Inhibition mechanism of rat α3β4 nicotinic acetylcholine receptor by the Alzheimer therapeutic tacrine

Biochemistry

Volumn 50, Issue 11, 2011, Pages 1763-1770

  Cheffer, Arquimedes ^a   Ulrich, Henning ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE ESTERASE; ALLOSTERIC SITE; ALZHEIMER; ALZHEIMER'S DISEASE; BINDING STUDIES; CELL CURRENT; CELL RECORDING; CHANNEL OPENING; COMPETITIVE INHIBITION; DOSE-RESPONSE CURVES; DRUG ADDICTION; FAST KINETICS; INHIBITION CONSTANTS; INHIBITION MECHANISMS; INHIBITOR CONCENTRATION; NICOTINIC ACETYLCHOLINE RECEPTORS; NICOTINIC ACETYLCHOLINE RECEPTORS (NACHRS); ON CURRENTS; OPEN CHANNELS; RECEPTOR ACTIVATION; RECEPTOR ACTIVITY; RELATED COMPOUNDS; SUBMICROMOLAR CONCENTRATIONS;

DRUG INTERACTIONS; EQUILIBRIUM CONSTANTS; TOBACCO;

BINDING SITES;

DIZOCILPINE; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA3BETA4; TACRINE; TENOCYCLIDINE; UNCLASSIFIED DRUG;

ALLOSTERISM; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; EQUILIBRIUM CONSTANT; KINETICS; NONHUMAN; PRIORITY JOURNAL; RAT; WHOLE CELL;

ALZHEIMER DISEASE; ANIMALS; CHOLINESTERASE INHIBITORS; DIZOCILPINE MALEATE; KINETICS; NICOTINIC ANTAGONISTS; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, NICOTINIC; TACRINE;

RATTUS;

EID: 79952777760     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi101789y     Document Type: Article

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