Contribution of nitric oxide to the blood pressure and arterial responses to exercise in humans

Journal of Human Hypertension

Volumn 25, Issue 4, 2011, Pages 262-270

  Campbell, R ^a   Fisher, J P ^a   Sharman, J E ^b   McDonnell, B J ^c   Frenneaux, M P ^d  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY OF TASMANIA   (Australia)

^c CARDIFF METROPOLITAN UNIVERSITY   (United Kingdom)

^d UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

arteries; blood pressure; exercise; nitric oxide; vasculature

Indexed keywords

N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGEN; SODIUM CHLORIDE;

ADULT; ARTERIAL STIFFNESS; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; EXERCISE TEST; FEMALE; FEMORAL ARTERY; HEART OUTPUT; HEART RATE; HEART STROKE VOLUME; HUMAN; MALE; MEAN ARTERIAL PRESSURE; NORMAL HUMAN; OXYGEN CONSUMPTION; PULSE WAVE; RANDOMIZED CONTROLLED TRIAL; SYSTOLIC BLOOD PRESSURE;

ADULT; AORTA; BLOOD PRESSURE; COMPLIANCE; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; EXERCISE; EXERCISE TEST; FEMORAL ARTERY; HUMANS; INFUSIONS, INTRAVENOUS; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OMEGA-N-METHYLARGININE; OXYGEN CONSUMPTION; PULSATILE FLOW; TIME FACTORS;

EID: 79952816240     PISSN: 09509240     EISSN: 14765527     Source Type: Journal    
DOI: 10.1038/jhh.2010.53     Document Type: Article

References (55)

1. Le VV, Mitiku T, Sungar G, Myers J, Froelicher V. The blood pressure response to dynamic exercise testing: a systematic review. Prog Cardiovasc Dis 2008; 51(2): 135-160.
2. Miyai N, Arita M, Morioka I, Miyashita K, Nishio I, Takeda S. Exercise BP response in subjects with high-normal BP: exaggerated blood pressure response to exercise and risk of future hypertension in subjects with high-normal blood pressure. J Am Coll Cardiol 2000; 36(5): 1626-1631.
3. Singh JP, Larson MG, Manolio TA, O'Donnell CJ, Lauer M, Evans JC et al. Blood pressure response during treadmill testing as a risk factor for new-onset hypertension. The Framingham heart study. Circulation 1999; 99(14): 1831-1836. (Pubitemid 29181411)
4. Kurl S, Laukkanen JA, Rauramaa R, Lakka TA, Sivenius J, Salonen JT. Systolic blood pressure response to exercise stress test and risk of stroke. Stroke 2001; 32(9): 2036-2041. (Pubitemid 32868094)
5. Filipovsky J, Ducimetiere P, Safar ME. Prognostic significance of exercise blood pressure and heart rate in middle-aged men. Hypertension 1992; 20(3): 333-339.
6. Mundal R, Kjeldsen SE, Sandvik L, Erikssen G, Thaulow E, Erikssen J. Exercise blood pressure predicts mortality from myocardial infarction. Hypertension 1996; 27(3 Part 1): 324-329. (Pubitemid 26082074)
7. Kannel WB, McGee D, Gordon T. A general cardiovascular risk profile: the Framingham Study. Am J Cardiol 1976; 38(1): 46-51.
8. Nashar K, Nguyen JP, Jesri A, Morrow JD, Egan BM. Angiotensin receptor blockade improves arterial dis-tensibility and reduces exercise-induced pressor responses in obese hypertensive patients with the metabolic syndrome. Am J Hypertens 2004; 17(6): 477-482. (Pubitemid 38726160)
9. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006; 27(21): 2588-2605. (Pubitemid 44627304)
10. Naka KK, Tweddel AC, Parthimos D, Henderson A, Goodfellow J, Frenneaux MP. Arterial distensibility: acute changes following dynamic exercise in normal subjects. Am J Physiol Heart Circ Physiol 2003; 284(3): H970-H978. (Pubitemid 36228246)
11. Kingwell BA, Berry KL, Cameron JD, Jennings GL, Dart AM. Arterial compliance increases after moderate-intensity cycling. Am J Physiol 1997; 273(5 Part 2): H2186-H2191.
12. Sugawara J, Otsuki T, Tanabe T, Maeda S, Kuno S, Ajisaka R et al. The effects of low-intensity single-leg exercise on regional arterial stiffness. Jpn J Physiol 2003; 53(3): 239-241. (Pubitemid 37229299)
13. Kinlay S, Creager MA, Fukumoto M, Hikita H, Fang JC, Selwyn AP et al. Endothelium-derived nitric oxide regulates arterial elasticity in human arteries in vivo. Hypertension 2001; 38(5): 1049-1053. (Pubitemid 34252804)
14. Chang HJ, Chung J, Choi SY, Yoon MH, Hwang GS, Shin JH et al. Endothelial dysfunction in patients with exaggerated blood pressure response during treadmill test. Clin Cardiol 2004; 27(7): 421-425. (Pubitemid 38849969)
15. Stewart KJ, Sung J, Silber HA, Fleg JL, Kelemen MD, Turner KL et al. Exaggerated exercise blood pressure is related to impaired endothelial vasodilator function. Am J Hypertens 2004; 17(4): 314-320. (Pubitemid 38446845)
16. Tzemos N, Lim PO, Farquharson CAJ, Struthers, MacDonald TM. Dundee step test predicts vascular endothelial dysfunction in subjects with mild to moderate essential hypertension. Circulation 2004; 102(Supp II): 606.
17. Wilson MF, Sung BH, Pincomb GA, Lovallo WR. Exaggerated pressure response to exercise in men at risk for systemic hypertension. Am J Cardiol 1990; 66(7): 731-736. (Pubitemid 20285117)
18. Kelly RP, Tunin R, Kass DA. Effect of reduced aortic compliance on cardiac efficiency and contractile function of in situ canine left ventricle. Circ Res 1992; 71(3): 490-502.
19. Little WC, Cheng CP. Effect of exercise on left ventricular-arterial coupling assessed in the pressure-volume plane. Am J Physiol 1993; 264(5 Part 2): H1629-H1633. (Pubitemid 23154154)
20. Casadei B. The emerging role of neuronal nitric oxide synthase in the regulation of myocardial function. Exp Physiol 2006; 91(6): 943-955. (Pubitemid 44690806)
21. Paulus WJ, Shah AM. NO and cardiac diastolic function. Cardiovasc Res 1999; 43(3): 595-606.
22. Sagach VF, Shimanskaya TV, Sagach VV, Bogomolets AA. Coronary endothelium dysfunction and heart failure. J Heart Fail 1998; 5: 79.
23. Fortin J, Habenbacher W, Heller A, Hacker A, Grullen-berger R, Innerhofer J et al. Non-invasive beat-to-beat cardiac output monitoring by an improved method of transthoracic bioimpedance measurement. Comput Biol Med 2006; 36(11): 1185-1203. (Pubitemid 44286781)
24. McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR. Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol 2005; 46(9): 1753-1760. (Pubitemid 41531635)
25. Lehmann ED, Gosling RG, Parker JR, deSilva T, Taylor MG. A blood pressure independent index of aortic distensibility. Br J Radiol 1993; 66(782): 126-131. (Pubitemid 23069629)
26. Safar ME, London GM. Therapeutic studies and arterial stiffness in hypertension: recommendations of the European Society of Hypertension. The Clinical Committee of Arterial Structure and Function. Working Group on Vascular Structure and Function of the European Society of Hypertension. J Hypertens 2000; 18(11): 1527-1535.
27. Chen CH, Nevo E, Fetics B, Pak PH, Yin FC, Maughan WL et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tono-metry pressure. Validation of generalized transfer function. Circulation 1997; 95(7): 1827-1836. (Pubitemid 27164400)
28. Sharman JE, Lim R, Qasem AM, Coombes JS, Burgess MI, Franco J et al. Validation of a generalized transfer function to noninvasively derive central blood pressure during exercise. Hypertension 2006; 47(6): 1203-1208. (Pubitemid 44289180)
29. Chemla D, Hebert JL, Coirault C, Zamani K, Suard I, Colin P et al. Total arterial compliance estimated by stroke volume-to-aortic pulse pressure ratio in humans. Am J Physiol 1998; 274(2 Part 2): H500-H505.
30. Kelly RP, Ting CT, Yang TM, Liu CP, Maughan WL, Chang MS et al. Effective arterial elastance as index of arterial vascular load in humans. Circulation 1992; 86(2): 513-521.
31. Sharman JE, McEniery CM, Campbell R, Pusalkar P, Wilkinson IB, Coombes JS et al. Nitric oxide does not significantly contribute to changes in pulse pressure amplification during light aerobic exercise. Hypertension 2008; 51(4): 856-861. (Pubitemid 351654695)
32. Kleber FX, Vietzke G, Wernecke KD, Bauer U, Opitz C, Wensel R et al. Impairment of ventilatory efficiency in heart failure: prognostic impact. Circulation 2000; 101(24): 2803-2809. (Pubitemid 30396010)
33. Beaver WL, Wasserman K, Whipp BJ. A new method for detecting anaerobic threshold by gas exchange. J Appl Physiol 1986; 60(6): 2020-2027. (Pubitemid 16066969)
34. Howley ET, Bassett Jr DR, Welch HG. Criteria for maximal oxygen uptake: review and commentary. Med Sci Sports Exerc 1995; 27(9): 1292-1301.
35. Chang HJ, Chung JH, Choi BJ, Choi TY, Choi SY, Yoon MH et al. Endothelial dysfunction and alteration of nitric oxide/cyclic GMP pathway in patients with exercise-induced hypertension. Yonsei Med J 2003; 44(6): 1014-1020. (Pubitemid 38081568)
36. Doshi SN, Naka KK, Payne N, Jones CJ, Ashton M, Lewis MJ et al. Flow-mediated dilatation following wrist and upper arm occlusion in humans: the contribution of nitric oxide. Clin Sci (Lond) 2001; 101(6): 629-635. (Pubitemid 33135344)
37. Bech JN, Nielsen CB, Pedersen EB. Effects of systemic NO synthesis inhibition on RPF, GFR, UNa, and vasoactive hormones in healthy humans. Am J Physiol 1996; 270(5 Part 2): F845-F851.
38. Liang YL, Gatzka CD, Du XJ, Cameron JD, Kingwell BA, Dart AM. Effects of heart rate on arterial compliance in men. Clin Exp Pharm Physiol 1999; 26(4): 342-346. (Pubitemid 29180696)
39. O'Dochartaigh C, Ong H, Lovell S, Donnelly R, Hanratty C, Riley M et al. Changes in pulmonary vascular function after acute methionine loading in normal men. Clin Sci (Lond) 2004; 106(4): 413-419. (Pubitemid 38553590)
40. Kruger M, Kotter S, Grutzner A, Lang P, Andresen C, Redfield MM et al. Protein kinase G modulates human myocardial passive stiffness by phosphorylation of the titin springs. Circ Res 2009; 104(1): 87-94.
41. Harrison RW, Thakkar RN, Senzaki H, Ekelund UE, Cho E, Kass DA et al. Relative contribution of preload and afterload to the reduction in cardiac output caused by nitric oxide synthase inhibition with L-N(G)-methylarginine hydrochloride. Crit Care Med 2000; 28(5): 1263-1268. (Pubitemid 30324491)
42. Prendergast BD, Sagach VF, Shah AM. Basal release of nitric oxide augments the Frank-Starling response in the isolated heart. Circulation 1997; 96(4): 1320-1329. (Pubitemid 27344239)
43. Imai K, Sato H, Hori M, Kusuoka H, Ozaki H, Yokoyama H et al. Vagally mediated heart rate recovery after exercise is accelerated in athletes but blunted in patients with chronic heart failure. J Am Coll Cardiol 1994; 24(6): 1529-1535. (Pubitemid 24344250)
44. Cole CR, Blackstone EH, Pashkow FJ, Snader CE, Lauer MS. Heart-rate recovery immediately after exercise as a predictor of mortality. N Engl J Med 1999; 341(18): 1351-1357. (Pubitemid 29503574)
45. Herring N, Paterson DJ. Neuromodulators of peripheral cardiac sympatho-vagal balance. Exp Physiol 2009; 94(1): 46-53.
46. Stamler JS, Loh E, Roddy MA, Currie KE, Creager MA. Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 1994; 89(5): 2035-2040. (Pubitemid 24142778)
47. Mayer BX, Mensik C, Krishnaswami S, Derendorf H, Eichler HG, Schmetterer L et al. Pharmacokinetic-pharmacodynamic profile of systemic nitric oxide-synthase inhibition with L-NMMA in humans. Br J Clin Pharmacol 1999; 47(5): 539-544. (Pubitemid 29199726)
48. Haynes WG, Noon JP, Walker BR, Webb DJ. L-NMMA increases blood pressure in man. Lancet 1993; 342(8876): 931-932. (Pubitemid 23291613)
49. Sugawara J, Maeda S, Otsuki T, Tanabe T, Ajisaka R, Matsuda M. Effects of nitric oxide synthase inhibitor on decrease in peripheral arterial stiffness with acute low-intensity aerobic exercise. Am J Physiol Heart Circ Physiol 2004; 287(6): H2666-H2669. (Pubitemid 39557138)
50. Brett SE, Cockcroft JR, Mant TG, Ritter JM, Chowienc-zyk PJ. Haemodynamic effects of inhibition of nitric oxide synthase and of L-arginine at rest and during exercise. J Hypertens 1998; 16(4): 429-435. (Pubitemid 28195852)
51. Dyke CK, Proctor DN, Dietz NM, Joyner MJ. Role of nitric oxide in exercise hyperaemia during prolonged rhythmic handgripping in humans. J Physiol 1995; 488(Part 1): 259-265.
52. Sander M, Chavoshan B, Victor RG. A large blood pressure-raising effect of nitric oxide synthase inhibition in humans. Hypertension 1999; 33(4): 937-942. (Pubitemid 29186388)
53. Casino PR, Kilcoyne CM, Quyyumi AA, Hoeg JM, Panza JA. The role of nitric oxide in endothelium-dependent vasodilation of hypercholesterolemic patients. Circulation 1993; 88(6): 2541-2547. (Pubitemid 23360178)
54. Fisher JP, Young CN, Fadel PJ. Central sympathetic overactivity: maladies and mechanisms. Auton Neurosci 2009; 148(1-2): 5-15.
55. Osanai T, Fujita N, Fujiwara N, Nakano T, Takahashi K, Guan W et al. Cross talk of shear-induced production of prostacyclin and nitric oxide in endothelial cells. Am J Physiol Heart Circ Physiol 2000; 278(1): H233-H238. (Pubitemid 30101875)