Circulating tumour cells: Their utility in cancer management and predicting outcomes

Therapeutic Advances in Medical Oncology

Volumn 2, Issue 6, 2010, Pages 351-365

  Krebs, Matthew G ^a   Hou, Jian Mei ^a   Ward, Tim H ^a   Blackhall, Fiona H ^a   Dive, Caroline ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

biomarker; circulating tumour cells; circulating tumour microemboli; clinical trials; personalized medicine; pharmacodynamic biomarker; predictive biomarker; prognosis

Indexed keywords

CARBOPLATIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; GEFITINIB; MONOCLONAL ANTIBODY; PACLITAXEL; SOMATOMEDIN C RECEPTOR;

BREAST CANCER; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER PATIENT; COLORECTAL CANCER; CYTOMETRY; DISEASE MARKER; HUMAN; LUNG NON SMALL CELL CANCER; METASTASIS; MUTATION; NUCLEIC ACID ANALYSIS; PREDICTION; PRIORITY JOURNAL; PROGNOSIS; PROSTATE CANCER; PROTEIN MICROARRAY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; TREATMENT OUTCOME; TUMOR BIOPSY; TUMOR CELL;

EID: 79952770095     PISSN: 17588340     EISSN: None     Source Type: Journal    
DOI: 10.1177/1758834010378414     Document Type: Review

References (66)

1. Aktas, B., Tewes, M., Fehm, T., Hauch, S., Kimmig, R. and Kasimir-Bauer, S. ( 2009) Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 11: R46.
2. Allan, A.L. and Keeney, M. ( 2010) Circulating tumor cell analysis: technical and statistical considerations for application to the clinic. J Oncol 2010: 426218.
3. Allard, W.J., Matera, J., Miller, M.C., Repollet, M., Connelly, M.C., Rao, C. et al. (2004) Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with non-malignant diseases. Clin Cancer Res 10: 6897-6904.
4. Alunni-Fabbroni, M. and Sandri, M.T. (2010) Circulating tumour cells in clinical practice: methods of detection and possible characterization. Methods 50: 289-297.
5. Ashworth, T. ( 1869) A case of cancer in which cells similar to those in the tumors were seen in the blood after death. Aust Med J 14: 146-149.
6. Attard, G., Swennenhuis, J.F., Olmos, D., Reid, A.H., Vickers, E., A'Hern, R. et al. (2009) Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer. Cancer Res 69: 2912-2918.
7. Budd, G.T., Cristofanilli, M., Ellis, M.J., Stopeck, A., Borden, E., Miller, M.C. et al. (2006) Circulating tumor cells versus imaging-predicting overall survival in metastatic breast cancer. Clin Cancer Res 12: 6403-6409.
8. Christiansen, J.J. and Rajasekaran, A.K. ( 2006) Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 66: 8319-8326.
9. Cohen, S.J., Punt, C.J., Iannotti, N., Saidman, B.H., Sabbath, K.D., Gabrail, N.Y. et al. (2008) Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer. J Clin Oncol 26: 3213-3221.
10. Cohen, S.J., Punt, C.J., Iannotti, N., Saidman, B.H., Sabbath, K.D., Gabrail, N.Y. et al. (2009) Prognostic significance of circulating tumor cells in patients with metastatic colorectal cancer. Ann Oncol 20: 1223-1229.
11. Coman, D.R., de, L.R. and MCC, U.M. ( 1951) Studies on the mechanisms of metastasis; the distribution of tumors in various organs in relation to the distribution of arterial emboli. Cancer Res 11: 648-651.
12. Cristofanilli, M., Budd, G.T., Ellis, M.J., Stopeck, A., Matera, J., Miller, M.C. et al. (2004) Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N Engl J Med 351: 781-791.
13. Cristofanilli, M., Hayes, D.F., Budd, G.T., Ellis, M.J., Stopeck, A., Reuben, J.M. et al. (2005) Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol 23: 1420-1430.
14. Danila, D.C., Heller, G., Gignac, G.A., Gonzalez-Espinoza, R., Anand, A., Tanaka, E. et al. (2007) Circulating tumor cell number and prognosis in progressive castration-resistant prostate cancer. Clin Cancer Res 13: 7053-7058.
15. de Bono, J.S., Attard, G., Adjei, A., Pollak, M.N., Fong, P.C., Haluska, P. et al. (2007) Potential applications for circulating tumor cells expressing the insulin-like growth factor-I receptor. Clin Cancer Res 13: 3611-3616.
16. de Bono, J.S., Scher, H.I., Montgomery, R.B., Parker, C., Miller, M.C., Tissing, H. et al. (2008) Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res 14: 6302-6309.
17. de Giorgi, U., Valero, V., Rohren, E., Dawood, S., Ueno, N.T., Miller, M.C. et al. (2009) Circulating tumor cells and [18F]fluorodeoxyglucose positron emission tomography / computed tomography for outcome prediction in metastatic breast cancer. J Clin Oncol 27: 3303-3311.
18. Desar, I.M., van Herpen, C.M., van Laarhoven, H.W., Barentsz, J.O., Oyen, W.J., van der. and Graaf, W.T. ( 2009) Beyond RECIST: molecular and functional imaging techniques for evaluation of response to targeted therapy. Cancer Treat Rev 35: 309-321.
19. Ewing, J. ( 1928) Neoplastic Diseases, 6th edn, WB Saunders: Philadelphia, PA.
20. Fehm, T., Becker, S., Duerr-Stoerzer, S., Sotlar, K., Mueller, V., Wallwiener, D. et al. (2007) Determination of HER 2 status using both serum HER 2 levels and circulating tumor cells in patients with recurrent breast cancer whose primary tumor was HER 2 negative or of unknown HER 2 status. Breast Cancer Res 9: R74.
21. Fidler, I.J. ( 1970) Metastasis: quantitative analysis of distribution and fate of tumor embolilabeled with 125 I-5-iodo-2’-deoxyuridine. J Natl Cancer Inst 45: 773-782.
22. Fidler, I.J. ( 2003) The pathogenesis of cancer metastasis: the ‘seed and soil’ hypothesis revisited. Nat Rev Cancer 3: 453-458.
23. Fidler, I.J. and Poste, G. ( 2008) The “seed and soil” hypothesis revisited. Lancet Oncol 9: 808.
24. Friedl, P. and Gilmour, D. (2009) Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 10: 445-457.
25. Hayes, D.F., Cristofanilli, M., Budd, G.T., Ellis, M.J., Stopeck, A., Miller, M.C. et al. (2006) Circulating tumor cells at each follow-up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res 12: 4218-4224.
26. Hayes, D.F., Walker, T.M., Singh, B., Vitetta, E.S., Uhr, J.W., Gross, S. et al. (2002) Monitoring expression of HER-2 on circulating epithelial cells in patients with advanced breast cancer. Int J Oncol 21: 1111-1117.
27. Hou, J.M., Greystoke, A., Lancashire, L., Cummings, J., Ward, T., Board, R. et al. (2009) Evaluation of circulating tumor cells and serological cell death biomarkers in small cell lung cancer patients undergoing chemotherapy. Am J Pathol 175: 808-816.
28. Ilina, O. and Friedl, P. (2009) Mechanisms of collective cell migration at a glance. J Cell Sci 122: 3203-3208.
29. Kobayashi, S., Boggon, T.J., Dayaram, T., Janne, P.A., Kocher, O., Meyerson, M. et al. (2005) EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 352: 786-792.
30. Krebs, M.G., Sloane, R., Priest, L., Lancashire, L., Hou, J.M., Greystoke, A. et al. (2010) Evaluation and prognostic significance of circulating tumor cells in patients with non small cell lung cancer (NSCLC). J Clin Oncol, in press.
31. Leversha, M.A., Han, J., Asgari, Z., Danila, D.C., Lin, O., Gonzalez-Espinoza, R. et al. (2009) Fluorescence in situ hybridization analysis of circulating tumor cells in metastatic prostate cancer. Clin Cancer Res 15: 2091-2097.
32. Liotta, L.A., Saidel, M.G. and Kleinerman, J. ( 1976) The significance of hematogenous tumor cell clumps in the metastatic process. Cancer Res 36: 889-894.
33. Liu, M.C., Shields, P.G., Warren, R.D., Cohen, P., Wilkinson, M., Ottaviano, Y.L. et al. (2009) Circulating tumor cells: a useful predictor of treatment efficacy in metastatic breast cancer. J Clin Oncol 27: 5153-5159.
34. Maheswaran, S., Sequist, L.V., Nagrath, S., Ulkus, L., Brannigan, B., Collura, C.V. et al. (2008) Detection of mutations in EGFR in circulating lung-cancer cells. N Engl J Med 359: 366-377.
35. Mandrekar, S.J., Qi, Y., Hillman, S.L., Allen Ziegler, K.L., Reuter, N.F., Rowland Jr, K.M. et al. (2010) Endpoints in phase II trials for advanced non-small cell lung cancer. J Thorac Oncol 5: 3-9.
36. Martin, M., Garcia-Saenz, J.A., Maestro de las Casas, M.L., Vidaurreta, M., Puente, J., Veganzones, S. et al. (2009) Circulating tumor cells in metastatic breast cancer: timing of blood extraction for analysis. Anticancer Res 29: 4185-4187.
37. Meng, S., Tripathy, D., Shete, S., Ashfaq, R., Haley, B., Perkins, S. et al. (2004) HER-2 gene amplification can be acquired as breast cancer progresses. Proc Natl Acad Sci U S A 101: 9393-9398.
38. Miller, M.C., Doyle, G.V. and Terstappen, L.W. ( 2010) Significance of circulating tumor cells detected by the CellSearch system in patients with metastatic breast colorectal and prostate cancer. J Oncol 2010: 617421.
39. Mok, T.S., Wu, Y.L., Thongprasert, S., Yang, C.H., Chu, D.T., Saijo, N. et al. (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361: 947-957.
40. Moreno, J.G., O'Hara, S.M., Gross, S., Doyle, G., Fritsche, H., Gomella, L.G. et al. (2001) Changes in circulating carcinoma cells in patients with metastatic prostate cancer correlate with disease status. Urology 58: 386-392.
41. Nagrath, S., Sequist, L.V., Maheswaran, S., Bell, D.W., Irimia, D., Ulkus, L. et al. (2007) Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450: 1235-1239.
42. Nakamura, S., Yagata, H., Ohno, S., Yamaguchi, H., Iwata, H., Tsunoda, N. et al. (2009) Multi-center study evaluating circulating tumor cells as a surrogate for response to treatment and overall survival in metastatic breast cancer. Breast Cancer [Epub Aug 1 2009 ].
43. Nguyen, D.X., Bos, P.D. and Massague, J. (2009) Metastasis: from dissemination to organ-specific colonization. Nat Rev Cancer 9: 274-284.
44. Nole, F., Munzone, E., Zorzino, L., Minchella, I., Salvatici, M., Botteri, E. et al. (2008) Variation of circulating tumor cell levels during treatment of metastatic breast cancer: prognostic and therapeutic implications. Ann Oncol 19: 891-897.
45. Olmos, D., Arkenau, H.T., Ang, J.E., Ledaki, I., Attard, G., Carden, C.P. et al. (2009) Circulating tumour cell (CTC) counts as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience. Ann Oncol 20: 27-33.
46. Paget, S. ( 1889) The distribution of secondary growths in cancer of the breast. Lancet 1: 571-573.
47. Pantel, K., Alix-Panabieres, C. and Riethdorf, S. ( 2009) Cancer micrometastases. Nat Rev Clin Oncol 6: 339-351.
48. Paterlini-Brechot, P. and Benali, N.L. ( 2007) Circulating tumor cells (CTC) detection: clinical impact and future directions. Cancer Lett 253: 180-204.
49. Pestrin, M., Bessi, S., Galardi, F., Truglia, M., Biggeri, A., Biagioni, C. et al. (2009) Correlation of HER 2 status between primary tumors and corresponding circulating tumor cells in advanced breast cancer patients. Breast Cancer Res Treat 118: 523-530.
50. Riethdorf, S., Fritsche, H., Muller, V., Rau, T., Schindlbeck, C., Rack, B. et al. (2007) Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system. Clin Cancer Res 13: 920-928.
51. Scher, H.I., Jia, X., de Bono, J.S., Fleisher, M., Pienta, K.J., Raghavan, D. et al. (2009) Circulating tumour cells as prognostic markers in progressive, castration-resistant prostate cancer: a reanalysis of IMMC 38 trial data. Lancet Oncol 10: 233-239.
52. Sequist, L.V., Bell, D.W., Lynch, T.J. and Haber, D.A. ( 2007) Molecular predictors of response to epidermal growth factor receptor antagonists in non-small-cell lung cancer. J Clin Oncol 25: 587-595.
53. Sequist, L.V., Nagrath, S., Toner, M., Haber, D.A. and Lynch, T.J. ( 2009) The CTC-chip: an exciting new tool to detect circulating tumor cells in lung cancer patients. J Thorac Oncol 4: 281-283.
54. Smirnov, D.A., Zweitzig, D.R., Foulk, B.W., Miller, M.C., Doyle, G.V., Pienta, K.J. et al. (2005) Global gene expression profiling of circulating tumor cells. Cancer Res 65: 4993-4997.
55. Stebbing, J. and Jiao, L.R. (2009) Circulating tumour cells as more than prognostic markers. Lancet Oncol 10: 1138-1139.
56. Swennenhuis, J.F., Tibbe, A.G., Levink, R., Sipkema, R.C. and Terstappen, L.W. (2009) Characterization of circulating tumor cells by fluorescence in situ hybridization. Cytometry A 75: 520-527.
57. Theodoropoulos, P.A., Polioudaki, H., Agelaki, S., Kallergi, G., Saridaki, Z., Mavroudis, D. et al. (2010) Circulating tumor cells with a putative stem cell
58. phenotype in peripheral blood of patients with breast cancer. Cancer Lett 288: 99-106.
59. Thiery, J.P. ( 2003) Epithelial-mesenchymal transitions in development and pathologies. Curr Opin Cell Biol 15: 740-746.
60. Thiery, J.P. and Sleeman, J.P. ( 2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7: 131-142.
61. Tibbe, A.G., Miller, M.C. and Terstappen, L.W. ( 2007) Statistical considerations for enumeration of circulating tumor cells. Cytometry A 71: 154-162.
62. Tol, J., Koopman, M., Miller, M.C., Tibbe, A., Cats, A., Creemers, G.J. et al. (2010) Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents. Ann Oncol 21: 1006-1012.
63. Tsuji, T., Ibaragi, S. and Hu, G.F. (2009) Epithelial-mesenchymal transition and cell cooperativity in metastasis. Cancer Res 69: 7135-7139.
64. Weiss, L. ( 2000) Metastasis of cancer: a conceptual history from antiquity to the 1990s. Cancer Metastasis Rev 19(1-11): 193-383.
65. Wittekind, C. and Neid, M. ( 2005) Cancer invasion and metastasis. Oncology 69(Suppl 1): 14-16.
66. Yang, J., Mani, S.A. and Weinberg, R.A. ( 2006) Exploring a new twist on tumor metastasis. Cancer Res 66: 4549-4552.