Experimental blunt chest trauma impairs fracture healing in rats

Journal of Orthopaedic Research

Volumn 29, Issue 5, 2011, Pages 734-739

  Recknagel, Stefan ^a   Bindl, Ronny ^a   Kurz, Julian ^a   Wehner, Tim ^a   Ehrnthaller, Christian ^a   Knöferl, Markus Werner ^a   Gebhard, Florian ^a   Huber Lang, Markus ^a   Claes, Lutz ^a   Ignatius, Anita ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

blunt chest trauma; fracture healing; IL 6; systemic inflammation

Indexed keywords

GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALLUS; CONTROLLED STUDY; EXTERNAL FIXATOR; FRACTURE FIXATION; FRACTURE HEALING; GROUND REACTION FORCE; MALE; MOLECULAR MECHANICS; MOTION; NONHUMAN; OSTEOTOMY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; THORAX BLUNT TRAUMA; WOUND HEALING IMPAIRMENT;

ANIMALS; BIOMECHANICS; EXTERNAL FIXATORS; FEMORAL FRACTURES; FRACTURE HEALING; INFLAMMATION; INTERLEUKIN-6; MALE; RATS; RATS, WISTAR; THORACIC INJURIES; WOUNDS, NONPENETRATING;

EID: 79952786246     PISSN: 07360266     EISSN: 1554527X     Source Type: Journal    
DOI: 10.1002/jor.21299     Document Type: Article

References (38)

1. Giannoudis PV, Harwood PJ, Loughenbury P, et al. 2008. Correlation between IL-6 levels and the systemic inflammatory response score: can an IL-6 cutoff predict a SIRS state ? J Trauma 65: 646-652.
2. Strecker W, Gebhard F, Rager J, et al. 2002. Interleukin-6 (IL-6)-An early marker of chest trauma. Eur J Trauma 28: 75-84. (Pubitemid 34453449)
3. Bardenheuer M, Obertacke U, Waydhas C, et al. 2000. Epidemiology of the severely injured patient. A prospective assessment of preclinical and clinical management. AG Polytrauma of DGU. Unfallchirurg 103: 355-363.
4. Gebhard F, Kelbel MW, Strecker W, et al. 1997. Chest trauma and its impact on the release of vasoactive mediators. Shock 7: 313-317. (Pubitemid 127654286)
5. Flierl MA, Perl M, Rittirsch D, et al. 2008. The role of C5a in the innate immune response after experimental blunt chest trauma. Shock 29: 25-31.
6. Knoferl MW, Liener UC, Seitz DH, et al. 2003. Cardiopulmonary, histological, and inflammatory alterations after lung contusion in a novel mouse model of blunt chest trauma. Shock 19: 519-525.
7. Hensler T, Sauerland S, Bouillon B, et al. 2002. Association between injury pattern of patients with multiple injuries and circulating levels of soluble tumor necrosis factor receptors, interleukin-6 and interleukin-10, and polymorphonuclear neutrophil elastase. J Trauma 52: 962-970. (Pubitemid 34534485)
8. Knoferl MW, Liener UC, Perl M, et al. 2004. Blunt chest trauma induces delayed splenic immunosuppression. Shock 22: 51-56. (Pubitemid 40228210)
9. Perl M, Gebhard F, Braumuller S, et al. 2006. The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma. Crit Care Med 34: 1152-1159.
10. Seitz DH, Niesler U, Palmer A, et al. 2010. Blunt chest trauma induces mediator-dependent monocyte migration to the lung. Crit Care Med 38: 1852-1859.
11. Stensballe J, Christiansen M, Tonnesen E, et al. 2009. The early IL-6 and IL-10 response in trauma is correlated with injury severity and mortality. Acta Anaesthesiol Scand 53: 515-521.
12. Shorr RM, Crittenden M, Indeck M, et al. 1987. Blunt thoracic trauma. Analysis of 515 patients. Ann Surg 206: 200-205. (Pubitemid 17104964)
13. Bhandari M, Tornetta P III, Sprague S, et al. 2003. Predictors of reoperation following operative management of fractures of the tibial shaft. J Orthop Trauma 17: 353-361. (Pubitemid 36701599)
14. Reikeras O, Shegarfi H, Wang JE, et al. 2005. Lipopolysaccharide impairs fracture healing: an experimental study in rats. Acta Orthop 76: 749-753.
15. Claes LE, Heigele CA, Neidlinger-Wilke C, et al. 1998. Effects of mechanical factors on the fracture healing process. Clin Orthop Relat Res 355 Suppl: S132-S147.
16. Claes LE, Heigele CA., 1999. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech 32: 255-266. (Pubitemid 29125449)
17. Epari DR, Schell H, Bail HJ, et al. 2006. Instability prolongs the chondral phase during bone healing in sheep. Bone 38: 864-870. (Pubitemid 44500650)
18. Lienau J, Schell H, Duda GN, et al. 2005. Initial vascularization and tissue differentiation are influenced by fixation stability. J Orthop Res 23: 639-645. (Pubitemid 40631337)
19. Hankemeier S, Grassel S, Plenz G, et al. 2001. Alteration of fracture stability influences chondrogenesis, osteogenesis and immigration of macrophages. J Orthop Res 19: 531-538. (Pubitemid 32700963)
20. Claes L, Blakytny R, Gockelmann M, et al. 2009. Early dynamization by reduced fixation stiffness does not improve fracture healing in a rat femoral osteotomy model. J Orthop Res 27: 22-27.
21. Willie B, Adkins K, Zheng X, et al. 2009. Mechanical characterization of external fixator stiffness for a rat femoral fracture model. J Orthop Res 27: 687-693.
22. Wehner T, Wolfram U, Henzler T, et al. 2010. Internal forces and moments in the femur of the rat during gait. J Biomech 43: 2473-2479.
23. Morgan EF, Mason ZD, Chien KB, et al. 2009. Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function. Bone 44: 335-344.
24. Russell DM., 1997. Error measures for comparing transient data: part I: development of a comprehensive error measure. Proceedings of the 68th Shock and Vibration Symposium: p 175-184.
25. Connolly CK, Li G, Bunn JR, et al. 2003. A reliable externally fixated murine femoral fracture model that accounts for variation in movement between animals. J Orthop Res 21: 843-849. (Pubitemid 37045562)
26. Gebhard F, Pfetsch H, Steinbach G, et al. 2000. Is interleukin 6 an early marker of injury severity following major trauma in humans ? Arch Surg 135: 291-295. (Pubitemid 30154569)
27. Einhorn TA., 2005. The science of fracture healing. J Orthop Trauma 19: S4-S6. (Pubitemid 44620787)
28. Kon T, Cho TJ, Aizawa T, et al. 2001. Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing. J Bone Miner Res 16: 1004-1014. (Pubitemid 32467144)
29. Einhorn TA, Majeska RJ, Rush EB, et al. 1995. The expression of cytokine activity by fracture callus. J Bone Miner Res 10: 1272-1281.
30. Boyle WJ, Simonet WS, Lacey DL., 2003. Osteoclast differentiation and activation. Nature 423: 337-342. (Pubitemid 40852708)
31. Grundnes O, Reikeraas O., 2000. Effects of macrophage activation on bone healing. J Orthop Sci 5: 243-247. (Pubitemid 30431800)
32. De Benedetti F, Rucci N, Del Fattore A, et al. 2006. Impaired skeletal development in interleukin-6-transgenic mice: a model for the impact of chronic inflammation on the growing skeletal system. Arthritis Rheum 54: 3551-3563. (Pubitemid 44737167)
33. Schell H, Lienau J, Epari DR, et al. 2006. Osteoclastic activity begins early and increases over the course of bone healing. Bone 38: 547-554.
34. Ganter MT, Brohi K, Cohen MJ, et al. 2007. Role of the alternative pathway in the early complement activation following major trauma. Shock 28: 29-34. (Pubitemid 46956459)
35. Flierl MA, Schreiber H, Huber-Lang MS., 2006. The role of complement, C5a and its receptors in sepsis and multiorgan dysfunction syndrome. J Invest Surg 19: 255-265. (Pubitemid 44103001)
36. Ignatius A, Ehrnthaller C, Brenner RE, et al. 2010. The anaphylatoxin receptor C5aR is present during fracture healing in rats and mediates osteoblast migration in vitro. J Trauma (in press).
37. Claes L, Augat P, Suger G, et al. 1997. Influence of size and stability of the osteotomy gap on the success of fracture healing. J Orthop Res 15: 577-584. (Pubitemid 27433372)
38. Richardson JB, Cunningham JL, Goodship AE, et al. 1994. Measuring stiffness can define healing of tibial fractures. J Bone Joint Surg Br 76: 389-394. (Pubitemid 24148337)