Expression and function of the natural cytotoxicity receptor NKp46 on circulating malignant CD4 T lymphocytes of sézary syndrome patients

Journal of Investigative Dermatology

Volumn 131, Issue 4, 2011, Pages 969-976

  Bensussan, Armand ^a,b   Remtoula, Natacha ^a   Sivori, Simona ^d   Bagot, Martine ^a,c   Moretta, Alessandro ^d   Marie Cardine, Anne ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c SAINT LOUIS HOSPITAL   (France)

^d UNIVERSITY OF GENOA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL2; NATURAL CYTOTOXICITY TRIGGERING RECEPTOR 1; T LYMPHOCYTE RECEPTOR;

ARTICLE; CANCER CELL; CANCER PATIENT; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL PROLIFERATION; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SEZARY SYNDROME; SIGNAL TRANSDUCTION;

EID: 79952773824     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2010.404     Document Type: Article

References (30)

1. Arnon TI, Achdout H, Levi O et al. (2005) Inhibition of the NKp30 activating receptor by pp65 of human cytomegalovirus. Nat Immunol 6:515-23 (Pubitemid 41716765)
2. Bagot M, Moretta A, Sivori S et al. (2001) CD4(+) cutaneous T-cell lymphoma cells express the p140-killer cell immunoglobulin-like receptor. Blood 97:1388-91 (Pubitemid 32183763)
3. Baniyash M (2004) TCR zeta-chain downregulation: curtailing an excessive inflammatory immune response. Nat Rev Immunol 4:675-87 (Pubitemid 39223074)
4. Bernengo MG, Novelli M, Quaglino P et al. (2001) The relevance of the CD4+ CD26- subset in the identification of circulating Sezary cells. Br J Dermatol 144:125-35 (Pubitemid 32154603)
5. Bouaziz JD, Remtoula N, Bensussan A et al. (2009) Absolute CD3+ CD158k+ lymphocyte count is reliable and more sensitive than cytomorphology to evaluate blood tumour burden in Sezary syndrome. Br J Dermatol 162:123-8
6. Edelman J, Meyerson HJ (2000) Diminished CD3 expression is useful for detecting and enumerating Sezary cells. Am J Clin Pathol 114:467-77 (Pubitemid 33049683)
7. Fuchs A, Cella M, Kondo T et al. (2005) Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. Blood 106:2076-82 (Pubitemid 41291722)
8. Giustiniani J, Bensussan A, Marie-Cardine A (2009) Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation. J Immunol 182:63-71
9. Guma M, Angulo A, Vilches C et al. (2004) Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 104:3664-71 (Pubitemid 39564443)
10. Klemke CD, Brade J, Weckesser S et al. (2008) The diagnosis of Sezary syndrome on peripheral blood by flow cytometry requires the use of multiple markers. Br J Dermatol 159:871-80
11. Mao X, Orchard G, Lillington DM et al. (2003) Amplification and overexpression of JUNB is associated with primary cutaneous T-cell lymphomas. Blood 101:1513-9 (Pubitemid 36182528)
12. Marie-Cardine A, Huet D, Ortonne N et al. (2007) Killer cell Ig-like receptors CD158a and CD158b display a coactivatory function, involving the c-Jun NH2-terminal protein kinase signaling pathway, when expressed on malignant CD4+ T cells from a patient with Sezary syndrome. Blood 109:5064-5 (Pubitemid 46827809)
13. Meresse B, Chen Z, Ciszewski C et al. (2004) Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease. Immunity 21:357-66 (Pubitemid 39208337)
14. Meresse B, Curran SA, Ciszewski C et al. (2006) Reprogramming of CTLs into natural killer-like cells in celiac disease. J Exp Med203:1343-55 (Pubitemid 43736602)
15. Moretta A, Bottino C, Vitale M et al. (2001) Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol 19:197-223 (Pubitemid 32368034)
16. Nakajima T, Goek O, Zhang X et al. (2003) De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. Circ Res 93:106-13 (Pubitemid 36919697)
17. Ortonne N, Huet D, Gaudez C et al. (2006) Significance of circulating T-cell clones in Sezary syndrome. Blood 107:4030-8 (Pubitemid 43726811)
18. Pessino A, Sivori S, Bottino C et al. (1998) Molecular cloning of NKp46: a novel member of the immunoglobulin superfamily involved in triggering of natural cytotoxicity. J Exp Med 188:953-60 (Pubitemid 28433421)
19. Poszepczynska E, Bagot M, Echchakir H et al. (2000) Functional characterization of an IL-7-dependent CD4(+)CD8alphaalpha(+) Th3-type malignant cell line derived from a patient with a cutaneous T-cell lymphoma. Blood 96:1056-63 (Pubitemid 30616873)
20. Poszepczynska-Guigne E, Schiavon V, D'Incan M et al. (2004) CD158k/ KIR3DL2 is a new phenotypic marker of Sezary cells: relevance for the diagnosis and follow-up of Sezary syndrome. J Invest Dermatol 122:820-3 (Pubitemid 38471353)
21. Rappl G, Muche JM, Abken H et al. (2001) CD4(+)CD7(-) T cells compose the dominant T-cell clone in the peripheral blood of patients with Sezary syndrome. J Am Acad Dermatol 44:456-61 (Pubitemid 32199965)
22. Remtoula N, Bensussan A, Marie-Cardine A (2008) Cutting edge: selective expression of inhibitory or activating killer cell Ig-like receptors in circulating CD4+ T lymphocytes. J Immunol 180:2767-71
23. Saez-Borderias A, Guma M, Angulo A et al. (2006) Expression and function of NKG2D in CD4+ T cells specific for human cytomegalovirus. Eur J Immunol 36:3198-206 (Pubitemid 44932721)
24. Sivori S, Vitale M, Morelli L et al. (1997) p46, a novel natural killer cell-specific surface molecule that mediates cell activation. J Exp Med 186:1129-36 (Pubitemid 27441156)
25. Su MW, Dorocicz I, Dragowska WH et al. (2003) Aberrant expression of T-plastin in Sezary cells. Cancer Res 63:7122-7 (Pubitemid 37413449)
26. Tang Q, Grzywacz B, Wang H et al. (2008) Umbilical cord blood T cells express multiple natural cytotoxicity receptors after IL-15 stimulation, but only NKp30 is functional. J Immunol 181:4507-15
27. van Bergen J, Thompson A, van der Slik A et al. (2004) Phenotypic and functional characterization of CD4 T cells expressing killer Ig-like receptors. J Immunol 173:6719-26 (Pubitemid 39541057)
28. van Doorn R, Dijkman R, Vermeer MH et al. (2004) Aberrant expression of the tyrosine kinase receptor EphA4 and the transcription factor twist in Sezary syndrome identified by gene expression analysis. Cancer Res 64:5578-86 (Pubitemid 39095552)
29. Vermeer MH, van Doorn R, Dijkman R et al. (2008) Novel and highly recurrent chromosomal alterations in Sezary syndrome. Cancer Res 68:2689-98 (Pubitemid 351556266)
30. Willemze R, Jaffe ES, Burg G et al. (2005) WHO-EORTC classification for cutaneous lymphomas. Blood 105:3768-85 (Pubitemid 40656118)