Clinical significance of the diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion

Cancer Cytopathology

Volumn 117, Issue 2, 2009, Pages 92-100

  Alsharif, Mariam ^a   Kjeldahl, Klint ^b   Curran, Colleen ^b   Miller, Shelby ^b   Gulbahce, H Evin ^c   Pambuccian, Stefan E ^c  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL CENTER   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Atypical squamous cells; Cannot exclude high grade squamous intraepithelial lesion; Cannot exclude highgrade squamous intraepithelial lesion; Cervical cytology; Cervical dysplasia; High grade intraepithelial lesion; Indeterminate cytology; Low grade squamous intraepithelial lesion; Papanicolaou test; Squamous intraepithelial lesion

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; DIFFERENTIAL DIAGNOSIS; FEMALE; HOSPITALIZATION; HUMAN; METHODOLOGY; MIDDLE AGED; PATHOLOGY; PROGNOSIS; SQUAMOUS CELL CARCINOMA; STANDARD; UTERINE CERVIX CARCINOMA IN SITU; UTERINE CERVIX TUMOR; VAGINA SMEAR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CERVICAL INTRAEPITHELIAL NEOPLASIA; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; MIDDLE AGED; NEOPLASMS, SQUAMOUS CELL; PATHOLOGY, CLINICAL; PROGNOSIS; SEVERITY OF ILLNESS INDEX; UTERINE CERVICAL NEOPLASMS; VAGINAL SMEARS; YOUNG ADULT;

EID: 85047686955     PISSN: None     EISSN: 19346638     Source Type: Journal    
DOI: 10.1002/cncy.20004     Document Type: Article

References (42)

1. Solomon D, Davey D, Kurman R, et al. The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA. 2002;287:2114-2119.
2. Elsheikh TM, Kirkpatrick JL, Wu HH. The significance of "low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion" as a distinct squamous abnormality category in Papanicolaou tests. Cancer (Cancer Cytopathol). 2006;108:277-281.
3. Power P, Gregoire J, Duggan M, Nation J. Low-grade Pap smears containing occasional high-grade cells as a predictor of high-grade dysplasia. J Obstet Gynaecol Can. 2006;28: 884-887.
4. Owens CL, Moats DR, Burroughs FH, Gustafson KS. "Low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion" is a distinct cytologic category: histologic outcomes and HPV prevalence. Am J Clin Pathol. 2007;128:398-403.
5. Shidham VB, Kumar N, Narayan R, Brotzman GL. Should LSIL with ASC-H (LSIL-H) in cervical smears be an independent category? A study on SurePath specimens with review of literature [serial online]. Cytojournal. 2007;4:7.
6. Solomon D, Nayar R. The Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes. 2nd ed. New York, NY: Springer; 2004.
7. Nasser SM, Cibas ES, Crum CP, Faquin WC. The significance of the Papanicolaou smear diagnosis of low-grade squamous intraepithelial lesion cannot exclude high-grade squamous intraepithelial lesion. Cancer (Cancer Cytopathol). 2003;99:272-276.
8. Baker JJ, Fontana JL. "LSIL-H" cervicovaginal cytology specimens: biopsy follow-up and clinical significance [abstract]. Acta Cytol. 2004;48:668.
9. Kir G, Cetiner H, Gurbuz A, Karateke A. Reporting of "LSIL with ASC-H" on cervicovaginal smears: is it a valid category to predict cases with HSIL follow-up? Eur J Gynaecol Oncol. 2004;25:462-464.
10. Walsh BG, Michaels S, Steele C, Khurana KK. Clinical significance of the Pap smear diagnosis of LSIL cannot exclude HSIL: comparison with a patient population with Pap smear findings of LSIL [abstract]. Acta Cytol. 2000;44:857.
11. DiFurio M, Mailhoit T, Nauscheutz K. Comparison of the clinical significance of the Papanicolaou test interpretations LSIL cannot rule out HSIL and ASC-H. [abstract]. Cancer (Cancer Cytopathol). 2005;105:351.
12. Booth C, Massarani-Wafai R, Salhadar A, Weirick J, Wojcik EM. Is LSIL, cannot exclude HSIL (LGHSIL) a valid Pap test interpretation [abstract]? Mod Pathol. 2005;18:61A.
13. McGrath CM, Kurtis JD, Yu GH. Evaluation of mild-to-moderate dysplasia on cervical-endocervical (Pap) smear: a subgroup of patients who bridge LSIL and HSIL. Diagn Cytopathol. 2000;23:245-248.
14. Hunter C, Duggan MA, Duan Q, Power P, Gregoire J, Nation J. Cytology and outcome of LSIL: cannot exclude HSIL compared to ASC-H. Cytopathology. 2008;20:17-26.
15. Saad RS, Mahdavy M, Takei H, Ruiz B. Clinical significance of cytologic diagnosis of low-grade squamous intrae-pithelial lesion with few cells suggestive of high grade: a cytohistologic correlation study [abstract]. Acta Cytol. 2004;48:659.
16. Jain R, Pedigo MA, Powers CN, Frable WJ. Significance of reporting "LSIL-H" on cervical cytologic specimens [abstract]. Cancer (Cancer Cytopathol). 2005;105(5 suppl):355-356.
17. Hong SR, Kim BM, Park JS, Choi KJ, Kim HS, Kim HS. Evaluation of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion on cervical smear [abstract]. Cancer (Cancer Cytopathol). 2007;111(5 suppl):387.
18. O'Brien D, Brainard J, Chen L, Prok A, Booth C. Impact of the Thin Prep imaging system on the frequency of LSIL, cannot exclude HSIL: correlation of HPV and follow-up data [abstract]. Cancer (Cancer Cytopathol). 2006;108(5 suppl):383-384.
19. Underwood D, Prok A, Booth C, Brainard J, Chen L. Clinical outcomes of patients with a cytologic interpretation of "LSIL, cannot exclude HSIL (LSIL-H)" in Pap tests: a retrospective follow-up study [abstract]. Cancer (Cancer Cytopathol). 2006;108(5 suppl):378.
20. Howard MT, Cohen DW, Underwood DL, Deeds DA, Booth CN. Utilization of ASC-H, LSIL, cannot exclude HSIL (LSIL-H) and HSIL terminology following implementation of the Thin Prep imaging system [abstract]. Mod Pathol. 2007;20:71A.
21. Deeds D, Underwood DL, Booth CN. Comparison of Pap test five-year retrospective reviews for high grade squamous intraepithelial lesion (HSIL) and low grade squamous intraepithelial lesion, cannot exclude HSIL (LSIL-H) [abstract]. Cancer (Cancer Cytopathol). 2007;111(5 suppl): 447-448.
22. Howell LP, Zhou H, Wu W, Davis R. Significance of subclassifying high-grade squamous intraepithelial lesions into moderate dysplasia/CIN II versus severe dysplasia/CIN III/ CIS in the Bethesda System terminology. Diagn Cytopathol. 2004;30:362-366.
23. Saab BA, Austin RM. Management of squamous intraepi-thelial lesions of indeterminate grade [comment]. Am J Obstet Gynecol. 2008;199:e13-e14; author reply e14.
24. Duncan L, Jacob S, Hubbard E. Evaluation of p16INK4a as a diagnostic tool in the triage of Pap smears demonstrating atypical squamous cells of undetermined significance. Cancer (Cancer Cytopathol). 2008;114:34-48.
25. Monsonego J, Pollini G, Evrard MJ, et al. P16(INK4a) immunocytochemistry in liquid-based cytology samples in equivocal Pap smears: added value in management of women with equivocal Pap smear. Acta Cytol. 2007;51:755-766.
26. Wensveen CW, Kagie MJ, Veldhuizen RW, Trimbos JB, Boon ME. Combining HPV and MIB-1 tests reduces the number of colposcopies in women with equivocal cytology. Acta Obstet Gynecol Scand. 2006;85:1491-1495.
27. Tambouret RH, Misdraji J, Wilbur DC. Longitudinal clinical evaluation of a novel antibody cocktail for detection of high-grade squamous intraepithelial lesions on cervical cytology specimens. Arch Pathol Lab Med. 2008;132:918-925.
28. Herbert A, Bergeron C, Wiener H, et al. European guidelines for quality assurance in cervical cancer screening: recommendations for cervical cytology terminology. Cytopathology. 2007;18:213-219.
29. Denton KJ, Herbert A, Turnbull LS, et al. The revised BSCC terminology for abnormal cervical cytology. Cytopathology. 2008;19:137-157.
30. Jones BA, Novis DA. Cervical biopsy-cytology correlation. A College of American Pathologists Q-Probes study of 22,439 correlations in 348 laboratories. Arch Pathol Lab Med. 1996;120:523-531.
31. Molloy C, Dunton C, Edmonds P, Cunnane MF, Jenkins T. Evaluation of colposcopically directed cervical biopsies yielding a histologic diagnosis of CIN 1,2. J Low Genit Tract Dis. 2002;6:80-83.
32. Wright TCJ, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D. 2006 Consensus guidelines for the management of women with abnormal cervical cancer screening tests. Am J Obstet Gynecol. 2007;197:346-355.
33. Wright TC Jr, Cox JT, Massad LS, Twiggs LB, Wilkinson EJ. 2001 Consensus guidelines for the management of women with cervical cytological abnormalities. JAMA. 2002;287:2120-2129.
34. Genest DR, Dean B, Lee KR, Sheets E, Crum CP, Cibas ES. Qualifying the cytologic diagnosis of "atypical squamous cells of undetermined significance" affects the predictive value of a squamous intraepithelial lesion on subsequent biopsy. Arch Pathol Lab Med. 1998;122:338-341.
35. Sherman ME, Solomon D, Schiffman M. Qualification of ASCUS. A comparison of equivocal LSIL and equivocal HSIL cervical cytology in the ASCUS LSIL Triage Study. Am J Clin Pathol. 2001;116:386-394.
36. Reid-Nicholson M, Gatscha RM, Riedel ER, Lin O. Atypical squamous cells, cannot exclude high grade intraepithelial lesion (ASC-H): does HPV matter? Diagn Cytopathol. 2007;35:1-5.
37. Sherman ME, Castle PE, Solomon D. Cervical cytology of atypical squamous cells-cannot exclude high-grade squamous intraepithelial lesion (ASC-H): characteristics and histologic outcomes. Cancer (Cancer Cytopathol). 2006;108: 298-305.
38. McHale MT, Souther J, Elkas JC, Monk BJ, Harrison TA. Is atypical squamous cells that cannot exclude high-grade squamous intraepithelial lesion clinically significant? J Low Genit Tract Dis. 2007;11:86-89.
39. Bonvicino A, Huitron S, Fadare O. Papanicolaou test interpretations of "atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion": an investigation of requisite duration and number of colposcopic procedures to a definitive diagnosis of high-grade dysplasia in routine practice. Cancer (Cancer Cytopathol). 2007;111: 477-481.
40. Papanicolaou Society of Cytopathology Practice Guidelines Task Force. Papanicolaou Society of Cytopathology guidelines for educational notes, disclaimers, and similar comments on reports of cervical cytology specimens. Diagn Cytopathol. 2003;28:282-285.
41. Renshaw AA, Mody DR, Styer P, Schwartz M, Ducatman B, Colgan TJ. Papanicolaou tests with mixed high-grade and low-grade squamous intraepithelial lesion features: distinct performance in the College of American Pathologists Interlaboratory Comparison Program in Cervicovaginal Cytopathology. Arch Pathol Lab Med. 2006;130:456-459.
42. Wright TC Jr, Massad LS, Dunton CJ, Spitzer M, Wilkinson EJ, Solomon D. 2006 Consensus guidelines for the management of women with cervical intraepithelial neoplasia or adenocarcinoma in situ. J Low Genit Tract Dis. 2007;11:223-239.