol 2005 S5 Oct;105:381.
24. O'Brien D, Brainard J, Chen L, Prok A, Booth C. Impact of the ThinPrep imaging system on the frequency of LSIL, cannot exclude HSIL: correlation on HPV and follow-up [Abstract 71]. Cancer Cytopathol 2006 S5 Oct;108:383.
25. Sherman ME, Abdul-Karim FW, Berec JS, Powers CN, Sidawy MK, Tabbara SO. Atypical squamous cells. In: Solomon D, Nayar R, editors. The Bethesda System for reporting cervical cytology. Definitions, criteria and explanatory notes. 2nd ed. New York: Springer; 2004. p. 67-89. Chapter 4.
26. Chivukula M, Shidham VB. ASC-H in Pap test-definitive categorization of cytomorphological spectrum. Cyto J 10 May 2006;3:14.
27. Nayar R, Wilbur DC, Solomon R. The Bethesda System for reporting cervical cytology. In: Bibbo M, Wilbur DC, editors. Comprehensive cytopathology. Third ed. Saunders Elsevier; 2008. p. 77-91. Chapter 7.
28. Simsir A, Ioffe O, Sun P, Elgert P, Cangiarella J, Levine PH. Effect of Bethesda 2001 on reporting of atypical squamous cells (ASC) with special emphasis on atypical squamous cells-cannot rule out high grade (ASC-H). Diagn Cytopathol 2006 Jan;34 (1):62-6.
29. Gage JC, Hanson VW, Abbey K, Dippery S, Gardner S, Kubota J, Schiffman M, Solomon D, Jeronimo J. Number of cervical biopsies and sensitivity of colposcopy. Obstet Gynecol 2006 Aug;108(2):264-72. (Pubitemid 44305665)
30. Sherman ME, Wang SS, Tarone R, Rich L, Schiffman M. Histopathologic extent of cervical intraepithelial neoplasia 3 lesions in the atypical squamous cells of undetermined significance low-grade squamous intraepithelial lesion triage study: implications for subject safety and lead-time bias. Cancer Epidemiol Biomark Prev 2003 Apr;12(4):372-9. (Pubitemid 36427999)
31. Jeronimo J, Schiffman M. Colposcopy at a crossroads. Am J Obstet Gynecol 2006 Aug;195(2):349-53. (Pubitemid 44160679)
32. Saab BA, Austin RM. Management of squamous intraepithelial lesions of indeterminate grade [Comment]. Am J Obstet Gynecol 2008 199:e13-e14; author reply e14.
33. Wright TCJ, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D. 2006 Consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol 2007 Oct;197(4):346-55.
34. Apgar BS, Kittendorf AL, Bettcher CM, Wong J, Kaufman AJ. Update on ASCCP consensus guidelines for abnormal cervical screening tests and cervical histology. Am Fam Physician 2009 Jul 15;80(2):147-55.
35. Nayar R, Solomon D. Support from authors of the Bethesda System. Cytopathology 2008 Dec;19(6):399-400.
36. Wright Jr TC, Cox JT, Massad LS, Twiggs LB, Wilkinson EJ. 2001 Consensus guidelines for the management of women with cervical cytological abnormalities. JAMA 2002 Apr 24;287(16):2120-9.
37. Prendiville W. The colposcopist's view. Cytopathology 2008 Jun 19(3):60-159.